What is Diltiazem Hcl Er Coated Beads: Uses, Warnings & Interactions

Updated May 19, 2025  •  Published Dec 30, 2020

The blood pressure medication diltiazem comes in several different extended-release formats. Two of those formats are capsules filled with extended-release beads or coated beads. Both release diltiazem over a 24-hour period. While diltiazem capsules with extended-release beads can be opened and the contents sprinkled on food, diltiazem capsules containing coated beads should not be opened. The only way to know if you are getting diltiazem coated beads is if the pharmacist tells you that the medicine is “generic Cartia XT” or “AB3-rated” diltiazem.

Diltiazem Hcl Er Coated Beads overview

BRAND NAMES:

  • Cardizem CD, Cartia XT

Generic Names:

  • Diltiazem HCl ER coated beads

Uses:

  • Treats high blood pressure and angina (chest pain).

Therapeutic Classes:

  • Antianginal, antihypertensive, calcium channel blocker

Forms:

  • 24-hour extended-release capsule

How it’s taken:

  • By mouth

What is Diltiazem Hcl Er Coated Beads used for?

Diltiazem HCl coated beads treat high blood pressure or chest pains (angina).

What form(s) does Diltiazem Hcl Er Coated Beads come in

  • 24-hour extended-release capsules

    • 120 mg

    • 180 mg

    • 240 mg

    • 300 mg

    • 360 mg

What are common Diltiazem Hcl Er Coated Beads doses?

  • For high blood pressure in adults: 180–480 mg capsules taken once daily

  • For angina in adults: 120–480 mg capsules taken once daily

Common Diltiazem Hcl Er Coated Beads prescriptions

  • dilTIAZem HCl ER Coated Beads
    30 capsules extended release 24 hour bottle

  • dilTIAZem HCl ER Coated Beads
    90 capsules extended release 24 hour bottle

  • dilTIAZem HCl ER Coated Beads
    100 capsules extended release 24 hour box

  • dilTIAZem HCl ER Coated Beads
    120mg capsule extended release 24 hour

  • dilTIAZem HCl ER Coated Beads
    180mg capsule extended release 24 hour

  • dilTIAZem HCl ER Coated Beads
    240mg capsule extended release 24 hour

  • dilTIAZem HCl ER Coated Beads
    300mg capsule extended release 24 hour

  • dilTIAZem HCl ER Coated Beads
    360mg capsule extended release 24 hour

How to take Diltiazem Hcl Er Coated Beads

  • Take this drug as instructed. The dose may need to be changed several times to find what works best for you.

  • Doses can be taken with or without food.

  • Take only one capsule each day.

  • Swallow the capsule or tablet whole with a glass of water. Do not crush, break, chew, or open the capsule or tablet.

  • Store diltiazem ER capsules in a closed, light-resistant container at room temperature. Protect the medicine from excessive humidity.

What to do if you miss a dose of Diltiazem Hcl Er Coated Beads

  • Ask the prescriber how to handle a missed dose.

  • Do not take extra medicine to make up for a missed dose.

Diltiazem Hcl Er Coated Beads contraindications

  • This medicine is not right for everyone. 

  • Do not use it if you have:

    • Known allergies to diltiazem

    • A heart rhythm problem called sick sinus syndrome without a pacemaker

    • Heart block without a pacemaker

    • Low blood pressure

  • Diltiazem is contraindicated in people who are having a heart attack with lung congestion.

Diltiazem Hcl Er Coated Beads warnings

  • Tell any healthcare provider or other healthcare provider who treats you that you are using this medicine.

  • Regular doctor’s visits and lab tests are needed to monitor therapy. Keep all appointments.

  • Before starting diltiazem ER treatment, tell the prescriber if you are pregnant, breastfeeding, or have:

    • Heart problems

    • Heart failure

    • Liver problems

    • Kidney problems

  • Diltiazem ER may cause serious problems including: 

    • Low blood pressure (hypotension)

    • Slow heart rate (bradycardia)

    • Heart rhythm changes

    • Heart attack

    • Worsening of heart failure

    • Peripheral edema

    • Liver damage

    • Severe skin reactions

  • Diltiazem can cause blood pressure to get dangerously low. This is more likely at the start of therapy or in dehydrated patients. Stand or sit up slowly if you feel lightheaded or dizzy.

  • Do not stop taking diltiazem ER until a doctor asks you to.

Diltiazem Hcl Er Coated Beads interactions

  • Diltiazem should never be taken with:

    • Cisapride

    • Flibanserin

    • Lomitapide

    • Lonafarnib

    • Pimozide

  • To avoid possible drug interactions, tell the prescriber about other drugs regularly used, particularly:

    • Other blood pressure drugs, especially beta blockers

    • Other drugs that treat heart rhythms or heartbeats, especially quinidine or digoxin

    • Cholesterol-lowering drugs called statins

    • Benzodiazepines

    • Barbiturates

    • Enlarged prostate medications called alpha blockers 

    • Cancer medications

    • Buspirone, carbamazepine, cimetidine, clarithromycin, clonidine, cyclosporine, ivabradine, lurasidone, rifampin

  • Tell other healthcare providers about diltiazem treatment before they prescribe new medications.

    • Tell the physician, surgeon, or healthcare team about diltiazem before any surgery or medical procedure that requires general anesthetics or ketamine. Diltiazem may need to be discontinued or the dose reduced a few days before the procedure.

  • Avoid drinking alcohol or grapefruit juice when taking diltiazem.

  • Avoid red yeast rice when taking diltiazem.

Find more information about diltiazem drug interactions to avoid here.

Diltiazem Hcl Er Coated Beads side effects

Serious side effects

Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Fast, slow, uneven, or pounding heartbeat

  • Dizziness, lightheadedness, and fainting

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Dark urine, clay-colored stools, appetite loss, nausea, vomiting, upper abdominal pain, yellow skin or eyes

  • Swelling in your hands, ankles, or legs

  • Blistering, peeling, red skin rash

  • Allergic reaction: Itching, rash, hives, swelling in the face, mouth, lips, or throat, trouble breathing

Less serious side effects

  • Headache

  • Dizziness

  • Slow heart rate

  • Fatigue

  • Runny nose

Find more information about diltiazem side effects here.

Sources:

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.