Estriol is a weak estrogen, a female hormone, that is prescribed as hormone replacement therapy to menopausal women with a uterus to reduce physical changes caused by menopause. These changes include hot flashes, night sweats, vaginal dryness, and bone loss. Estriol is also available over-the-counter as Estriol vaginal cream. Estriol's price is $828.59 for 1.20, 25gm of bottles and is usually available only at compounding pharmacies. You may get a discounted price as low as $11,325.41 with a SingleCare Estriol coupon if the pharmacy you use dispenses Estriol.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Estriol is a weak estrogen, a female hormone, that is prescribed as hormone replacement therapy to menopausal women with a uterus to reduce physical changes caused by menopause. These changes include hot flashes, night sweats, vaginal dryness, and bone loss. Estriol is also available over-the-counter as Estriol vaginal cream. Estriol's price is $828.59 for 1.20, 25gm of bottles and is usually available only at compounding pharmacies. You may get a discounted price as low as $11,325.41 with a SingleCare Estriol coupon if the pharmacy you use dispenses Estriol.
Estriol is a weak estrogen, a female hormone, that is prescribed as hormone replacement therapy to menopausal women with a uterus to reduce physical changes caused by menopause. These changes include hot flashes, night sweats, vaginal dryness, and bone loss. Estriol is also available over-the-counter as Estriol vaginal cream. Estriol's price is $828.59 for 1.20, 25gm of bottles and is usually available only at compounding pharmacies. You may get a discounted price as low as $11,325.41 with a SingleCare Estriol coupon if the pharmacy you use dispenses Estriol.
Uninsured customers pay an average of $828.59 and Estriol is mainly purchased from compounding pharmacies. However, you may be able to purchase Estriol at your pharmacy. If so, you could pay only $11,325.41 with a SingleCare Estriol coupon. On your other prescriptions, a SingleCare discount card can reduce prices up to 80%.
Estriol copay costs may vary depending on your insurance plan. With SingleCare, Estriol costs $11,325.41, which may be lower than your copay. So, while you will probably purchase Estriol from a compounding pharmacy, you might be able to fill your prescription at your favorite pharmacy. So ask your pharmacist if you can fill your Estriol prescription and then ask to compare your insurance Estriol price with the SingleCare discount card.
Estriol is not covered by Medicare prescription drug plans. Patients without Medicare can rely on their SingleCare Estriol coupon if their pharmacy will fill their Estriol prescription. SingleCare reduces the price of Estriol to $11,325.41. Our free and reusable coupons for all prescription drugs are accepted at many participating pharmacies located near you, like Target, Walmart, and Duane Reade.
In the United States, Estriol is a generic prescription drug available from compounding pharmacies only. There are no brand-name versions in the U.S.
Over-the-counter Estriol cream is available under several brand names, such as Emerita and Life-Flo Estriol-Care, both from NutraMarks. Estriol cream is widely available in Europe as a prescription cream in both brand-name and generic formulas.
Estriol is a female hormone, estrogen, that is prescribed as hormone replacement therapy to menopausal women with a uterus to reduce physical changes caused by menopause. These changes include hot flashes, night sweats, vaginal dryness, and bone loss. Estriol is a weak estrogen compared to estradiol and estrone, the other two estrogens produced by the body. Because of this, Estriol is used as a “gentler” hormone replacement therapy that has fewer and less severe side effects.
Although widely available in Europe, Estriol is rarely prescribed in the United States because other, more effective drugs are available. In particular, Estriol has not been shown to consistently help with improving osteoporosis.
Estriol is administered as a capsule, lozenge, cream, gel, or vaginal suppository. Estriol is available in the United States as non-prescription Estriol cream to specifically treat vaginal dryness, itching, and irritation due to menopause. Estriol cream is applied directly to the vaginal tissues.
Common side effects of Estriol include but are not limited to breast tenderness, vaginal discomfort, nausea, vomiting, stomach cramps, headache, migraine, bloating, weight changes, and thinning hair. Allergic reactions are uncommon, but they include rashes or hives. Mood changes are rare but include anxiety, nervousness, irritability, and depression.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved