What is Zyloprim: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Zyloprim overview

BRAND NAMES:

  • Zyloprim

Generic Names:

  • Allopurinol

Uses:

  • Treats gout and kidney stones. Also lowers the amount of uric acid in the blood.

Therapeutic Classes:

  • Urinary Stone Agent, Antigout

Forms:

  • Capsule, Tablet

How it’s taken:

  • By mouth

What is Zyloprim used for?

What form(s) does Zyloprim come in

  • Capsule

  • Tablet

What are common Zyloprim doses?

  • Tablet 100MG

  • Tablet 300MG

Common Zyloprim prescriptions

  • Zyloprim
    100mg tablet

  • Zyloprim
    300mg tablet

How to take Zyloprim

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink about 10 to 12 full glasses of water each day, unless otherwise directed by your doctor.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • You should also increase your fiber intake.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • You may have more gout attacks when you start using this medicine. Keep using the medicine even if this happens. Your doctor may give you other medicines (including colchicine, NSAIDs) to prevent gout attacks. The attacks should become shorter and less severe after you take allopurinol for several months.

  • You may take allopurinol after meals to prevent stomach upset.

  • You should also increase your fiber intake.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink about 10 to 12 full glasses of water each day, unless otherwise directed by your doctor.

  • You may take allopurinol after meals to prevent stomach upset.

  • You may have more gout attacks when you start using this medicine. Keep using the medicine even if this happens. Your doctor may give you other medicines (including colchicine, NSAIDs) to prevent gout attacks. The attacks should become shorter and less severe after you take allopurinol for several months.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Zyloprim

Zyloprim contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to allopurinol.

Zyloprim warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may make you drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • This medicine may cause the following:Liver problemsKidney problems

  • This medicine may cause serious skin reactions. Check with your doctor right away at the first sign of a skin rash or allergic reaction.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, high blood pressure, heart failure, seizures, or cancer (including multiple myeloma).

Zyloprim interactions

  • You may need to lessen your intake of animal protein, sodium, refined sugars, or foods rich in oxalate and calcium, especially if you have kidney stones that keep coming back.

  • Do not take large doses of vitamin C while you are using allopurinol.

  • Some foods and medicines can affect how allopurinol works. Tell your doctor if you are using any of the following: Amoxicillin, ampicillin, azathioprine, chlorpropamide, cyclosporine, dicumarol, mercaptopurine, sulfinpyrazoneBlood thinner (including dicumarol, warfarin)Diuretic (water pill)

Zyloprim side effects

Serious Side Effects

  • Pain when you urinate, cloudy or bloody urine, change in how much or how often you urinate

  • Pain when you urinate, blood in your urine

  • Dark urine or pale stools, loss of appetite, stomach pain, nausea, vomiting, yellow skin or eyes

  • Yellow skin or eyes

  • Blistering, peeling, red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Drowsiness

  • Diarrhea

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