What is Zorvolex? Uses, warnings & side effects

Updated May 14, 2025  •  Published Jun 17, 2021

Zorvolex overview

BRAND NAMES:

  • Zipsor, Cambia, Cataflam, Zorvolex, NuDiclo TabPAK, NuDroxiPAK DSDR-50, NuDroxiPAK DSDR-75, PrevidolRx Analgesic Pak, PrevidolRx Plus Analgesic Pak, Voltaren

Generic Names:

  • Diclofenac

Uses:

  • Treats pain. Also treats migraines. This medicine is an NSAID.

Therapeutic Classes:

  • Musculoskeletal Agent, Central Nervous System Agent, Antirheumatic, Antimigraine, Analgesic

Forms:

  • Long Acting Tablet, Coated Tablet, Tablet, Liquid, Capsule

How it’s taken:

  • By mouth

What is Zorvolex used for?

What form(s) does Zorvolex come in?

  • Long Acting Tablet

  • Coated Tablet

  • Tablet

  • Liquid

  • Capsule

What are common Zorvolex dosages?

  • Capsule 18MG

  • Capsule 35MG

Zorvolex images - What does Zorvolex look like?

  • Zorvolex
    18mg capsule

  • Zorvolex
    35mg capsule

How to take Zorvolex

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral solution: Mix the packet contents with 1 to 2 ounces (30 to 60 mL) of water. Do not use any liquid other than water for mixing the medicine. Mix well and drink it immediately on an empty stomach.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. .

What to do if you miss a dose of Zorvolex

Zorvolex contraindications - Who shouldn't take Zorvolex?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to diclofenac, aspirin, or another NSAID.

Zorvolex warnings

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.

  • Tell your doctor if you have kidney disease, liver disease, asthma, heart failure, high blood pressure, or heart or blood vessel problems, or a history of stomach ulcers or bleeding problems. Tell your doctor if you have phenylketonuria (PKU). Also tell your doctor if you drink alcohol.

  • This medicine may cause the following problems:Increased risk of heart attack, heart failure, or strokeBleeding in your stomach or intestinesLiver problemsSerious skin reactions

  • Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking

  • Rapid weight gain, swelling in your hands, ankles, or feet

Zorvolex interactions & what to avoid when taking Zorvolex

  • Do not use any other NSAID unless your doctor says it is okay. Some other NSAIDs are aspirin, diflunisal, ibuprofen, naproxen, or salsalate.

  • Some medicines and foods can affect how diclofenac works. Tell your doctor if you are also using any of the following:Cyclosporine, digoxin, lithium, methotrexate, pemetrexedBlood pressure medicineBlood thinner (such as warfarin)Diuretic (water pill)Medicine to treat depressionSteroid medicine

  • This medicine may cause the following problems:Increased risk of heart attack, heart failure, or strokeBleeding in your stomach or intestinesLiver problemsSerious skin reactions

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Zorvolex side effects - How does Zorvolex make you feel?

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, or red skin rash

  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Change in how much or how often you urinate

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking

Less Serious Side Effects

  • Constipation or diarrhea

  • Mild headache

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