What is Enhertu: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Enhertu overview

BRAND NAMES:

  • Enhertu

Generic Names:

  • Enhertu

Uses:

  • Treats breast cancer.

Therapeutic Classes:

  • Immunological Agent, Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Enhertu used for?

What form(s) does Enhertu come in

  • Injectable

What are common Enhertu doses?

  • Solution Reconstituted 100MG

Common Enhertu prescriptions

  • Enhertu
    100mg solution reconstituted

How to take Enhertu

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be given slowly, so the needle will have to stay in place for at least 30 to 90 minutes.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be given slowly, so the needle will have to stay in place for at least 30 to 90 minutes.

What to do if you miss a dose of Enhertu

Enhertu contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to trastuzumab or fam-trastuzumab deruxtecan-nxki, or if you are pregnant.

Enhertu warnings

  • Do not breastfeed during treatment with this medicine and for 7 months after the last dose.

  • This medicine may cause the following problems:Lung problemsNew or worsening heart failure

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Injection routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Female patients should use an effective form of birth control during treatment and for 7 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 4 months after the last dose.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Tell your doctor if you have kidney disease, liver disease, lung disease, or history of heart disease.

  • Talk with your doctor before receiving this medicine if you plan to have children. Some men and women who receive this medicine have become infertile (unable to have children).

Enhertu interactions

Enhertu side effects

Serious Side Effects

  • Fever, chills, cough, sore throat, body aches

  • Unusual bleeding, bruising, or weakness

  • Chest pain, trouble breathing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Rapid weight gain, swelling in your hands, ankles, or feet

Less Serious Side Effects

  • Constipation, diarrhea, nausea, vomiting

  • Pain, redness, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Hair loss

  • Decreased appetite, tiredness

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