What is Ziprasidone Mesylate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Ziprasidone Mesylate overview

BRAND NAMES:

  • Geodon, PremierPro Rx Geodon

Generic Names:

  • Ziprasidone Mesylate

Uses:

  • Treats agitation in patients with schizophrenia.

Therapeutic Classes:

  • Antipsychotic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Ziprasidone Mesylate used for?

What form(s) does Ziprasidone Mesylate come in

  • Injectable

What are common Ziprasidone Mesylate doses?

  • Solution Reconstituted 20MG

Common Ziprasidone Mesylate prescriptions

  • Ziprasidone Mesylate
    20mg solution reconstituted

How to take Ziprasidone Mesylate

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Ziprasidone Mesylate

Ziprasidone Mesylate contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to ziprasidone.

Ziprasidone Mesylate warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, blood or bone marrow problems, diabetes, high cholesterol, trouble swallowing, or a history of seizures or breast cancer. Tell your doctor if you have heart rhythm problems (such as QT prolongation) or any heart or blood vessel problems, including low blood pressure, heart failure, or history of a heart attack.

  • This medicine may cause the following problems:Heart rhythm problemsNeuroleptic malignant syndrome (possibly life-threatening neurological disorder)Drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs such as the liver, kidney, or heartSerious skin reactionsTardive dyskinesia (trouble controlling muscle movements)

  • This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.

  • You may get overheated more easily while you are using this medicine. Use caution when you exercise strenuously or are outside in hot weather. Drink plenty of water to stay hydrated.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Fever, sweating, confusion, muscle stiffness, seizures

  • Increased thirst, hunger, or urination

  • Lightheadedness, dizziness, or fainting

  • Painful, prolonged erection of your penis

  • Twitching or muscle movements you cannot control (especially in your face, tongue, or jaw)

  • Unusual bleeding, bruising, or weakness

Ziprasidone Mesylate interactions

  • You should not receive this medicine together with amiodarone, arsenic trioxide, chlorpromazine, disopyramide, dofetilide, dolasetron mesylate, droperidol, gatifloxacin, halofantrine, levomethadyl acetate, mefloquine, mesoridazine, moxifloxacin, pentamidine, pimozide, probucol, procainamide, quinidine, sotalol, sparfloxacin, tacrolimus, or thioridazine.

  • Some medicines can affect how ziprasidone works. Tell your doctor if you are using any of the following:Carbamazepine, ketoconazole, levodopaBlood pressure medicineDiuretic (water pill)

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.

  • You may get overheated more easily while you are using this medicine. Use caution when you exercise strenuously or are outside in hot weather. Drink plenty of water to stay hydrated.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Ziprasidone Mesylate side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Chills, cough, sore throat, and body aches

  • Fast, slow, pounding, or uneven heartbeat

  • Twitching or muscle movements you cannot control (especially in your face, tongue, or jaw)

  • Increased thirst, hunger, or urination

  • Fever, skin rash, or swollen glands in your armpits, neck, or groin

  • Unusual bleeding, bruising, or weakness

  • Lightheadedness, dizziness, or fainting

  • Painful, prolonged erection of your penis

  • Fever, sweating, confusion, muscle stiffness, seizures

Less Serious Side Effects

  • Headache, nausea

  • Pain where the shot was given

  • Sleepiness, tiredness

  • Weight gain

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