What is Agoneaze: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Agoneaze overview

BRAND NAMES:

  • 1st Relief Topical Spray, 7T Lido Gel, ACAT SUK Kit, Accucaine, Actisep, ACTIVE-PAC with Gabapentin, ACT Kit, Advanced DNA Medicated Collection Kit, Advanced DNA Medicated Collection Kit II, Advanced DNA Medicated Collection Kit III, Advocate Aftertest Topical Pain Relief Stick, AgonEaze, Alocane Emergency Burn, Alocane Emergency Burn Spray, Alocane Plus, LiProZonePak, HepMed IV Pack, ACAT SUK Kit, ACT Kit, AgonEaze, Anodyne LPT, Cadira Compliant Blood Stat, Ceftri-IM Injection, DermacinRx Cinlone-I CPI, DermacinRx Empricaine, IV Novice Pack, DermacinRx Prizopak, IV Infusion CPI, Lido BDK, Dolotranz

Generic Names:

  • Lidocaine-Prilocaine

Uses:

  • Treats pain in a certain body area. Also used to numb (decrease feeling in) an area before a procedure., Relieves pain. Also numbs the skin or genital area before certain medical procedures. This medicine is a topical anesthetic.

Therapeutic Classes:

  • Anesthetic, Amino Amide Combination, Anesthetic, Local, Anesthetic Combination, Antibacterial Combination, Antidote, Antihistamine Combination, Anti-Inflammatory, Antipruritic, Astringent, Corticosteroid Combination, Dental Agent, Dermatological Agent, Emollient, Hemorrhoidal, Anesthetic/Anti-Inflammatory Combination, Hemorrhoidal Anesthetic, Hemorrhoidal Anesthetic Combination, Analgesic Combination, Analgesic, Protectant, Dermatological, Wound Care Agent, Salicylate, Non-Aspirin Combination, Anesthetic, Local, Anesthetic Combination

Forms:

  • Dressing, Pad, Patch, Swab, Spray, Ointment, Gel/Jelly, Cream, Liquid, Soap, Lotion, Cream, Thin Sheet

How it’s taken:

  • On the skin, On the skin

What is Agoneaze used for?

Lidocaine-Prilocaine is prescribed to adults to numb an area of the body before an operation. This anesthetic is often applied to the penis and vagina before surgery to ensure that the patient doesn’t feel pain during the operation.

What form(s) does Agoneaze come in

  • Dressing

  • Pad

  • Patch

  • Swab

  • Spray

  • Ointment

  • Gel/Jelly

  • Cream

  • Liquid

  • Soap

  • Lotion

  • Cream

  • Thin Sheet

What are common Agoneaze doses?

  • Box 1 Kit

Common Agoneaze prescriptions

  • AgonEaze
    1 kit box

How to take Agoneaze

  • Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

  • A nurse or other trained health professional will give you this medicine. The medicine is usually applied right before the medical procedure in a hospital or clinic.

  • You may be taught how to apply this medicine to yourself or your child at home before the medical procedure.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Do not use it for any other condition without first checking with your doctor. This medicine may cause unwanted effects if too much is used, because more of it is absorbed through the skin.

  • Do not get this medicine near or into your eyes. If it does get into your eyes, rinse with water or saline solution right away.

  • Do not apply this medicine to open wounds, burns, broken, or inflamed skin, or to a large area of skin unless directed by your doctor.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Apply a thick layer of medicine to the area where numbness is needed. Do not spread the medicine on the skin.

  • Cover the medicine with a special bandage called an occlusive dressing. This will keep the medicine in place. Your doctor will give you the bandage or tell you what to use.

  • Seal the edges of the bandage to keep the medicine from leaking. Do not lift the bandage or disturb it. Keeping the medicine tightly covered helps it work properly.

  • For babies or young children, a second covering may be used to prevent them from touching the medicine.

  • Carefully watch your baby or child while the medicine is in place. Do not let them loosen or remove the bandage, touch the medicine, or put it in the mouth, eyes, nose, or ears.

  • Keep the bandage in place until you or your child arrive at the hospital or clinic.

  • Your doctor will remove the bandage and wipe the medicine off the skin before the medical procedure.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Keep the bandage in place until you or your child arrive at the hospital or clinic.

  • You may be taught how to apply this medicine to yourself or your child at home before the medical procedure.

  • Seal the edges of the bandage to keep the medicine from leaking. Do not lift the bandage or disturb it. Keeping the medicine tightly covered helps it work properly.

  • Do not apply this medicine to open wounds, burns, broken, or inflamed skin, or to a large area of skin unless directed by your doctor.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Your doctor will remove the bandage and wipe the medicine off the skin before the medical procedure.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Do not use it for any other condition without first checking with your doctor. This medicine may cause unwanted effects if too much is used, because more of it is absorbed through the skin.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

  • Apply a thick layer of medicine to the area where numbness is needed. Do not spread the medicine on the skin.

  • Do not get this medicine near or into your eyes. If it does get into your eyes, rinse with water or saline solution right away.

  • For babies or young children, a second covering may be used to prevent them from touching the medicine.

  • Cover the medicine with a special bandage called an occlusive dressing. This will keep the medicine in place. Your doctor will give you the bandage or tell you what to use.

  • Carefully watch your baby or child while the medicine is in place. Do not let them loosen or remove the bandage, touch the medicine, or put it in the mouth, eyes, nose, or ears.

  • A nurse or other trained health professional will give you this medicine. The medicine is usually applied right before the medical procedure in a hospital or clinic.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • The medicine may come with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

  • Do not get this medicine in your eyes, nose, or ears. If it does get on these areas, rinse it off right away. Some forms of this medicine should not be used on broken skin or inside the vagina or rectum. If you are not sure of the body areas where you can use this medicine, ask your pharmacist.

