What is Crysvita: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Crysvita overview

BRAND NAMES:

  • Crysvita

Generic Names:

  • Crysvita

Uses:

  • Treats low phosphate levels in the blood.

Therapeutic Classes:

  • Phosphate Supplement

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Crysvita used for?

What form(s) does Crysvita come in

  • Injectable

What are common Crysvita doses?

  • Vial 1ML of 30MG/ML

Common Crysvita prescriptions

  • Crysvita
    1ml of 10mg/ml vial

  • Crysvita
    1ml of 20mg/ml vial

  • Crysvita
    1ml of 30mg/ml vial

How to take Crysvita

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is usually given in the upper arms, thighs, buttocks, or stomach.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is usually given in the upper arms, thighs, buttocks, or stomach.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

What to do if you miss a dose of Crysvita

Crysvita contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to burosumab-twza, or if you have severe kidney disease or end-stage kidney disease.

Crysvita warnings

  • This medicine may increase the phosphate level in your blood, which may increase your risk for nephrocalcinosis (high calcium level in the kidneys).

  • Tell your doctor if you are pregnant or breastfeeding, or if you have restless leg syndrome.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Crysvita interactions

  • You should not receive this medicine together with an oral phosphate or an active vitamin D analog (including calcifediol, calcitriol, doxercalciferol, paricalcitol).

Crysvita side effects

Serious Side Effects

  • Seizures, uneven heartbeat, mood or mental changes, muscle cramps, numbness and tingling around the mouth, fingertips, or feet

  • Fever, cough (in children)

  • Increased bone fractures, slowed growth

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Aching or discomfort in the lower legs or sensation of crawling in the legs

  • Dizziness, headache

  • Constipation, diarrhea, nausea, vomiting

  • Pain in the arms or legs (in children)

  • Toothache

  • Back pain

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