5 ways to save on Creon

In this article:

• How much does Creon cost?
• 5 ways to save on Creon
• Is there a cheaper alternative to Creon?

In this article

• How much does Creon cost?
• 5 ways to save on Creon
• Is there a cheaper alternative to Creon?

People with exocrine pancreatic insufficiency (EPI) do not produce enough digestive enzymes from the pancreas to break down the sugars, fats, proteins, and starches from food they eat, which can throw a wrench into normal bodily functions. Creon is a brand-name medication that replaces the body’s pancreatic enzymes, helping restore normalcy to the digestive tract. Unfortunately, Creon can be pricey, but there are a few savings tips that can help reduce the out-of-pocket cost. 

How much does Creon cost?

The average retail price of Creon is about $1,701 for 100 delayed-release capsules. That’s around $17 per capsule without insurance and could cost more than $20,000 over an entire year. That price can vary depending on several factors. Most importantly, the dosage of Creon can significantly raise or lower the monthly cash price. Higher dosage strengths will be more expensive, and people could take more than 100 capsules monthly, depending on their diet and their individual pancreatic activity.

And while that might seem financially daunting, know that people don’t often have to pay the full cash price, especially people who have insurance. The drug’s manufacturer, AbbVie Inc., says that 90% of people with commercial insurance or Medicare Part D have preferred coverage with the lowest copay or coinsurance.

However, insurance coverage doesn’t necessarily mean Creon will be free. The Creon cost with Medicare Part D or commercial health insurance depends on the insurance plan, specifically, which drug tier it is placed in. Each plan has a formulary, which classifies drugs into tiers and explains how much their insurance plan will cover. Typically, generics occupy the lowest tier and receive the best coverage, while specialty drugs are on the highest tier and have the highest copays. As a brand-name drug, Creon may be on a middle or high tier.

How to save money on Creon

Insurance is the most common way people save money on Creon, but it’s not your only option. There are several reliable ways to get discounts on a Creon prescription without insurance, including some that might yield even better prices.

1. Free Creon coupons

A Creon coupon from SingleCare can knock Creon’s cash price down from $1,700 to $1,227 at Kroger for 100 delayed-release capsules, but discount prices vary by participating pharmacy, quantity, and dosage strength. Additional discounts on future refills or purchases can be earned by signing up for SingleCare’s bonus loyalty program.

2. Manufacturer savings programs

Creon’s manufacturer (AbbVie Inc.) has a savings program called CFCareForward that supplies the drug for as little as $0 to patients who have exocrine pancreatic insufficiency from cystic fibrosis. Not every patient is eligible, so check the eligibility criteria and enrollment instructions on the CFCareForward website.

AbbVie also has an overarching patient assistance program called myAbbVie Assist that provides free medications to patients who meet certain income requirements, and Creon is included. Eligible uninsured, commercially insured, and Medicare patients can receive Creon at no cost. Eligibility requirements and enrollment instructions can be found on the myAbbVie Assist website. 

The Creon savings card, called Creon Complete, can reduce the out-of-pocket cost of Creon for commercially insured patients with exocrine pancreatic insufficiency due to chronic pancreatitis, pancreatectomy, or other conditions (excluding cystic fibrosis). Enrollment and eligibility information can be found on the Creon website.

3. Medicare Extra Help

Medicare beneficiaries who meet specific income requirements might be eligible to enroll in Extra Help, which provides additional financial assistance for prescription medications. These funds can go toward copays, premiums, deductibles, coinsurance, and other costs. Visit the Medicare website for enrollment information and eligibility requirements.

4. Medicaid

Medicaid is a program funded by both the federal and state governments, which offers additional support to people with limited resources. The eligibility requirements are different for each state, so you’ll have to check your state government’s website to find out how to apply.

5. Comparing prices

Prescription drug prices vary significantly between pharmacies, even pharmacies in the same area. Check the SingleCare website or app for Creon prices in your area before you tell your healthcare provider where to send your prescription. 

Is there a cheaper alternative to Creon?

Creon isn’t the only drug on the market for pancreatic enzyme replacement therapy. There are several Creon alternatives that may be just as effective. Although there’s currently no generic version of Creon, other brand names of pancrelipase include Zenpep, Viokace, Pancreaze, and Pertzye. However, Creon is often more expensive than some of these alternatives, according to David Nazarian, MD, founder of My Concierge MD. For example, the average retail price of Pancreaze is around $172 for 100 capsules. 

“Creon, Pancreaze, and Zenpep all have similar side effects, including stomach discomfort, bloating and gas, diarrhea, nausea, and headaches,” Dr. Nazarian says.

Switching brands might seem like an easy decision when one is less expensive, but you should always let a healthcare professional make that call. They can develop the best treatment plan for you based on your diet, health conditions, medical history, and other medications and supplements you may be taking. 

The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of March 24, 2026. Prices vary by pharmacy. Visit our Creon coupon page for updated Creon prices near you.