Drysol is a prescription antiperspirant that reduces excessive sweating (hyperhidrosis). The active ingredient is aluminum chloride hexahydrate, a chemical that forms a “plug” over sweat glands when it comes in contact with water. Over time, the drug also shrinks the size of sweat glands and reduces sweating.
Drysol, Drysol Dab-On, Drysol Mild, Drysol Regular, Drysol Extra-Strength
Aluminum chloride hexahydrate
Reduces excessive sweating
Antiperspirant
Topical solution (liquid)
On the skin
Drysol treats hyperhidrosis (excessive sweating), which is resistant to over-the-counter antiperspirants.
Topical solution
6.25%
12%
20%
For the treatment or prevention of excessive underarm sweating: Apply once daily to the underarms or other affected areas at bedtime until sweating is under control, and then apply once or twice weekly at bedtime
Drysol
35ml of 20% bottle
Drysol
37.5ml of 20% bottle
Drysol
60ml of 20% bottle
Follow all the prescriber’s instructions.
Apply doses at bedtime.
Start by applying doses once daily until sweating is under control.
This usually takes two doses to get sweating under control
Once sweating is under control, apply maintenance doses once or twice weekly.
Sweating will gradually reduce over time, so the dermatologist may suggest spacing doses out more.
Only apply the medicine to dry skin. Applying it to wet skin may cause burning and irritation.
Do not apply Drysol to broken, irritated, or recently-shaven skin.
After the application, put on a snug-fitting T-shirt or similar clothing to protect your bed linens.
If applied to the feet or hands, wear something over them when going to bed.
Allow the medication to dry completely before putting on clothing.
Store Drysol at room temperature as you do other antiperspirants.
Do not worry about a missed dose.
If a dose is missed, apply it the next day at bedtime.
You should not use this medicine if you have had an allergic reaction to aluminum or to products containing aluminum chloride.
Before starting Drysol, make sure the prescriber knows if you are pregnant or breastfeeding.
Use Drysol only on the skin. Do not swallow it or get it in the eyes.
Call a poison control center if Drysol is ingested.
Stop using Drysol and contact the prescriber if you experience severe burning or irritation.
Drysol is an alcohol solution, and the active ingredient is acidic when it comes in contact with water. Skin irritation is a common complaint. Ask the prescriber how to manage excessive irritation.
Drysol can stain fabrics and react with metal, so take precautions.
Drysol has no significant drug interactions.
You may use a daily deodorant or antiperspirant in the mornings, but ask the prescriber first.
Talk to a healthcare provider if you notice any signs or symptoms of a possible serious side effect, including:
Severe skin irritation or burning
Allergic reaction: Rash, itching, blistering, dizziness, trouble breathing, swelling of the face, lips, mouth, tongue, or throat
Skin irritation
Itching
Aluminum—allergen of the year 2022, Dermatitis
Aluminum chloride hexahydrate, Memorial Sloan Kettering Cancer Center
Drysol Dab-O-Matic 20% topical solution, Kaiser Permanente
Drysol drug summary, Prescriber’s Digital Reference (PDR)
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