Does Prozac cause weight gain?

Written by Karen BergerPharm.D.
Licensed Pharmacist
Updated Jan 12, 2026  •  Published Jan 12, 2026
Fact Checked

Yes, Prozac can cause weight gain, but it’s relatively uncommon. In fact, some people lose weight while taking Prozac. A small percentage of patients may experience weight gain, but it is often linked to increased appetite as depression symptoms improve, rather than the medication itself. In some cases, early side effects like fatigue may reduce activity temporarily, contributing to mild weight changes.

Interested in learning more about how Prozac may affect weight? Read our full analysis: Does Prozac cause weight gain?


Medical disclaimer: This content is for general informational purposes only and does not constitute medical advice. Always consult your psychiatrist or other healthcare provider before making changes to your medication regimen.

Written by Karen BergerPharm.D.
Licensed Pharmacist

After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.

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