What is Doxylamine-Pyridoxine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Doxylamine-Pyridoxine overview

BRAND NAMES:

  • Diclegis, Bonjesta

Generic Names:

  • Doxylamine-Pyridoxine

Uses:

  • Treats nausea and vomiting during pregnancy (also called morning sickness).

Therapeutic Classes:

  • Gastrointestinal Agent, Antiemetic, Antihistamine Combination

Forms:

  • Long Acting Tablet, Delayed Release Tablet

How it’s taken:

  • By mouth

What is Doxylamine-Pyridoxine used for?

What form(s) does Doxylamine-Pyridoxine come in

  • Long Acting Tablet

  • Delayed Release Tablet

What are common Doxylamine-Pyridoxine doses?

  • Tablet 10mg/10mg

  • Tablet Delayed Release 10-10MG

Common Doxylamine-Pyridoxine prescriptions

  • Doxylamine-Pyridoxine
    10mg/10mg tablet

  • Doxylamine-Pyridoxine
    10-10mg tablet delayed release

How to take Doxylamine-Pyridoxine

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine on an empty stomach.

  • Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeIt is best to take this medicine on an empty stomach.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.

What to do if you miss a dose of Doxylamine-Pyridoxine

Doxylamine-Pyridoxine contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to doxylamine, pyridoxine, or similar medicines, or if you are breastfeeding.

Doxylamine-Pyridoxine warnings

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you have asthma, glaucoma, trouble urinating, or stomach or bowel problems (including blockage or ulcer).

  • This medicine may make you drowsy or sleepy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Doxylamine-Pyridoxine interactions

  • Do not use this medicine together with an MAO inhibitor (MAOI).

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Doxylamine-Pyridoxine side effects

Serious Side Effects

  • Severe dizziness, lightheadedness, or sleepiness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

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