Hyosyne Coupons & Prices

Hyoscyamine Sulfate

Hyosyne is a prescription smooth muscle relaxant in elixir and drops format that treats, as a secondary medication, the symptoms of a broad spectrum of disorders, including intestinal problems, stomach ulcers, kidney stones, gallstones, Parkinson's muscle rigidity, diarrhea, and intestinal spasms, among others. In drops format, Hyosyne is prescribed to treat infant colic. The active ingredient in Hyosyne, hyoscyamine, relaxes the smooth muscles that cause many of these symptoms. Hyosyne normally retails for $70.37, but SingleCare offers a free Hyosyne coupon that may significantly reduce Hyosyne's cost to $30.72.

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30 elixir (quantity in ml)0.125mg/5mlEdit

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Hyosyne coupon at CVS Pharmacy
$33.72
$ 30.72
$3 off with signupwith signup

Show this free card to your pharmacist.

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Hyosyne coupon at Walgreens Pharmacy
$36.98
$ 33.98
$3 off with signupwith signup

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Hyosyne coupon at Food Lion Pharmacy
$ 47.60
Hyosyne coupon at Kroger Pharmacy
$54.43
$ 51.43
$3 off with signupwith signup
Hyosyne coupon at Harris Teeter Pharmacy
$54.43
$ 51.43
$3 off with signupwith signup
Hyosyne coupon at Costco Pharmacy
$ 69.00
$88.00
$ 85.00
$3 off with signupwith signup
$127.00
$ 124.00
$3 off with signupwith signup
$127.00
$ 124.00
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/20/2025

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4.8 average rating
About Hyosyne

Hyosyne is a prescription smooth muscle relaxant in elixir and drops format that treats, as a secondary medication, the symptoms of a broad spectrum of disorders, including intestinal problems, stomach ulcers, kidney stones, gallstones, Parkinson's muscle rigidity, diarrhea, and intestinal spasms, among others. In drops format, Hyosyne is prescribed to treat infant colic. The active ingredient in Hyosyne, hyoscyamine, relaxes the smooth muscles that cause many of these symptoms. Hyosyne normally retails for $70.37, but SingleCare offers a free Hyosyne coupon that may significantly reduce Hyosyne's cost to $30.72.

Hyosyne Price History & Information

Price History for Hyosyne (Branded Generic) & Hyoscyamine Sulfate (Generic)

20 count, solution (quantity in ml), 0.125mg/ml

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Hyosyne (Branded Generic) & Hyoscyamine Sulfate (Generic)

20 count, solution (quantity in ml), 0.125mg/ml
PharmacyHyosyne Retail Price
CVS Pharmacy$91.00
Walmart$65.60
Walgreens$56.00
Kroger Pharmacy$53.40

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Hyosyne

Hyosyne is a prescription smooth muscle relaxant in elixir and drops format that treats, as a secondary medication, the symptoms of a broad spectrum of disorders, including intestinal problems, stomach ulcers, kidney stones, gallstones, Parkinson's muscle rigidity, diarrhea, and intestinal spasms, among others. In drops format, Hyosyne is prescribed to treat infant colic. The active ingredient in Hyosyne, hyoscyamine, relaxes the smooth muscles that cause many of these symptoms. Hyosyne normally retails for $70.37, but SingleCare offers a free Hyosyne coupon that may significantly reduce Hyosyne's cost to $30.72.

Hyosyne FAQs

How much does Hyosyne cost without insurance?

The retail price of Hyosyne without insurance averages $70.37. By taking your SingleCare discount card to a participating pharmacy, you pay only $30.72 for that same Hyosyne prescription.

How much does Hyosyne cost with insurance?

Copay costs of Hyosyne differ depending on your insurance plan. With SingleCare, Hyosyne costs only $30.72. You should consider asking your pharmacist to compare your Hyosyne insurance copay to your SingleCare Hyosyne coupon. You may do better with SingleCare.

Does Medicare cover Hyosyne and how much does it cost?

Medicare prescription drug programs do not cover Hyosyne. For patients without coverage, SingleCare offers discount coupons for Hyosyne which may reduce the cost of Hyosyne to $30.72.

Is there a generic of Hyosyne?

Hyosyne is a brand-name prescription drug with hyoscyamine in elixir and oral solution/drops formats. Generic hyoscyamine elixirs and drops are available from Method Pharmaceuticals.

What is Hyosyne?

Hyosyne is a generic prescription drug used along with other drugs to relieve spasms, pain, and excessive secretions by relaxing the smooth muscles responsible for those symptoms. It comes in elixir and drops formats for patients who are not able to swallow a pill, such as infants.

Hyosyne is prescribed to patients with problems that involve intestinal spasms, such as diarrhea, dysentery, and enterocolitis (inflammation of the inner lining of the intestines). Hyosyne relaxes the muscles in the intestines and reduces the frequency and strength of intestinal contractions. In drops format, Hyosyne can be used to relieve infant colic.

For patients with stomach ulcers, Hyosyne reduces the amount of acid the stomach produces by relaxing the muscles in the glands that produce acid.

Hyosyne relieves pain associated with kidney stones (renal colic) or gallstones (biliary colic). Hyosyne also helps patients who have lost bladder control., Hyosyne reduces the pressure in those organs. Finally, Hyosyne reduces secretions that cause runny nose and nasal irritation.

The active ingredient in Hyosyne, hyoscyamine, belongs to a class of drugs called anticholinergic drugs. These drugs interfere with a chemical, acetylcholine, that signals muscles to contract. Hyoscyamine relaxes the muscles found in the stomach, intestines, bladder, nasal glands, blood vessels, gall bladder, kidneys, and other areas in the body.

Hyosyne is taken as one or two tablets every 12 hours. Hyosyne is not approved by the FDA as safe and effective.

What are the side effects of Hyosyne?

Although not a complete list, common side effects of Hyosyne include dizziness, drowsiness, weakness, nausea, vomiting, bloating, decreased sweating, decreased urination, dry mouth, stomach pain, constipation, headache, insomnia, loss of taste, heart palpitations, blurred vision, reduced lactation, and impotence.

Allergic reactions to Hyosyne are rare but include rashes, hives, swelling, and trouble breathing. Discontinue use of Hyosyne if you experience an allergic reaction, severe abdominal pain, or chest pain.

Mental and mood changes are serious reactions and include anxiety, confusion, hallucinations, and unusual thoughts. Older patients are particularly vulnerable to mental and mood changes when taking Hyosyne.

Where are Hyosyne coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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