What is Zolinza: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Zolinza overview

BRAND NAMES:

  • Zolinza

Generic Names:

  • Zolinza

Uses:

  • Treats cutaneous T-cell lymphoma (CTCL).

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Zolinza used for?

Zolinza is used to treat Cutaneous T-cell lymphoma. Cutaneous T-cell lymphoma is a type of non-Hodgkin lymphoma that affects the skin. Zolinza works by slowing or ceasing cancer cells growth. It is available to adults in the form of a capsule.

What form(s) does Zolinza come in

  • Capsule

What are common Zolinza doses?

  • Capsule 100MG

Common Zolinza prescriptions

  • Zolinza
    100mg capsule

How to take Zolinza

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine with food or milk.

  • Swallow the capsule whole. Do not open, crush, break, or chew it.

  • Drink at least 68 ounces (2 liters) of fluid every day to prevent dehydration.

  • Oral routeYou may also receive medicines to help prevent nausea and vomiting.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Drink at least 68 ounces (2 liters) of fluid every day to prevent dehydration.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine with food or milk.

  • Oral routeYou may also receive medicines to help prevent nausea and vomiting.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the capsule whole. Do not open, crush, break, or chew it.

What to do if you miss a dose of Zolinza

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeIf you vomit after taking your medicine, call your doctor or pharmacist for instructions.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Zolinza contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to vorinostat, or if you are pregnant.

Zolinza warnings

  • Oral routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose. Your doctor will give you a pregnancy test within 7 days before you use this medicine to make sure you are not pregnant.

  • Do not breastfeed during treatment with this medicine and for at least 1 week after the last dose.

  • Tell your doctor if you have liver disease, heart problems, diabetes, stomach or bowel problems (including nausea, vomiting, diarrhea), fluid or electrolyte imbalance, or a history of blood clots.

  • This medicine may cause the following problems:Increased risk of blood clots in the lungs or blood vesselsHigh blood sugar

  • Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).

  • Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Oral routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Zolinza interactions

  • Some medicines may affect how vorinostat works. Tell your doctor if you are using valproic acid or a blood thinner (including warfarin).

  • Make sure your doctor knows if you are breastfeeding or if you have kidney disease, liver disease, anemia, diabetes, stomach or bowel problems, a mineral imbalance (such as low potassium, calcium, or magnesium in your blood), or a history of blood clots.

  • This medicine may increase your risk for blood clots. Tell your doctor right away if you have chest pain, trouble breathing, or pain in your lower leg (calf) or if you cough up blood.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • This medicine may increase blood sugar levels. Tell your doctor if you have increased hunger or thirst, changes in how much you urinate, or unusual weight loss. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Cancer medicines can cause diarrhea, nausea, or vomiting. Make sure to drink enough liquids so you do not get dehydrated. Ask your doctor about ways to control these side effects.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Zolinza side effects

Serious Side Effects

  • Red or black stools, severe stomach pain, constipation, vomiting of blood or material that looks like coffee grounds

  • Tiny red dots on the skin, especially on the lower legs

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Changes in how much or how often you urinate, increased thirst or hunger, blurred vision, weight loss

  • Chest pain, trouble breathing, coughing up blood

  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches

  • Severe diarrhea, nausea, or vomiting, dizziness, lightheadedness, dry skin or mouth

  • Numbness or weakness in your arm or leg, or on one side of your body

  • Unusual bleeding, bruising, or tiredness

  • Sudden or severe headache, problems with vision, speech, or walking

  • Pain in your lower leg (calf)

Less Serious Side Effects

  • Loss of appetite

  • Mild diarrhea or nausea

  • Change or loss of taste

  • Thinning or loss of hair

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