What is Drysol: Uses, Warnings & Interactions

Updated Jul 11, 2025  •  Published Dec 30, 2020

Drysol is a prescription antiperspirant that reduces excessive sweating (hyperhidrosis). The active ingredient is aluminum chloride hexahydrate, a chemical that forms a “plug” over sweat glands when it comes in contact with water. Over time, the drug also shrinks the size of sweat glands and reduces sweating.

Drysol overview

BRAND NAMES:

  • Drysol, Drysol Dab-On, Drysol Mild, Drysol Regular, Drysol Extra-Strength

Generic Names:

  • Aluminum chloride hexahydrate

Uses:

  • Reduces excessive sweating

Therapeutic Classes:

  • Antiperspirant

Forms:

  • Topical solution (liquid)

How it’s taken:

  • On the skin

What is Drysol used for?

Drysol treats hyperhidrosis (excessive sweating), which is resistant to over-the-counter antiperspirants.

What form(s) does Drysol come in

  • Topical solution 

    • 6.25%

    • 12%

    • 20%

What are common Drysol doses?

  • For the treatment or prevention of excessive underarm sweating: Apply once daily to the underarms or other affected areas at bedtime until sweating is under control, and then apply once or twice weekly at bedtime

Common Drysol prescriptions

  • Drysol
    35ml of 20% bottle

  • Drysol
    37.5ml of 20% bottle

  • Drysol
    60ml of 20% bottle

How to take Drysol

  • Follow all the prescriber’s instructions.

  • Apply doses at bedtime.

  • Start by applying doses once daily until sweating is under control.

    • This usually takes two doses to get sweating under control

    • Once sweating is under control, apply maintenance doses once or twice weekly. 

    • Sweating will gradually reduce over time, so the dermatologist may suggest spacing doses out more.

  • Only apply the medicine to dry skin. Applying it to wet skin may cause burning and irritation.

  • Do not apply Drysol to broken, irritated, or recently-shaven skin.

  • After the application, put on a snug-fitting T-shirt or similar clothing to protect your bed linens.

    • If applied to the feet or hands, wear something over them when going to bed.

    • Allow the medication to dry completely before putting on clothing.

  • Store Drysol at room temperature as you do other antiperspirants.

What to do if you miss a dose of Drysol

  • Do not worry about a missed dose. 

  • If a dose is missed, apply it the next day at bedtime.

Drysol contraindications

  • You should not use this medicine if you have had an allergic reaction to aluminum or to products containing aluminum chloride.

Drysol warnings

  • Before starting Drysol, make sure the prescriber knows if you are pregnant or breastfeeding.

  • Use Drysol only on the skin. Do not swallow it or get it in the eyes. 

    • Call a poison control center if Drysol is ingested.

  • Stop using Drysol and contact the prescriber if you experience severe burning or irritation.

  • Drysol is an alcohol solution, and the active ingredient is acidic when it comes in contact with water. Skin irritation is a common complaint. Ask the prescriber how to manage excessive irritation.

  • Drysol can stain fabrics and react with metal, so take precautions.

Drysol interactions

  • Drysol has no significant drug interactions.

  • You may use a daily deodorant or antiperspirant in the mornings, but ask the prescriber first.

Drysol side effects

Serious side effects

Talk to a healthcare provider if you notice any signs or symptoms of a possible serious side effect, including:

  • Severe skin irritation or burning

  • Allergic reaction: Rash, itching, blistering, dizziness, trouble breathing, swelling of the face, lips, mouth, tongue, or throat

Less serious side effects

  • Skin irritation

  • Itching

Sources:

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