  • Topical application routeWash your hands with soap and water before and after you use this medicine. Follow your doctor's instructions about how to clean and care for your skin before and after you use this medicine.

  • For the cream, lotion, or ointment: Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently. You may need to shake the bottle of liquid, spray, or lotion before using it.

  • This medicine may come with a special applicator (a tool for applying the medicine), or with a special dressing to go over the medicine. Make sure you understand how to use the applicator or dressing. If you are not sure, ask your pharmacist.

  • The medicine may come with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

  • For the cream, lotion, or ointment: Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently. You may need to shake the bottle of liquid, spray, or lotion before using it.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Topical application routeWash your hands with soap and water before and after you use this medicine. Follow your doctor's instructions about how to clean and care for your skin before and after you use this medicine.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Do not get this medicine in your eyes, nose, or ears. If it does get on these areas, rinse it off right away. Some forms of this medicine should not be used on broken skin or inside the vagina or rectum. If you are not sure of the body areas where you can use this medicine, ask your pharmacist.

  • This medicine may come with a special applicator (a tool for applying the medicine), or with a special dressing to go over the medicine. Make sure you understand how to use the applicator or dressing. If you are not sure, ask your pharmacist.

What to do if you miss a dose of Agoneaze

  • If you are using this medicine on a regular schedule: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Agoneaze contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to lidocaine, prilocaine, or similar medicines.

  • Do not use this medicine if you have had an allergic reaction to any numbing medicine in the past, such as lidocaine or benzocaine. You should not take this medicine if you are allergic to any of its ingredients. Talk with your doctor or pharmacist about the ingredients in the medicine you are using.

Agoneaze warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, kidney disease, heart disease, heart rhythm problems, a blood disorder, G6PD, or lung or breathing problems.

  • This medicine may cause a rare, but serious blood problem called methemoglobinemia.

  • During the time that the skin feels numb, serious injury can occur. Be especially careful to avoid injury until the numbness wears off and you or your child have normal feeling in the area. Do not scratch or rub the area, and do not allow very hot or very cold objects to touch it.

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Do not use this medicine for more than 7 days unless your doctor or dentist tells you to.

  • Chest pain, or an uneven heartbeat.

  • Skin rash.

  • Swelling in the area where this medicine is applied.

  • Trembling (shaking).

  • If you are pregnant or breast feeding, talk to your doctor before using this medicine.

  • Some forms of this medicine should not be used in children under the age of 2 years old, unless a doctor says it is OK.

Agoneaze interactions

  • Topical anesthetic medicines have different ingredients, depending on the type and brand of medicine it is. The drugs or food you may need to avoid depends on the specific topical anesthetic medicine you are using. Make sure your doctor knows about all other medicines you are using.

  • Some forms of this medicine should not be used in children under the age of 2 years old, unless a doctor says it is OK.

  • Do not use this medicine for more than 7 days unless your doctor or dentist tells you to.

  • Some medicines can affect how lidocaine/prilocaine works. Tell your doctor if you are using any of the following:Acetaminophen, chloroquine, metoclopramide, mexiletine, primaquine, quinine, sulfasalazine, tocainideCancer medicine (including cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase)Medicine for heart rhythm problems (including amiodarone, bretylium, dofetilide, sotalol)Medicine to treat an infection (including dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamide)Medicine to treat seizures (including phenobarbital, phenytoin, sodium valproate)Nitrate or nitrite medicine (including nitric oxide, nitroglycerin, nitroprusside, nitrous oxide)

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

  • During the time that the skin feels numb, serious injury can occur. Be especially careful to avoid injury until the numbness wears off and you or your child have normal feeling in the area. Do not scratch or rub the area, and do not allow very hot or very cold objects to touch it.

  • Tell your doctor if you are also using a medicine to treat an abnormal heart rhythm such as amiodarone (Cordarone®), bretylium (Bretylol®), dofetilide (Tikosyn®), flecainide (Tambocor®), mexiletine (Mexitil®), propafenone (Rythmol®), quinidine (Cardioquin®, Quinaglute®, Quinidex®), sotalol (Betapace®), or tocainide (Tonocard®).

  • Using too much of this medicine or using it on a large area of your skin can cause serious unwanted effects. Remove the cream and contact your doctor right away if you or your child have any of these symptoms: lightheadedness, dizziness, vision problems, an irregular or slow heartbeat, difficulty with breathing, or convulsions.

  • This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hoarseness; trouble with breathing; trouble with swallowing; or any swelling of the hands, face, or mouth after you receive the medicine.

  • This medicine may cause a rare, but serious blood problem called methemoglobinemia. Remove the cream and call your doctor right away if you or your child develop a blue or bluish purple color on the lips, fingernails, or skin, or have headaches, dizziness, fainting, sleepiness, or trouble with breathing.

Agoneaze side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blurred or double vision.

  • Confusion, dizziness, lightheadedness, or drowsiness.

  • Swelling in the area where this medicine is applied.

  • Skin rash.

  • Chest pain, or an uneven heartbeat.

  • Trembling (shaking).

  • Tremors or seizures

  • Troubled or shallow breathing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Confusion, dizziness, sleepiness, lightheadedness

  • Hearing loss, ringing or buzzing in the ears (when applied into the middle ear)

  • Pale, gray, or blue lips, nails, or skin, dark urine, headache, unusual tiredness or weakness, fast heartbeat

Less Serious Side Effects

  • Swelling of the skin where the medicine was applied.

  • Redness, itching, burning, or swelling where the patch is applied

  • Pale or red skin where the medicine was applied.

  • Skin irritation, itching, redness, or pain.

  • Symptoms that do not improve in 7 days, or symptoms that get worse.

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