What is Afrezza: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Jan 25, 2023

Afrezza overview

BRAND NAMES:

  • Afrezza

Generic Names:

  • Afrezza

Uses:

  • Treats diabetes.

Therapeutic Classes:

  • Antidiabetic

Forms:

  • Powder Under Pressure

How it’s taken:

  • By breathing

What is Afrezza used for?

The average Afrezza price without insurance ranges from between about $304 and $326, depending on dosage, supply needed, and pharmacy location. To reduce the cost of this drug, print our free Afrezza discount coupon and save about up to 80% off when you fill your prescription at your local pharmacy.

What form(s) does Afrezza come in

  • Powder Under Pressure

What are common Afrezza doses?

  • Box 90 powder

  • Box 180 powder

Common Afrezza prescriptions

  • Afrezza
    180 powder box

  • Afrezza
    90 powder box

How to take Afrezza

  • Your healthcare provider will work with you to personalize your dose and treatment based on your insulin needs and lifestyle. You will be taught how to use the inhaler. Make sure you understand all instructions. Ask the doctor, nurse, or pharmacist if you have questions.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Use this medicine at the beginning of a meal.

  • To use:Remove a blister card from the foil package. Tear along the perforation to remove one strip. Remove the correct number of cartridges for your dose.Allow the cartridge to be at room temperature for 10 minutes before use.After you insert a cartridge, keep the inhaler level with the white mouthpiece on top and the purple base on the bottom. Do not shake or drop the inhaler, turn it upside down, or point the mouthpiece down after the cartridge has been inserted. If any of these occurs, throw away the cartridge and load a new one.After you use the inhaler, wipe it with a clean, dry cloth to clean it. Do not wash or rinse the inhaler.Throw away the inhaler after 15 days and use a new one.

  • Unopened foil packages: Store in the refrigerator. Do not freeze. If the foil package is not refrigerated, it must be used within 10 days.

  • Inhaler: Store in the refrigerator or at room temperature. Allow the inhaler to warm to room temperature for about 10 minutes before use.

  • Opened strips: Store at room temperature and use within 3 days.

  • Unopened blister cards and strips: If refrigerated, use within 1 month. If stored at room temperature, use within 10 days. Do not put a blister card or strip back into the refrigerator after it was stored at room temperature.

What to do if you miss a dose of Afrezza

Afrezza contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to human insulin or if you have a chronic lung problem, such as asthma or COPD.

Afrezza warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung disease, or a history of lung cancer. Tell your doctor if you smoke or have recently stopped smoking.

  • This medicine may cause the following problems:Low blood sugar or low potassium levels in the bloodDecrease in lung function or other lung problemsFluid retention or heart failure (when used with a thiazolidinedione [TZD] medicine)

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

Afrezza interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Do not drink alcohol while you are using this medicine.

  • Some medicines can change the amount of insulin you need to use and make it harder for you to control your diabetes. Tell your doctor about all other medicines that you are using.

Afrezza side effects

Serious Side Effects

  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat

  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

  • Cough, trouble breathing, chest tightness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Rapid weight gain, swelling in your hands, ankles, or feet

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