Zestoretic (lisinopril and hydrochlorothiazide) is a “combination” blood pressure drug that both relaxes blood vessels (ACE inhibitor) and reduces water in the body (diuretic) to reduce blood pressure. Zestoretic is prescribed to patients with high blood pressure who have not succeeded with a single type of drug. The pharmacy price of Zestoretic is $483.35 for 30, 20-12.5mg tablets, but with SingleCare's Zestoretic coupon, it costs $2.54 for 30, 20-12.5mg tablets of generic Zestoretic.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 05/05/2026
Zestoretic (lisinopril and hydrochlorothiazide) is a “combination” blood pressure drug that both relaxes blood vessels (ACE inhibitor) and reduces water in the body (diuretic) to reduce blood pressure. Zestoretic is prescribed to patients with high blood pressure who have not succeeded with a single type of drug. The pharmacy price of Zestoretic is $483.35 for 30, 20-12.5mg tablets, but with SingleCare's Zestoretic coupon, it costs $2.54 for 30, 20-12.5mg tablets of generic Zestoretic.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Lisinopril-Hydrochlorothiazide Retail Price | Lisinopril-Hydrochlorothiazide SingleCare Price |
|---|---|---|
| CVS Pharmacy | $17.70 | $17.40 |
| Walmart | $7.82 | $5.70 |
| Walgreens | $21.00 | $14.10 |
| Kroger Pharmacy | $16.80 | $3.21 |
| Albertsons Pharmacy | $16.89 | $5.34 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Zestoretic (lisinopril and hydrochlorothiazide) is a “combination” blood pressure drug that both relaxes blood vessels (ACE inhibitor) and reduces water in the body (diuretic) to reduce blood pressure. Zestoretic is prescribed to patients with high blood pressure who have not succeeded with a single type of drug. The pharmacy price of Zestoretic is $483.35 for 30, 20-12.5mg tablets, but with SingleCare's Zestoretic coupon, it costs $2.54 for 30, 20-12.5mg tablets of generic Zestoretic.
Without insurance, customers can expect to pay $483.35 for 30, 20-12.5mg tablets for Zestoretic, but this price may vary. With a SingleCare savings card, the cost of Zestoretic drops to $2.54 for 30, 20-12.5mg tablets of generic Zestoretic.
The amount of your Zestoretic copay depends on your insurance plan. With a SingleCare Zestoretic coupon, your prescription will cost $2.54 for 30, 20-12.5mg tablets of generic Zestoretic, which may be lower than your insurance copay. Consult with your pharmacist to determine what's best for you.
Zestoretic is often not covered by Medicare Part D and Medicare Advantage prescription drug plans. Lisinopril and hydrochlorothiazide generic combination drugs, however, usually are covered. For Medicare patients with a prescription for Zestoretic, a SingleCare Zestoretic coupon lowers the cost to $2.54 for 30, 20-12.5mg tablets of generic Zestoretic.
Zestoretic is a brand-name blood pressure medication. At the present time, several different pharmaceutical companies manufacture generic Zestoretic, including Med Pharma, Aurobindo, Hikma, Lupin, Mylan, and several others, as generic lisinopril and hydrochlorothiazide. Before you pay for your Zestoretic prescription, find free coupons for the generic or brand-name Zestoretic on our website or app.
Zestoretic (lisinopril and hydrochlorothiazide) is a combination blood pressure drug that relaxes the blood vessels and rids the body of extra water. Combined, these effects reduce blood pressure. Zestoretic is prescribed to patients with high blood pressure who have not succeeded with a single type of drug.
Lisinopril belongs to a class of blood pressure medications called ACE inhibitors, which lower blood pressure by blocking the action of a protein (angiotensin) that causes muscles in the blood vessels to contract and tighten the blood vessels. Lisinopril causes the blood vessels to lose tension, so they get wider, and blood pressure goes down.
Hydrochlorothiazide belongs to a class of drugs called diuretics (also called “water pills”) that increase the amount of salt and water in your urine. Lowering the amount of water in the bloodstream lowers the pressure within the blood vessels.
Zestoretic is taken as a tablet once daily.
While medicines may have side effects, many people experience no side effects, or the side effects they experience are very minimal. The most common physical side effects of Zestoretic include lightheadedness, dizziness, headache, fatigue, drowsiness, stomach upset, and blurred vision. Because Zestoretic contains a diuretic, Zestoretic may cause dehydration.
Zestoretic is toxic to fetuses, so it should not be taken by pregnant women.
Allergic reactions are rare and include swelling, rash, and shortness of breath.
This is not a complete list of side effects that may occur. Consult with your doctor or pharmacist about possible side effects before taking this medicine.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved