Breztri coupon card & savings guide

In this article:

• How much does Breztri cost?
• 5 ways to save on Breztri
• Is there a cheaper alternative to Breztri?

In this article

• How much does Breztri cost?
• 5 ways to save on Breztri
• Is there a cheaper alternative to Breztri?

Breztri Aerosphere is a three-in-one inhaler that contains budesonide, glycopyrrolate, and formoterol fumarate. Healthcare professionals prescribe it as a maintenance treatment in people with chronic obstructive pulmonary disease (emphysema or chronic bronchitis). As a brand-name drug, Breztri’s average cost isn’t what most people would call cheap, but there are ways to bring the price down. This article provides the essential details on a few of the most reliable money-saving methods. 

RELATED: COPD Coupons and Resources

How much does Breztri cost?

For someone paying completely out of pocket, Breztri costs an average of $933 for a 30-day supply. That’s around $31 per dose. The annual cost could exceed $11,000, which might not be doable for everyone.

Most people who have commercial insurance, a Medicare Part D plan, or a Medicare Advantage plan with drug benefits might not have to pay that much, since many of these plans cover Breztri. But it’s important to check with your insurance provider since “some plans may cover Breztri under a high-tier copay, while others might not cover it at all, leading to high out-of-pocket expenses,” according to Sazan Sylejmani, Pharm.D., a pharmacist in Westmont, Illinois.

According to the manufacturer, AstraZeneca, the average out-of-pocket cost for people with private or employer-provided health insurance coverage is $48.83 per month, and for people with Medicare drug coverage, it’s $44.70 per month. With Medicaid, the average out-of-pocket cost is only a few dollars.

Of course, you’ll need to examine your plan’s formulary for the details about how it covers Breztri. “In my work, I’ve seen patients struggle with the nuances of insurance coverage, where some are covered under their plan, and others face high out-of-pocket costs due to deductibles or formulary restrictions,” said Robert McLaughlin II, MD, an orthopedic surgeon at Boston Concierge Orthopedics. Some plans might also require prior authorization or trying other medications first. 

How to save money on Breztri

You have a few options when it comes to saving money on your Breztri Aerosphere prescription.

1. Get free Breztri Aerosphere coupons

SingleCare offers discounts on prescription drugs, including Breztri, at over 35,000 participating pharmacies nationwide. The average retail price of Breztri Aerosphere is $933 for a 30-day supply, but a SingleCare Breztri coupon card could bring that down to $572 at Kroger. Discounts vary at other participating pharmacies. Earn additional discounts by signing up for SingleCare’s bonus loyalty program. 

2. Check eligibility for Breztri patient assistance programs

For eligible commercially insured patients, the Breztri Zero Pay program may provide the medication at no cost. To qualify, you can’t be enrolled in any federal- or state-funded assistance programs, including Medicare, Medicaid, TriCare, and Veterans Affairs benefits. Eligibility also requires that the insurance company cover Breztri with no restrictions, such as prior authorization or step therapy. The insurance company must provide full coverage and cannot have policies that divert the copay card assistance away from your out-of-pocket expenses. There is a maximum annual savings limit.

AstraZeneca also has a patient assistance program called AZ&Me, which is for uninsured individuals and people who have Medicare but still need help paying for their prescription drugs. If you don’t have private insurance, meet other requirements, and have an annual adjusted gross income at or below 300% of the Federal Poverty Level (FPL), the company will provide Breztri for free. The savings program lasts for one year, and you can re-enroll after that.

3. Look into government or nonprofit assistance

The federal government, state governments, and certain nonprofit companies all offer prescription assistance for eligible individuals. For Medicare beneficiaries who meet the eligibility requirements, Medicare Extra Help can help cover Part D expenses. Each state also has its own pharmaceutical assistance programs, and the Patient Advocate Foundation’s Co-Pay Relief program can be a solid resource for people with private insurance plans. However, not everyone can meet the eligibility requirements. Ask your healthcare provider or talk to a program representative.

4. Shop around

It might seem strange to compare prices on medications, but since there’s not one regulatory price for Breztri, each pharmacy sets its own rates. Sometimes, the difference in prices between pharmacies amounts to thousands every year. In fact, a study from the U.S. Public Interest Research Groups found patients could save up to $5,400 per year by paying minimum drug prices instead of median prices. Calling around before you get your prescription filled could lead to significant savings.

5. Ask about alternatives and two-inhaler treatment

Because Breztri contains three different medications, it’s a pretty convenient treatment. But those medications (or ones like them) can come as two separate inhalers as well. “I’ve seen patients use similar combination inhalers with corticosteroids, long-acting muscarinic antagonists (LAMA), and long-acting beta agonists (LABA) that might offer a lower cost alternative depending on the generic availability and insurance coverage,” Dr. McLaughlin says.

For some people, using two inhalers might be cheaper, but it could be more expensive for others. Plus, it might make it harder to adhere to a consistent treatment plan since studies suggest that single-inhaler triple therapy has higher compliance than multiple inhalers. Either way, it might be worth asking for medical advice from your healthcare provider.

Is there a cheaper alternative to Breztri?

Not every COPD medication works optimally for every person. Breztri doesn’t have a generic version, and not every Breztri alternative will work for your specific case, but there are still plenty of other options for healthcare providers to consider:

• LABA/LAMA inhalers: Some combination inhalers, specifically Duaklir Pressair and Anoro Ellipta, combine a LABA with a LAMA. These may be more affordable. However, certain people might need a second inhaler with an inhaled corticosteroid (ICS).
• LABA/ICS inhalers: Combination inhalers like Advair Diskus/Advair HFA, Breo Ellipta, and Dulera combine a LABA and an inhaled corticosteroid. These are common alternatives and may cost a couple of hundred dollars less. To have all three inhaled drug classes like Breztri has, you would need to add a LAMA inhaler to the regimen.
• Corticosteroid inhalers: Pulmicort Flexhaler, fluticasone propionate HFA, and other purely corticosteroid inhalers might be cheaper than Breztri, but they might not be comprehensive enough to treat certain cases of COPD. A LABA/LAMA combination inhaler would also have to be used with one of these ICS inhalers to get the three drug types that are in Breztri.
• Beta-2 agonists: A long-acting bronchodilator like Perforomist (formoterol fumarate) might be more affordable, but certain cases of COPD might require a more comprehensive medication. Patients may also need an ICS inhaler and a LAMA inhaler to get all three medication categories, as Breztri has. 

Ultimately, it’s up to the healthcare provider to give medical advice on the best medication for each patient. With the passage of time and changing medical needs, your prescription needs can change, too. No matter which maintenance treatments they use, most COPD patients need a fast-acting rescue inhaler to use during a respiratory attack. 

RELATED: Breztri alternatives: what can I take instead of Breztri?

The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of March 25, 2026. Prices vary by pharmacy. Visit our Breztri coupon page for updated Breztri Aerosphere prices near you.