Methotrexate is a generic drug used to treat certain types of cancer and to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Popular brand-name versions of this drug include Rheumatrex and Trexall. On average, the retail price of Methotrexate is $99.06 for 24, 2.5mg tablets at most pharmacies. Take a SingleCare Methotrexate coupon and take your price down to $12.27 for 24, 2.5mg tablets. Though Medicare does offer coverage for Methotrexate our coupons may be a more affordable option.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/18/2025
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Methotrexate is a generic drug used to treat certain types of cancer and to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Popular brand-name versions of this drug include Rheumatrex and Trexall. On average, the retail price of Methotrexate is $99.06 for 24, 2.5mg tablets at most pharmacies. Take a SingleCare Methotrexate coupon and take your price down to $12.27 for 24, 2.5mg tablets. Though Medicare does offer coverage for Methotrexate our coupons may be a more affordable option.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Methotrexate Sodium Retail Price | Methotrexate Sodium SingleCare Price |
|---|---|---|
| CVS Pharmacy | $37.68 | $29.41 |
| Walmart | $33.84 | $16.80 |
| Walgreens | $27.60 | $26.16 |
| Kroger Pharmacy | $73.26 | $18.72 |
| Albertsons Pharmacy | $77.76 | $12.96 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Methotrexate is a generic drug used to treat certain types of cancer and to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Popular brand-name versions of this drug include Rheumatrex and Trexall. On average, the retail price of Methotrexate is $99.06 for 24, 2.5mg tablets at most pharmacies. Take a SingleCare Methotrexate coupon and take your price down to $12.27 for 24, 2.5mg tablets. Though Medicare does offer coverage for Methotrexate our coupons may be a more affordable option.
If you do not have health insurance coverage then your Methotrexate costs may be as high as $99.06 for 24, 2.5mg tablets. Save on this total by using a SingleCare Methotrexate discount card. Pay just $12.27 for 24, 2.5mg tablets for your Methotrexate refill when you use SingleCare's card at local pharmacies.
The average cash price of Methotrexate with insurance tends to vary based on the type of health insurance plan you are enrolled in and the level of benefits you are entitled to. You may need to contact your insurance provider directly to get an accurate cost for your Methotrexate prescription. You can also save money on Methotrexate by using SingleCare's Methotrexate coupons. Redeem instant savings and pay just $12.27 for 24, 2.5mg tablets for Methotrexate when you use our free coupons.
Currently, Medicare does offer coverage for Methotrexate. Depending on the type of plan you have, your copay can range between $0–$31. In some cases, SingleCare may be a more affordable option than Medicare, take your savings card down to any participating pharmacy to compare prices.
Popular brand-name versions of this drug include Rheumatrex and Trexall. Amneal Pharmaceuticals LLC, Mylan Pharmaceuticals Inc., Pfizer Inc. are some Methotrexate manufacturers.
Methotrexate is a prescription drug that is commonly used for acute lymphoblastic leukemia, acute lymphocytic leukemia, acute nonlymphocytic leukemia, and others. Methotrexate is a member of the antimetabolites drug class. This drug works by interfering with the growth of certain types of cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. Methotrexate is commonly used after other medications have been tried without successful treatment of symptoms.
This drug may be right for you to treat your psoriasis or rheumatoid arthritis if you have low blood cell counts, a bone marrow disorder, a weakened or compromised immune system, liver disease (especially if caused by alcoholism), or if you are pregnant or breastfeeding.
Fever, chills, tiredness, not feeling well, mouth sores, nausea, upset stomach, dizziness, or abnormal liver function tests are some side effects you may experience while using Methotrexate.
Methotrexate can cause serious or life-threatening side effects. Tell your doctor if you have diarrhea, mouth sores, cough, shortness of breath, upper stomach pain, dark urine, numbness or tingling, muscle weakness, confusion, seizure, or skin rash that spreads and causes blistering and peeling.
This is not a complete list of side effects and others may occur. Talk to your healthcare professional for medical advice about side effects. You can also report additional side effects to the FDA.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved