How does metformin help you lose weight?
Metformin helps with weight loss by reducing calorie intake through appetite regulation and lowering insulin levels. This happens because metformin decreases glucose production and absorption while improving insulin response, which may reduce hunger, carbohydrate cravings, and constant feelings of hunger rather than increasing energy expenditure.
Key takeaways
Metformin treatment has been associated with average weight loss of 5.8 kg (12.8 pounds) after six months, with 47.4% of people losing at least 5% of body weight.
Long-term studies showed a mean weight loss of 2.7 kg (about 6 pounds) at one year, with benefits remaining durable over several years.
Metformin reduced the development of diabetes by 31% over 2.8 years, and weight loss accounted for 64% of its diabetes-prevention effect, along with significant reductions in waist circumference.
| How metformin supports weight loss: Mechanisms compared | |
|---|---|
| Mechanism | Effect on weight |
| Appetite regulation | Decreased calorie intake and hunger |
| Insulin regulation | Lower hyerinsulinemia linked to cravings and weight gain |
| Gastrointestinal effects | May indirectly reduce food intake |
| Lipid profile improvement | Lower triglycerides and cholesterol, supporting metabolic health |
Want a deeper look? Read the full analysis on metformin, weight loss, dosing, and safety in the complete article.
Prescription resources
Metformin is a prescription medication available as immediate-release tablets, extended-release tablets, and oral solution. It is not FDA-approved for weight loss but is commonly prescribed off-label for people with prediabetes, metabolic syndrome, or PCOS. Savings tool: Check metformin prices and compare pharmacy coupons with SingleCare.
Medical disclaimer: This content is for general informational purposes only and does not constitute medical advice. Always consult your healthcare provider before making changes to your medication regimen.
Sources
Effectiveness of metformin on weight loss in non-diabetic individuals with obesity, Experimental and Clinical Endocrinology & Diabetes (2013)
Long-term safety, tolerability, and weight loss associated with metformin in the diabetes prevention program outcomes study, Diabetes Care (2012)
Metformin: Mechanisms in human obesity and weight loss, Current Obesity Reports (2020)
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