Nexium (esomeprazole magnesium) treats gastroesophageal reflux disease (GERD), esophagitis, and stomach ulcers by reducing stomach acid. Nexium is the brand-name version of esomeprazole magnesium. Nexium 24HR is also available over the counter (OTC) to treat frequent heartburn. Nexium capsules typically costs an average retail price of $1,059.56 for 90, 40mg capsules delayed release of Nexium. You can use SingleCare's Nexium coupons to pay $20.89 for 90, 40mg capsules delayed release of generic Nexium instead of full price for this prescription medication.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Nexium (esomeprazole magnesium) treats gastroesophageal reflux disease (GERD), esophagitis, and stomach ulcers by reducing stomach acid. Nexium is the brand-name version of esomeprazole magnesium. Nexium 24HR is also available over the counter (OTC) to treat frequent heartburn. Nexium capsules typically costs an average retail price of $1,059.56 for 90, 40mg capsules delayed release of Nexium. You can use SingleCare's Nexium coupons to pay $20.89 for 90, 40mg capsules delayed release of generic Nexium instead of full price for this prescription medication.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Nexium Retail Price | Esomeprazole Magnesium Retail Price | Esomeprazole Magnesium SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $960.30 | $667.27 | $99.00 |
| Walmart | - | $273.30 | $63.12 |
| Walgreens | $963.00 | $515.70 | $253.80 |
| Kroger Pharmacy | $1042.20 | $745.39 | $24.30 |
| Albertsons Pharmacy | - | $639.00 | $60.30 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Nexium (esomeprazole magnesium) treats gastroesophageal reflux disease (GERD), esophagitis, and stomach ulcers by reducing stomach acid. Nexium is the brand-name version of esomeprazole magnesium. Nexium 24HR is also available over the counter (OTC) to treat frequent heartburn. Nexium capsules typically costs an average retail price of $1,059.56 for 90, 40mg capsules delayed release of Nexium. You can use SingleCare's Nexium coupons to pay $20.89 for 90, 40mg capsules delayed release of generic Nexium instead of full price for this prescription medication.
The average retail price of Nexium without insurance is $1,059.56 for 90, 40mg capsules delayed release of Nexium. If you’re uninsured, you can lower the price by bringing our Nexium coupons to a participating pharmacy every time you refill your prescription.
SingleCare coupons are accepted at many local and national pharmacies. Use your SingleCare savings card and pay only $20.89 for 90, 40mg capsules delayed release of generic Nexium.
As with all prescription drugs, copays for Nexium will vary. Your insurance plan may or may not cover Nexium. If it does cover Nexium, it may not cover the full cost.
Compare your out-of-pocket expenses to your cost with a SingleCare discount. Even if you have insurance, you can use a SingleCare card. Our coupons for Nexium will bring your price down as low as $20.89 for 90, 40mg capsules delayed release of generic Nexium, which could be cheaper than the cost with insurance.
Check your Medicare plan to see if they cover Nexium. Fortunately, SingleCare has coupons for both brand-name and generic medications. Simply bring one of our printable coupons to a local pharmacy or show your pharmacist your SingleCare card or app to get a discounted price.
Contact the manufacturer to see if they have a patient assistance program. Luckily, you don't have to meet any strict eligibility criteria to use your free SingleCare discount card. Use our app or website to find the local pharmacy with the lowest price. Then, take your printable coupon, card, or mobile app with you to apply your discount at checkout. You could pay a reduced price of $20.89 for 90, 40mg capsules delayed release of generic Nexium. Check back for new coupons and savings before you refill Nexium.
Esomeprazole is the generic version of Nexium. Most insurance plans cover generic esomeprazole instead of brand-name Nexium. If your healthcare plan doesn't cover Nexium, ask your pharmacist if the generic is covered. If neither are covered, you can still save money by using your SingleCare card.
Nexium is a proton pump inhibitor (PPI). It provides heartburn relief by blocking an enzyme in the stomach that produces gastric acid. Stomach acid is normal, but too much of it can cause adverse effects including erosion of the stomach lining, acid reflux, heartburn, erosive esophagitis, and more. Prescription-strength Nexium is prescribed to treat stomach and esophageal conditions such as H. pylori infection and duodenal ulcer disease.
Nexium prescriptions are available in a 30-day supply of 20 mg or 40 mg delayed-release capsules. Nexium is also available in oral packets with strengths of 2.5 mg, 5 mg, 10 mg, 20 mg, or 40 mg. It's usually taken once a day at least one hour before a meal. Antacids may be taken with Nexium for quicker relief. If you're taking Nexium with sucralfate, then take Nexium at least 30 minutes before sucralfate. Always follow your healthcare provider's medical advice when using Nexium.
You may experience headaches or abdominal pain when you begin taking Nexium. Tell your doctor if these side effects don't go away. Other side effects include but are not limited to diarrhea, nausea, flatulence, constipation, and dry mouth. If you experience severe diarrhea, ask your doctor before using an anti-diarrheal medication. The use of Nexium may increase the risk of low magnesium levels, lupus, Clostridium difficile-associated diarrhea, and vitamin B-12 deficiency. Talk to your doctor or pharmacist for more information and a complete list of possible side effects and drug interactions.
Prescription-strength Nexium can be taken daily for up to eight weeks or longer depending on your condition. Over-the-counter Nexium 24HR is not recommended for everyday use on a long-term basis. Tell your doctor if you don't get heartburn relief after 14 days of self-treating with Nexium 24HR tablets. You should not need to use OTC Nexium more than once every four months.
Nexium can be purchased over the counter or with a prescription. If you're experiencing occasional heartburn, then you can try over-the-counter medications to relieve symptoms. Other OTC heartburn relief products similar to Nexium include Prevacid and Prilosec. For mild heartburn, you can also try an antacid like Tums or Alka-Seltzer.
To prevent serious side effects and possible drug interactions, ask a pharmacist for their recommendation based on your symptoms and current list of medications.
Dr. Anis Rehman is an American Board of Internal Medicine (ABIM) certified physician in Internal Medicine as well as Endocrinology, Diabetes, and Metabolism who practices in Illinois. He completed his residency at Cleveland Clinic Akron General and fellowship training at University of Cincinnati in Ohio. Dr. Rehman has several dozen research publications in reputable journals and conferences. He also enjoys traveling and landscape photography. Dr. Rehman frequently writes medical blogs for District Endocrine (districtendocrine.com) and hosts an endocrine YouTube channel, District Endocrine.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved