Epclusa is an antiviral prescription medication used to treat hepatitis C, which is an infection of the liver caused by a virus. The generic version of this drug is sofosbuvir-velpatasvir. The average retail price of Epclusa is about $31,510.52 for 28, 400-100mg tablets. Pay a lower cost of $7,806.75 for 1, 28 tablets box by using SingleCare’s coupon program. This coupon can be redeemed for cash savings at participating local pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Epclusa is an antiviral prescription medication used to treat hepatitis C, which is an infection of the liver caused by a virus. The generic version of this drug is sofosbuvir-velpatasvir. The average retail price of Epclusa is about $31,510.52 for 28, 400-100mg tablets. Pay a lower cost of $7,806.75 for 1, 28 tablets box by using SingleCare’s coupon program. This coupon can be redeemed for cash savings at participating local pharmacies.
Epclusa is an antiviral prescription medication used to treat hepatitis C, which is an infection of the liver caused by a virus. The generic version of this drug is sofosbuvir-velpatasvir. The average retail price of Epclusa is about $31,510.52 for 28, 400-100mg tablets. Pay a lower cost of $7,806.75 for 1, 28 tablets box by using SingleCare’s coupon program. This coupon can be redeemed for cash savings at participating local pharmacies.
Usually the cost of Epclusa, without insurance coverage, is around $31,510.52 for 28, 400-100mg tablets or sometimes more. SingleCare’s discount program can help you to save on this total with a Epclusa coupon. Pay just $7,806.75 for 1, 28 tablets box for your Epclusa purchase when you use SingleCare’s Epclusa coupon at participating drugstores. You can access free SingleCare cards and coupons on our website or mobile app.
The cost of Epclusa with insurance may vary based on the type of health insurance plan that you are enrolled in. Contact your health plan directly to find out exactly how much Epclusa costs under your current insurance plan. SingleCare can help you to easily save on your Epclusa purchases. Pay only $7,806.75 for 1, 28 tablets box for your Epclusa purchase when you use SingleCare’s Epclusa savings card.
Epclusa is covered by most Medicare Part D plans and Medicare Advantage plans. SingleCare can help to lower your out-of-pocket costs from Epclusa to $7,806.75 for 1, 28 tablets box. Just use your SingleCare savings card at participating local pharmacies to claim these savings.
Epclusa is a brand-name prescription drug manufactured by Gilead Sciences Inc. The generic version of this drug is sofosbuvir-velpatasvir.
Epclusa is an FDA-approved prescription medication used to treat hepatitis C, which is an infection of the liver caused by a virus. This medication works by reducing the amount of hepatitis C virus in your body. This helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring or liver cancer.
Epclusa can be used in adults and children 3 years and older. Epclusa treats certain genotypes of hepatitis C. Your healthcare provider will order tests to make sure Epclusa is the appropriate treatment for you.
Epclusa may also be used with ribavirin to treat scarring of the liver.
Epclusa is sometimes used in patients who also have HIV. However, Epclusa does not treat HIV or AIDS.
Read the instructional leaflet and Medication Guide provided with this medication before you begin use. This medication comes in the form of an oral tablet that can be taken with or without food. It is also available as a pellet that comes in a packet and can be taken directly in the mouth or mixed with a spoonful of soft food, like pudding. The pellets should not be chewed.
Take your medication daily as directed. Continue using this medication until your full prescription is complete, even if your symptoms go away early. Stopping this medication too early may result in a return of your infection. Refill your prescription several days before you need it, so that you do not run out.
Before taking Epclusa, tell your doctor about all of your medical conditions, especially if you:
Are breastfeeding
Are a hepatitis B virus carrier
Are immunocompromised
Have diabetes
Have both a hepatitis B and hepatitis C infection
Tell your doctor about any allergies to medications, and all of the medications you take, including prescription and over-the-counter drugs, vitamins, and supplements. Epclusa interacts with certain drugs, such as the antibiotic rifampin, the supplement St. John’s Wort, and the anticonvulsant Tegretol (carbamazepine). Epclusa also interacts with antacids. If you need to take an antacid, then use it at least four hours after using Epclusa.
Other drug interactions may occur. Consult your healthcare provider for a full list of drug interactions.
Epclusa may cause side effects such as nausea, diarrhea, headaches, tiredness, weakness, irritability, or difficulty sleeping. Talk to your doctor if you experience any of these effects and they persist or worsen. Many patients using this medication do not have serious side effects.
Serious allergic reactions to this medication are usually rare. However, you should seek emergency medical attention if you begin to experience symptoms of a serious allergic reaction such as hives, trouble breathing, or swelling of the face, lips, tongue, or throat.
If you have previously had hepatitis B, it may come back or worsen. Call your healthcare professional if you have upper stomach pain, vomiting, appetite loss, or yellowing of the skin and whites of the eyes.
Talk to your doctor or healthcare provider for full medical advice on the risks and benefits involved with using Epclusa as this is not a complete list of side effects.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved