How to take Viagra and Cialis together

Written by Gerardo SisonPharm.D.
Licensed Pharmacist
Updated Jan 13, 2026  •  Published Jan 13, 2026
Fact Checked

Viagra and Cialis should not be taken together. They work in similar ways as PDE5 inhibitors, and combining them can increase the risk of adverse side effects. This is primarily because using two drugs from the same class may intensify effects like low blood pressure and other serious reactions.

Key takeaways

  • Cialis (tadalafil) and Viagra (sildenafil) are both PDE5 inhibitors that increase blood flow to the penis.

  • Cialis can last up to 36 hours, while Viagra typically peaks within 30 minutes to two hours.

  • Combining PDE5 inhibitors increases the risk of hypotension, dizziness, and serious cardiovascular effects.

Comparing Cialis vs. Viagra

Feature Cialis (tadalafil) Viagra (sildenafil)
Drug class PDE5 inhibitor PDE5 inhibitor
Duration of effect Up to 36 hours Several hours
Typical dosing As needed or once daily As needed only
Can be taken together? No No
Key risk if combined Increased side effects Increased side effects

Warnings and safety context

Both medications lower blood pressure and share similar drug interactions. Using them together may raise the risk of dangerously low blood pressure, fainting, heart attack, or stroke, especially in people with underlying heart conditions.

Want a deeper look? Read our full analysis: Cialis vs. Viagra: Differences, safety, and costs

Prescription resources

  • Generic name: sildenafil (Viagra), tadalafil (Cialis)

  • Drug class: Phosphodiesterase-5 (PDE5) inhibitors

  • Savings tool: Check Viagra and Cialis prices at pharmacies near you with SingleCare

Medical disclaimer: This content is for general informational purposes only and does not constitute medical advice. Always consult your urologist or healthcare provider before making changes to your medication regimen.

Written by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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