Key takeaways
Fluconazole is a prescription antifungal used to treat various types of yeast infections.
Without insurance, fluconazole costs about $35 for two 150 mg tablets.
Ways to lower the cost include SingleCare discount cards, free samples, pharmacy price comparisons, and asking a healthcare provider about cheaper alternatives.
Fluconazole is a generic prescription antifungal medication FDA-approved to treat Candida yeast infections of the mouth, throat, vagina, and esophagus, as well as cryptococcal meningitis (a serious fungal infection of the fluids around the brain). Fluconazole is taken by mouth or injected. It is used for certain severe, invasive, or hard-to-treat fungal infections. The cost depends on how many doses are needed. Treatment may require just a few pills or injections, or it could last weeks or months. Fortunately, there are ways to save.
RELATED: How long does fluconazole take to work?
Is fluconazole covered by insurance?
Fluconazole treats many serious fungal infections. Most commercial health insurance, Medicare, and Medicaid plans cover a generic fluconazole prescription, though some insurance companies may not cover the brand-name version, Diflucan. Health insurance can reduce costs, but the actual out-of-pocket expense depends on the number of tablets prescribed, as well as the plan’s formulary, deductible, and copay.
How much does fluconazole cost without insurance?
The fluconazole 150 mg cost without insurance is about $35 for two tablets. One tablet is usually enough to treat an uncomplicated vaginal yeast infection, while other fungal infections may require several daily or weekly doses.
For uncomplicated yeast infections of the vagina, mouth, or throat, it may be possible to switch to a different azole antifungal. For vaginal infections, ask a healthcare professional about over-the-counter topical antifungals such as Vagisil or Monistat. OTC topical azoles may cost less than fluconazole, but they require several days of application, whereas fluconazole treatment requires just one tablet. They may not be suitable for severe or recurrent vaginal yeast infections. People who are pregnant must use topical antifungals in place of fluconazole, while those who are breastfeeding can use either topical azoles or fluconazole.
For oral thrush, a healthcare provider can prescribe clotrimazole lozenges or nystatin solution for mild infections. These alternatives may cost less and have fewer side effects.
Serious or systemic yeast infections are treated using well-established guidelines. Healthcare professionals prescribe the most effective antifungal for the specific infection, and fluconazole is often the preferred medication for many systemic cases.
Compare fluconazole prices to related drugs |
|||
|---|---|---|---|
| Drug name | Price without insurance | SingleCare price | Savings options |
| Generic fluconazole | $35 per 2, 150 mg tablets | $3 per 2, 150 mg tablets of generic fluconazole at Kroger | See latest prices |
| Diflucan
(brand-name fluconazole) |
$190 per 1, 35 mL of 40 mg/mL bottle | $29 per 1, 35 mL of 40 mg/mL bottle of brand-name Diflucan at Kroger | See latest prices |
| Lotrimin AF (clotrimazole) | $14 per 1, 133 gm of 2% bottle | $10 per 1, 30 gm of 1% cream of generic Lotrimin AF at Food Lion | See latest prices |
| Nystop (nystatin) | $178 per 1, 60 gm of 100,000 unit/gm bottle | $21 per 1, 60 gm of 100,000 unit/gm bottle of generic Nystop at Walmart | See latest prices |
| Monistat 3 (miconazole) | $25 per 3, 5 gm of 4% boxes | $16 per 3, 5 gm of 4% boxes of brand-name Monistat 3 at Food Lion | See latest prices |
| Sporanox (itraconazole) | $1,926 per 60, 100 mg capsules | $67 per 60, 100 mg capsules of generic Sporanox at Walgreens | See latest prices |
RELATED: Fluconazole alternatives: what can I take instead of fluconazole?
How to get fluconazole without insurance
Fluconazole without insurance costs $35 for two 150 mg pills. Some conditions, such as vaginal yeast infections, only require one pill. However, the cost can add up when treating infections that require days, weeks, or months of dosing. The best way to save is to find options that fit the treatment requirements. This may involve coupons, patient assistance programs, or comparing prices across pharmacies.
1. Save money immediately with a SingleCare discount card
A free SingleCare coupon can lower the price of fluconazole to about $2 per tablet at Kroger, saving up to 80% on fluconazole and thousands of other medications. Coupons are accepted at major pharmacy chains and require no sign-up.
Save up to 80% on Fluconazole with SingleCare Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
2. Ask the prescriber for a free sample
Some fluconazole prescriptions only require a one- or two-day supply. The prescribing healthcare provider may have free samples of brand-name Diflucan. Though Diflucan typically costs more than generic fluconazole, a free sample costs nothing.
3. Shop around for the lowest price
Pharmacies charge different prices for the same prescription medications. SingleCare’s fluconazole coupon page can help compare prices at pharmacies near you before you leave your house.
4. Look into community health clinics
Community health clinics may sell essential generic medicines, such as fluconazole, at very low prices. Look especially for 340 B clinics or hospitals, which may offer fluconazole at low cost based on income.
5. Try a different antifungal
Depending on the type and severity of the infection, fluconazole may be replaced with another azole antifungal or an over-the-counter option. Ask a healthcare provider about other antifungal treatments to save money.
Lea este artículo en español aquí.
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Jun. 3, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Fact sheet: the 340B drug pricing program, American Hospital Association (2025)
- Fluconazole tablet prescribing information, DailyMed (NIH National Library of Medicine) (2025)
- Oral candidiasis, StatPearls (2023)
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
- Evidence-based: Our content is sourced from reputable U.S.-based healthcare professionals and peer-reviewed research.
- Trustworthy: All of SingleCare’s content goes through a multi-phase review process by our writers, editors, and Medical Board in order to provide clear and credible information.