What is Dantrium: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Dantrium overview

BRAND NAMES:

  • Dantrium, Dantrolene Sodium, Dantrium, Revonto, Ryanodex

Generic Names:

  • Dantrolene Sodium

Uses:

  • Treats or prevents malignant hyperthermia (dangerous increase in body temperature). This medicine is a skeletal muscle relaxant., Treats muscle spasms. Also used to treat and prevent malignant hyperthermia.

Therapeutic Classes:

  • Skeletal Muscle Relaxant, Direct Acting, Skeletal Muscle Relaxant, Direct Acting

Forms:

  • Injectable, Capsule

How it’s taken:

  • By mouth, By injection

What is Dantrium used for?

Dantrium is a muscle relaxer that is used to treat muscle spasms caused by certain nerve disorders such as spinal cord injury, stroke, cerebral palsy, and multiple sclerosis. It works by reducing muscle pain and stiffness and improves your ability to move around.

What form(s) does Dantrium come in

  • Injectable

  • Capsule

What are common Dantrium doses?

  • Capsule 25MG

  • Capsule 50MG

Common Dantrium prescriptions

  • Dantrium
    25mg capsule

  • Dantrium
    50mg capsule

  • Dantrium
    20mg solution reconstituted

How to take Dantrium

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Dantrium

Dantrium contraindications

  • This medicine is not right for everyone. You should not use it if you had an allergic reaction to dantrolene, or if you have active liver disease (such as hepatitis or cirrhosis).

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to dantrolene.

Dantrium warnings

  • This medicine may cause the following problems:Muscle weaknessLung or breathing problemsTrouble swallowing

  • Tell your doctor if you are pregnant, or if you have kidney disease or liver disease.

  • Your doctor may tell you to stop breastfeeding, and pump and discard your breast milk for at least 3 days after you receive this medicine.

  • This medicine may make you lightheaded, drowsy, or dizzy. Do not drive or do anything else that could be dangerous if you are not alert for at least 48 hours after you receive this medicine.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have a history of liver disease, heart disease, or lung disease.

  • This medicine can cause the following problems: Liver problems

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous if you are not alert.

Dantrium interactions

  • Some medicines can affect how dantrolene works. Tell your doctor if you are also using any of the following: EstrogenHeart or blood pressure medicine

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous if you are not alert.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Some medicines can affect how dantrolene works. Tell your doctor if you are using any of the following: Clofibrate, tolbutamide, warfarinMedicine to lower blood pressure (including verapamil or CCBs)Medicine to treat anxiety or mental illnessOther medicine that relaxes the muscle (including tranquilizers)

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • This medicine may cause you to have trouble swallowing. To avoid choking, be careful when you eat on the day you receive this medicine.

Dantrium side effects

Serious Side Effects

  • Severe diarrhea

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fast, pounding, or uneven heartbeat, chest pain, trouble breathing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Cough, chest pain, trouble breathing

  • Lightheadedness, dizziness, drowsiness

  • Muscle weakness

Less Serious Side Effects

  • Changes in skin color, pain, tenderness, or swelling of the foot or leg

  • Pain, itching, burning, swelling, or a lump under your skin where the shot was given

  • Warmth or redness in your face, neck, arms, or upper chest

  • Dizziness, drowsiness, lightheadedness

  • Muscle weakness, tiredness

  • Mild diarrhea