What is Duavee: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Duavee overview

BRAND NAMES:

  • Duavee

Generic Names:

  • Duavee

Uses:

  • Treats hot flashes during menopause. Also prevents osteoporosis after menopause.

Therapeutic Classes:

  • Endocrine-Metabolic Agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Duavee used for?

Duavee comes in the form of a tablet and is used to treat moderate to severe hot flashes associated with menopause. Duavee uses a combination of conjugated estrogens and bazedoxifene to relieve hot flashes and helps to protect the lining of the uterus from thickening. Estrogen is the female sex hormone and conjugated estrogens are a mixture of estrogen hormones. Common side effects may include mild dizziness, nausea and stomach pain.

What form(s) does Duavee come in

  • Tablet

What are common Duavee doses?

  • Tablet 0.45-20MG

Common Duavee prescriptions

  • Duavee
    0.45-20mg tablet

How to take Duavee

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Swallow the tablet whole. Do not crush, break, or chew it.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep your medicine in the original package until you are ready to use it. Do not place the tablets in pill boxes or pill organizers. Use the medicine within 60 days after you open the foil pouch.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor may also want you to take vitamin D and calcium supplements.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor may also want you to take vitamin D and calcium supplements.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep your medicine in the original package until you are ready to use it. Do not place the tablets in pill boxes or pill organizers. Use the medicine within 60 days after you open the foil pouch.

  • Swallow the tablet whole. Do not crush, break, or chew it.

What to do if you miss a dose of Duavee

Duavee contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to bazedoxifene or conjugated estrogens, or if you are pregnant or breastfeeding. Do not use it if you have had problems with blood clots (including deep vein thrombosis or stroke) or if you have liver disease.

Duavee warnings

  • Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.

  • Tell your doctor if you had a heart attack, have bleeding problems, or had any kind of cancer (especially breast or uterine cancer).

  • Tell your doctor if you have kidney disease, heart disease, asthma, diabetes, epilepsy, gallbladder disease, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high blood cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, or if you smoke.

  • This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsHigher risk of endometrial cancer, breast cancer, or uterine cancerHigher risk of dementia, especially in women 65 years of age and older

  • You may need to stop using this medicine for a few weeks before and after you have surgery or if you need to stay in bed for a long time, because of the risk of blood clots.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Vision changes, vision loss, double vision, migraine headache

Duavee interactions

  • Do not take other medicines that contain estrogen or progestin while you are being treated with this medicine.

  • Some foods and medicines can affect how Duavee® works. Tell your doctor if you are using carbamazepine, clarithromycin, erythromycin, itraconazole, ketoconazole, phenobarbital, phenytoin, rifampin, ritonavir, or St John's wort.

  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

  • This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsHigher risk of endometrial cancer, breast cancer, or uterine cancerHigher risk of dementia, especially in women 65 years of age and older

  • You may need to stop using this medicine for a few weeks before and after you have surgery or if you need to stay in bed for a long time, because of the risk of blood clots.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Duavee side effects

Serious Side Effects

  • Coughing up blood

  • Sudden or severe stomach pain, nausea, or vomiting

  • Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting

  • Sudden or severe headache

  • Vision changes, vision loss, double vision, migraine headache

  • Breast lumps

  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking

  • Unusual or unexpected vaginal bleeding or heavy bleeding

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Mild diarrhea, nausea, stomach pain or upset

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