How does Prozac work?

Written by Gerardo SisonPharm.D.
Licensed Pharmacist
Updated Feb 4, 2026  •  Published Jan 12, 2026
Fact Checked

Prozac works by regulating serotonin levels in the brain. As a selective serotonin reuptake inhibitor (SSRI), it helps increase the availability of serotonin, which can improve mood, sleep, appetite, and energy levels. Prozac is effective for treating depression and other mental health conditions when taken appropriately.

Key takeaways

  • Prozac (fluoxetine) is an SSRI antidepressant approved to treat depression, OCD, bulimia nervosa, and panic disorder.

  • The FDA approved Prozac in 1987, and a generic version, fluoxetine, became available in August 2001.

  • By affecting serotonin, Prozac may improve mood, sleep, appetite, and energy, although individual responses can vary.

Comparison: Prozac vs. generic fluoxetine

Feature Prozac (brand) Fluoxetine (generic)
Active ingredient Fluoxetine Fluoxetine
Drug class SSRI SSRI
How it works Regulates serotonin Regulates serotonin
Effectiveness Equivalent Equivalent
Cost Higher Significantly lower
Dosage forms Capsules Capsules, tablets, liquid

Want a deeper look? Read our full analysis: Prozac generic availability, cost, and dosage

Prescription resources

  • Generic name: Fluoxetine

  • Brand name: Prozac

  • Drug class: Selective serotonin reuptake inhibitor (SSRI)

  • Common uses: Depression, OCD, bulimia nervosa, panic disorder

  • Savings tool: Check Prozac and fluoxetine prices at pharmacies near you with SingleCare


Medical disclaimer: This content is for general informational purposes only and does not constitute medical advice. Always consult your psychiatrist or other healthcare provider before making changes to your medication regimen.

Written by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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