Methotrexate is a prescription generic medication used to treat certain types of blood cancers, including leukemia and lymphoma. The intravenous form can also be used to treat some types of cancer of the breast, head, and neck. More commonly, it is used to treat the autoimmune diseases rheumatoid arthritis and severe psoriasis. The average retail price of Methotrexate is around $99.25 for 100, 2.5mg tablets. You can lower your cash price to $12.27 by using a SingleCare Methotrexate discount coupon at pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 02/03/2026
Methotrexate is a prescription generic medication used to treat certain types of blood cancers, including leukemia and lymphoma. The intravenous form can also be used to treat some types of cancer of the breast, head, and neck. More commonly, it is used to treat the autoimmune diseases rheumatoid arthritis and severe psoriasis. The average retail price of Methotrexate is around $99.25 for 100, 2.5mg tablets. You can lower your cash price to $12.27 by using a SingleCare Methotrexate discount coupon at pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Methotrexate Sodium Retail Price | Methotrexate Sodium SingleCare Price |
|---|---|---|
| CVS Pharmacy | $39.48 | $24.41 |
| Walmart | $47.28 | $16.83 |
| Walgreens | $41.12 | $27.52 |
| Kroger Pharmacy | $72.00 | $18.72 |
| Albertsons Pharmacy | $79.68 | $12.96 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Methotrexate is a prescription generic medication used to treat certain types of blood cancers, including leukemia and lymphoma. The intravenous form can also be used to treat some types of cancer of the breast, head, and neck. More commonly, it is used to treat the autoimmune diseases rheumatoid arthritis and severe psoriasis. The average retail price of Methotrexate is around $99.25 for 100, 2.5mg tablets. You can lower your cash price to $12.27 by using a SingleCare Methotrexate discount coupon at pharmacies.
The generic of Methotrexate costs $12.27 for 24, 2.5mg tablets with a free Methotrexate coupon from SingleCare. You could pay less depending on your Rx information. Use the dropdown menu above to enter your Rx details (i.e., brand/generic, form, dosage, quantity) to find the most accurate price of Methotrexate with SingleCare at your local pharmacies.
Methotrexate may cost around $99.25 or even more if you do not have insurance coverage. Using a SingleCare Methotrexate prescription discount card can help you to save on your prescription medication. Lower your cost to $12.27 when you use your savings card at neighborhood pharmacies such as Longs Drugs, Walmart, Kroger, Fry's, and Harris Teeter.
The average cost of Methotrexate with insurance tends to vary based on the type of health insurance plan you are enrolled in and the level of benefits you are entitled to. You may need to contact your insurance provider directly to get an accurate cost for your Methotrexate prescription. You can also save on Methotrexate by using SingleCare's Methotrexate coupons. Redeem instant savings and pay just $12.27 for Methotrexate when you use your SingleCare coupon.
Methotrexate is currently covered by all of the Medicare Part D and Medicare Advantage plans. Your average copay costs may range from free to $31 for this medication. You can also save on this medication by using a SingleCare savings card. Redeem instant savings at participating pharmacies and pay a reduced rate of $12.27 for your Methotrexate prescriptions when you use your SingleCare discount card.
Medicaid typically covers Methotrexate too. Coverage varies depending on a state’s plan, and an individual’s out-of-pocket expense for Methotrexate with Medicaid depends on their specific plan, deductible, and the coverage stage they are in. If Medicaid doesn’t cover Methotrexate or if the copay with Medicaid is still high, consider paying with a SingleCare coupon instead. Our coupons cannot be used with Medicaid, or Medicare, either for that matter, but the discounted price of Methotrexate could be less expensive than the price when using insurance.
Methotrexate is a generic prescription drug. The brand-name versions of this medication’s oral tablet form are Trexall, and oral solution forms are Jylamvo and Xatmep. Injectable versions go by the brand names Otrexup and Rasuvo.
SingleCare is one of the most convenient ways to get discounted pricing on your over-the-counter and prescription medications. Our customers usually save as much as 80% on their medications when they present their SingleCare savings at participating pharmacies such as CVS and Walgreens. You could pay just $12.27 for Methotrexate, instead of $99.25 for 100, 2.5mg tablets.
The HealthWell Foundation Copay Program is a patient assistance program that provides free or discounted medications to patients who meet specific eligibility requirements, including having certain health conditions, being insured, and having an income below a defined level. Contact this program directly to learn more about how you can join and the ways you can save on your Methotrexate prescription.
Methotrexate is a generic medication that is manufactured by Amneal Pharmaceuticals LLC, Mylan Pharmaceuticals Inc., as well as other generic manufacturers. Contacting these companies can help you learn more about various savings options that may be available, such as Methotrexate manufacturer coupon codes, rebates, and free samples. Unfortunately, these types of savings opportunities are less common with generic drugs because they generally offer lower prices than brand-name products.
Treatment of cancer is highly specific to the cancer type and individual, but treatment of rheumatoid arthritis and psoriasis is more standardized. The alternative antirheumatic drugs include generic meds like azathioprine, cyclosporine, hydroxychloroquine, and leflunomide. Based on their generic status, they could be available at a competitive price with Methotrexate. Biologics, on the other hand, like Humira, Enbrel, Simponi, and Xeljanz, are typically more expensive.
Common side effects reported when using Methotrexate include nausea, vomiting, diarrhea, low blood cell counts from bone marrow problems, liver problems, hair loss, mouth ulcers, and skin reactions. Signs of more serious side effects may include dark urine, easy bruising or bleeding, enlargement of glands and lymph nodes, skin discoloration, fever, and weakness.
Methotrexate decreases folate levels in the blood, and patients who take Methotrexate often must take a folic acid supplement.
Methotrexate should not be taken by pregnant women or women trying to have a baby, as it can affect the development of the baby. Methotrexate has been noted to decrease sperm production in male patients. Consult your healthcare professionals for medical help if you are thinking of starting a family.
Allergic reactions to Methotrexate are rare, but you should seek emergency medical attention immediately if you notice any symptoms of a severe allergic reaction, including severe dizziness, trouble breathing, or difficulty swallowing.
Other side effects not listed here may also occu,r as this is not a complete list. Consult your healthcare provider for medical advice on Methotrexate.
SingleCare is accepted at most major pharmacies and grocers, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. You can text, email, print, or save your free Methotrexate coupon to your mobile wallet and show your pharmacist at the counter.
Chad Shaffer, MD, earned his medical doctorate from Penn State University and completed a combined Internal Medicine and Pediatrics residency at the University of Pittsburgh Medical Center and Children’s Hospital of Pittsburgh. He is board certified by the American Board of Internal Medicine and the American Board of Pediatrics. He has provided full-service primary care to all ages for over 15 years, building a practice from start up to over 3,000 patients. His passion is educating patients on their health and treatment, so they can make well-informed decisions.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved