Premarin is a brand-name prescription medication that contains conjugated estrogens. It is used to replace estrogen, the female sex hormone, and treat symptoms of menopause. There are currently no generic alternatives of Premarin available. The average cash Premarin price is about $283.46 for 30, 0.625mg tablets. You may be able to get a discounted price of $80.55 for 30, 0.625mg tablets when you use a free and reusable SingleCare Premarin coupon at participating pharmacies near you.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Premarin is a brand-name prescription medication that contains conjugated estrogens. It is used to replace estrogen, the female sex hormone, and treat symptoms of menopause. There are currently no generic alternatives of Premarin available. The average cash Premarin price is about $283.46 for 30, 0.625mg tablets. You may be able to get a discounted price of $80.55 for 30, 0.625mg tablets when you use a free and reusable SingleCare Premarin coupon at participating pharmacies near you.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Premarin Retail Price | Estrogens Conjugated Retail Price | Estrogens Conjugated SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $252.90 | $216.00 | $83.70 |
| Walmart | $254.70 | $161.70 | $161.70 |
| Walgreens | $311.10 | - | - |
| Kroger Pharmacy | $267.90 | $242.10 | $185.40 |
| Albertsons Pharmacy | - | $213.30 | $199.50 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Premarin is a brand-name prescription medication that contains conjugated estrogens. It is used to replace estrogen, the female sex hormone, and treat symptoms of menopause. There are currently no generic alternatives of Premarin available. The average cash Premarin price is about $283.46 for 30, 0.625mg tablets. You may be able to get a discounted price of $80.55 for 30, 0.625mg tablets when you use a free and reusable SingleCare Premarin coupon at participating pharmacies near you.
The average Premarin price without insurance is $283.46 for 30, 0.625mg tablets. Prices for cash-paying customers can vary depending on the dosage and quantity prescribed, as well as the pharmacy where the drug is purchased.
You may be able to reduce your out-of-pocket costs by using a SingleCare copay card. You could get a discount off the average cash price and pay only $80.55 for 30, 0.625mg tablets for Premarin at a participating pharmacy.
The copay or out-of-pocket costs of Premarin will vary depending on the insurance plan. Your insurance plan has a drug formulary, which is a list that determines your coverage for prescription medications. If you have coverage for Premarin under your insurance plan, the cost may only be partially covered. Contact your insurance company or pharmacist to determine your cost of Premarin with insurance.
You can also compare your cost of Premarin with insurance to the cost with SingleCare. A SingleCare Premarin coupon could save you more money than your health insurance plan.
Premarin may be covered by Medicare and insurance plans. However, you may still have some out-of-pocket costs depending on your plan. Check with your insurance plan’s provider or pharmacist to determine your cost of Premarin with Medicare. The price may also depend on the coverage stage you’re in and whether you’ve satisfied your plan’s deductible.
Premarin savings cards, coupons, and rebates, among other savings options, may be offered by the manufacturer. In addition, your healthcare provider may be able to provide free samples. Eligible patients can apply for patient assistance programs provided by the manufacturer or third-party organizations to access Premarin for free or at a discounted cost.
You can also use a SingleCare Premarin coupon card and potentially save more on your prescription. SingleCare users often find that they save more money using a SingleCare coupon instead of a manufacturer coupon.
Premarin (conjugated estrogens) is a brand-name drug. A generic version of Premarin has yet to be approved by the FDA and released in the United States. Although generic drugs are usually cheaper than brand-name drugs, you can still save money by using a SingleCare Premarin coupon.
Premarin is a prescription drug that contains conjugated estrogens. It is primarily used to treat symptoms of menopause, such as hot flashes and vaginal dryness. Premarin may also be used for the prevention of osteoporosis (bone loss) in women who have been through menopause; hormone replacement therapy in women with ovarian failure or other conditions that cause a lack of estrogen in the body; and the supportive treatment of certain types of prostate or breast cancer in men and women.
Premarin is available as an oral tablet in the following dosages: 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, and 1.25 mg. A vaginal Premarin cream is also available to directly relieve vaginal dryness, burning, or irritation. The cream delivers 0.625 mg of conjugated estrogens per gram. While it may have fewer side effects than the oral tablets, the cream is typically reserved for localized symptoms of menopause.
Oral Premarin tablets can be administered daily or on a cyclical basis (such as 25 days of daily use followed by five days off of the drug). The vaginal cream is usually prescribed to be taken on a cyclical basis or twice every week. Follow your doctor's medical advice and instructions for the appropriate dosage and use of this medication.
The most common side effects of Premarin include headache, breast pain, irregular menstrual bleeding, bloating, hair loss, vaginal yeast infections, upset stomach, nausea, vomiting, and weight changes. Premarin can also cause serious side effects, such as blood clots, heart attack, stroke, dementia, high blood pressure, gallbladder disease, and liver problems. Other serious side effects may include ovarian or uterine cancer, breast cancer, and severe allergic reactions.
Before taking Premarin, talk to your doctor about your current list of medications and supplements to prevent drug interactions. For example, taking estrogen with progestin (rather than taking estrogen alone) may increase the risk of heart disease, stroke, blood clots, dementia, and cancer in some women.
This is not a complete list of possible side effects of Premarin. Consult with a healthcare provider for other possible side effects, drug interactions, precautions, and warnings before using Premarin.
Premarin is typically used to replace the female sex hormone called estrogen in women with low levels of estrogen, which may be caused by menopause, ovarian failure, or certain cancers. Premarin helps relieve menopausal symptoms, such as hot flashes and vaginal dryness. It can also help prevent bone loss in postmenopausal women and alleviate pain from certain breast and prostate cancers in men and women.
Premarin and Prempro are not the same. Premarin contains conjugated estrogens, whereas Prempro contains a combination of conjugated estrogens and medroxyprogesterone. Premarin or Prempro may be prescribed to women experiencing symptoms of menopause or low estrogen levels. These drugs may also be used to prevent osteoporosis. However, Prempro is reserved for women who still have a uterus, as the progestin can help reduce the risk of uterine cancer from estrogens. Women without a uterus should not take Prempro.
Women typically experience symptom relief with Premarin cream within 12 weeks of starting treatment with twice-weekly dosing. However, the time it takes to experience maximum effectiveness with Premarin can vary depending on the individual. Some people may experience relief more quickly or slower than others.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved