Hydrea Coupons & Prices

Hydroxyurea

Hydrea is a brand-name prescription drug that is used to treat a certain type of leukemia (chronic myeloid leukemia) and head and neck cancers. The active ingredient in Hydrea, hydroxyurea, blocks the ability of cancer cells to produce or use DNA, preventing the cancer cells from growing. Hydroxia, the active ingredient of Hydrea, is also used to treat sickle cell disease. Hydrea normally costs $681.09 at full retail price. A SingleCare Hydrea coupon reduces that price to $17.89.

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Hydrea coupon at Kroger Pharmacy
$20.89
$ 17.89
$3 off with signupwith signup

Show this free card to your pharmacist.

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Hydrea coupon at Harris Teeter Pharmacy
$20.89
$ 17.89
$3 off with signupwith signup

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Hydrea coupon at Costco Pharmacy
$ 23.99
Hydrea coupon at Food Lion Pharmacy
$ 24.80
Hydrea coupon at Walmart Neighborhood Market Pharmacy
$29.39
$ 26.39
$3 off with signupwith signup
Hydrea coupon at Walmart Pharmacy
$29.39
$ 26.39
$3 off with signupwith signup
$29.59
$ 26.59
$3 off with signupwith signup
$29.76
$ 26.76
$3 off with signupwith signup
$ 29.95

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 02/03/2026

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About Hydrea

Hydrea is a brand-name prescription drug that is used to treat a certain type of leukemia (chronic myeloid leukemia) and head and neck cancers. The active ingredient in Hydrea, hydroxyurea, blocks the ability of cancer cells to produce or use DNA, preventing the cancer cells from growing. Hydroxia, the active ingredient of Hydrea, is also used to treat sickle cell disease. Hydrea normally costs $681.09 at full retail price. A SingleCare Hydrea coupon reduces that price to $17.89.

Hydrea Price History & Information

Price History for Hydrea (Brand) & Hydroxyurea (Generic)

60 count, capsule, 500mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Hydrea (Brand) & Hydroxyurea (Generic)

60 count, capsule, 500mg
PharmacyHydroxyurea Retail PriceHydroxyurea SingleCare Price
CVS Pharmacy$78.49$28.80
Walmart$25.00$24.20
Walgreens$18.60$12.00
Kroger Pharmacy$60.00$21.00

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Hydrea

Hydrea is a brand-name prescription drug that is used to treat a certain type of leukemia (chronic myeloid leukemia) and head and neck cancers. The active ingredient in Hydrea, hydroxyurea, blocks the ability of cancer cells to produce or use DNA, preventing the cancer cells from growing. Hydroxia, the active ingredient of Hydrea, is also used to treat sickle cell disease. Hydrea normally costs $681.09 at full retail price. A SingleCare Hydrea coupon reduces that price to $17.89.

Hydrea FAQs

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

How much does Hydrea cost without insurance?

The pharmacy cost of Hydrea will be $681.09. That same prescription will cost $17.89 per 60, 500mg capsules using a SingleCare savings card, which you can use at major pharmacies throughout the country, such as CVS, Target, Longs Drugs, Walmart, and other pharmacies located near you.

How much does Hydrea cost with insurance?

The cost of Hydrea with insurance will depend on a number of factors, including the insurance plan’s formulary and the dosage prescribed. With a SingleCare discount card, Hydrea will cost $17.89. That's why it's a good idea to ask your pharmacist to compare your Hydrea insurance copay to your SingleCare Hydrea coupon for the lowest prices. You might save more with SingleCare.

Does Medicare cover Hydrea and how much does it cost?

Medicare Advantage and Medicare Part D prescription drug insurance plans usually do not provide coverage for Hydrea, but most Medicare plans will cover the generic version of Hydrea, hydroxyurea. If you don't have coverage for Hydrea, consider using a SingleCare free coupon for your prescription. With SingleCare, the price of Hydrea is $17.89 for 60, 500mg capsules.

Is there a generic of Hydrea?

Hydrea is a brand-name prescription drug. Generic Hydrea is available as hydroxyurea from different manufacturers including Barr, Leading Pharma, and Par Pharmaceutical. If you have any questions about hydroxyurea, make sure you search the SingleCare website or app for drug information or valuable savings coupons.

What is Hydrea?

The active ingredient in Hydrea, hydroxyurea, blocks the ability of cancer cells to produce DNA needed to replicate, so the cancer cells eventually stop growing and die off. Hydroxyurea also helps prevent the development of sickle-shaped red blood cells in those with sickle cell anemia.

Hydrea is taken as a capsule. Dosage is based on body weight and other factors such as tumor type, severity of disease, and response to treatment.

What are the side effects of Hydrea?

Common side effects of Hydrea include, but are not limited to, temporary hair loss, headache, drowsiness, dizziness, nausea, vomiting, upset stomach, diarrhea, constipation, and flu symptoms. Consult a healthcare provider if you experience side effects or they persist or worsen. 

Serious side effects of Hydrea include low red blood cell counts, low white blood cell counts, and low platelet counts. Seek medical advice from your healthcare provider if you experience fever, body aches, or chills. Some people have experienced cancer, such as leukemia, after taking Hydrea. Skin ulcers have also been reported in some people who have a history of using interferon therapy.

Allergic reactions are rare. Watch for signs of an allergic reaction, including swelling, itching, or rash, and seek immediate medical attention if you experience what you believe to be an allergic reaction.

Tell your healthcare professional if you have a history of kidney or liver problems, HIV, increased uric acid levels, or if you are pregnant or breastfeeding before taking Hydrea. 

This is not a complete list of possible side effects. Consult with your physician or pharmacist if you have concerns or questions about side effects or other negative drug interactions.

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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Where are Hydrea coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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