What is Duobrii: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Duobrii overview

BRAND NAMES:

  • Duobrii

Generic Names:

  • Duobrii

Uses:

  • Treats plaque psoriasis. This medicine contains a corticosteroid.

Therapeutic Classes:

  • Corticosteroid, Very Strong

Forms:

  • Lotion

How it’s taken:

  • On the skin

What is Duobrii used for?

What form(s) does Duobrii come in

  • Lotion

What are common Duobrii doses?

  • Tube 100GM of 0.01-0.045%

Common Duobrii prescriptions

  • Duobrii
    100gm of 0.01-0.045% tube of lotion

How to take Duobrii

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine is for use on the skin only. Do not get it near your eyes, nose, mouth, underarms, groin, or genitals. If it does get on these areas, rinse it off right away.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Make sure your skin is dry before you use the medicine. Apply a thin layer only to the affected area. Rub it in gently.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine is for use on the skin only. Do not get it near your eyes, nose, mouth, underarms, groin, or genitals. If it does get on these areas, rinse it off right away.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Make sure your skin is dry before you use the medicine. Apply a thin layer only to the affected area. Rub it in gently.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze.

What to do if you miss a dose of Duobrii

Duobrii contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to halobetasol or tazarotene, or if you are pregnant.

Duobrii warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. You must have a negative pregnancy test within 2 weeks before you start using this medicine. Your doctor may tell you to start using the medicine during your menstrual period.

  • Tell your doctor if you are breastfeeding, or if you have liver disease, adrenal gland problems, diabetes, eye problems, eczema, other skin problems, sunburn, or any type of skin infection.

  • This medicine may cause the following problems:Cushing syndromeHigh blood sugarEye or vision problems (including cataracts, glaucoma)

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

  • This medicine makes your skin more sensitive to irritation and more likely to burn. Avoid exposing your skin to wind, cold weather, and sunlight, even on cloudy days. Do not use a sunlamp or tanning bed. Use a sunscreen or sunblock lotion with a sun protection factor (SPF) of at least 15 on a regular basis. Wear protective clothing when you are outside.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Duobrii interactions

  • Some medicines can affect how halobetasol/tazarotene works. Tell your doctor if you are using any of the following:Antibiotic (including ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, tetracycline)Diuretic (water pill)Other steroid medicinesPhenothiazine medicineSulfa medicine

Duobrii side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blisters, swelling, rash, or red, scaly, crusty skin

  • Blurred vision or other changes in vision, eye pain

  • Color changes on the skin, dark freckles, easy bruising, muscle weakness

  • Round, puffy face

  • Severe skin itching, burning, redness, peeling, or pain

  • Weight gain around your neck, upper back, breast, face, or waist

Less Serious Side Effects

  • Mild skin itching, peeling, stinging, burning, or dryness