Esterified estrogens and methyltestosterone is a generic prescription drug that combines both female and male sex hormones. It helps relieve menopausal symptoms in women who are not responding to estrogen replacement alone. Because of the risks, doctors prescribe the lowest possible dose and attempt to stop the treatment as soon as it’s feasible. Tablets are taken cyclically—three weeks on, one week off.
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Esterified Estrogens-Methyltestosterone overview
BRAND NAMES:
Estratest H.S.
Generic Names:
Esterified estrogens and methyltestosterone
Uses:
Treats vasomotor symptoms of menopause such as hot flashes.
Therapeutic Classes:
Estrogen/Androgen Combination
Forms:
Tablet
How it’s taken:
By mouth
What is Esterified Estrogens-Methyltestosterone used for?
The combination drug, esterified estrogens and methyltestosterone, treats the vasomotor symptoms of menopause such as hot flashes and night sweats. Clinicians use it only when estrogen replacement therapy is not working to control these symptoms.
What form(s) does Esterified Estrogens-Methyltestosterone come in
Tablet
0.625 mg esterified estrogens/1.25 mg methyltestosterone
1.25 mg/2.5 mg
What are common Esterified Estrogens-Methyltestosterone doses?
For refractory moderate to severe vasomotor symptoms of menopause: one to two tablets at the lowest possible dose daily on a cyclical cycle of three weeks of treatment and one week off.
Common Esterified Estrogens-Methyltestosterone prescriptions
Est Estrogens-Methyltest
0.625-1.25mg tabletEst Estrogens-Methyltest
1.25-2.5mg tablet
How to take Esterified Estrogens-Methyltestosterone
Take this medicine as instructed. The doctor will tell you how much medicine to take and how often.
If the doctor has also prescribed a progestogen, take that medicine as instructed.
Take the tablets with food to minimize the risk of nausea.
Swallow the tablet with a drink of water.
Store the tablets in a closed container at room temperature. Keep the tablets out of the reach of children.
What to do if you miss a dose of Esterified Estrogens-Methyltestosterone
Ask the prescriber what to do if a dose is missed.
You should not take two doses to compensate for a missed dose.
Esterified Estrogens-Methyltestosterone contraindications
This medicine is not right for everyone. Do not use it if you have had a severe allergic reaction to estrogens, are pregnant, breastfeeding, or have:
Severe liver disease
Unusual vaginal bleeding that has not been checked by a doctor
Breast cancer or a history of breast cancer (except in people being treated for metastatic breast cancer)
Any other cancer that is estrogen-dependent such as uterine or ovarian cancer
Active or past blood clots
Recent stroke or heart attack
Esterified Estrogens-Methyltestosterone warnings
It is not safe to take esterified estrogens and methyltestosterone while pregnant or breastfeeding. Tell the prescriber right away if you become pregnant or plan to breastfeed.
Tell any doctor or other healthcare provider who treats you that you are using this medicine. You may need to stop using this medicine several days before surgery, some types of medical tests, or prolonged bed rest.
The doctor will need to check on your progress every three to six months to determine if it’s still useful and safe to take this drug. Keep all appointments.
Make sure to tell the prescriber if you are pregnant, breastfeeding, or have:
Endometriosis
Heart problems
Liver problems
Kidney problems
Thyroid problems
Asthma
Epilepsy
Migraine
High calcium
High blood pressure
High cholesterol
Diabetes
Porphyria
Estrogen and methyltestosterone therapy can cause serious problems including:
Heart attack
Stroke
Blood clot problems
Breast cancer
Ovarian cancer
Uterine cancer
Gallbladder disease
Liver dysfunction
Severe and potentially life-threatening liver disease
Dementia
High blood pressure
High blood sugar
High calcium
Low thyroid hormones (hypothyroidism)
Fluid retention
Esterified Estrogens-Methyltestosterone interactions
To avoid possible drug interactions, tell the prescriber about all the prescription drugs, over-the-counter medications, and supplements being taken, particularly:
Other female hormones
Blood thinners
Insulin
Tell other healthcare providers you are using this medicine before they prescribe new medications.
Esterified Estrogens-Methyltestosterone side effects
Serious side effects
Immediately contact a doctor or get medical attention if you notice any signs or symptoms of a possible serious side effect including:
Unusual vaginal bleeding
New breast lumps, breast discharge
Swelling in your face, hands, ankles, or feet
Sudden or severe headache, numbness or weakness on one side of your body, problems with vision, speech, or walking
Leg pain
Vision changes
Acne, hoarseness, voice changes, menstrual period changes, unwanted facial hair
Seizures
Yellow skin or eyes
Vomiting
Shortness of breath
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Less Serious Side Effects
Headache
Breast pain
Irregular vaginal bleeding
Abdominal cramps
Bloating
Nausea
Vomiting
Hair loss
Sources:
EEMT HS drug summary, Prescriber’s Digital Reference (PDR)
Esterified estrogens and methyltestosterone tablet prescribing information, DailyMed (NIH National Library of Medicine)
Estratest H.S. esterified estrogens and methyltestosterone tablet prescribing information, DailyMed (NIH National Library of Medicine)
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