What is Cefotaxime Sodium: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Cefotaxime Sodium overview

BRAND NAMES:

  • Amerinet Claforan, Claforan, Claforan Novaplus

Generic Names:

  • Cefotaxime Sodium

Uses:

  • Treats infections caused by bacteria. This medicine is a cephalosporin antibiotic.

Therapeutic Classes:

  • Antibiotic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Cefotaxime Sodium used for?

What form(s) does Cefotaxime Sodium come in

  • Injectable

What are common Cefotaxime Sodium doses?

  • Solution Reconstituted 500MG

How to take Cefotaxime Sodium

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

What to do if you miss a dose of Cefotaxime Sodium

Cefotaxime Sodium contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to cefotaxime or any other cephalosporin antibiotic.

Cefotaxime Sodium warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or a history of stomach or bowel disease (such as colitis). Tell your doctor if you had an allergic reaction to penicillin.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Call your doctor if your symptoms do not improve or if they get worse.

Cefotaxime Sodium interactions

  • Some medicines can affect how cefotaxime works. Tell your doctor if you are using any of the following: Furosemide, probenecidAminoglycoside antibioticNSAID pain or arthritis medicine, including aspirin, celecoxib, diclofenac, ibuprofen, naproxen

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Cefotaxime Sodium side effects

Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Severe diarrhea (watery or bloody), severe stomach pain, nausea or vomiting

  • Unusual bleeding, bruising, or weakness

  • Fever, chills, cough, sore throat, and body aches