What is Kadcyla: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Kadcyla overview

BRAND NAMES:

  • Kadcyla

Generic Names:

  • Kadcyla

Uses:

  • Treats breast cancer.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Kadcyla used for?

Kadcyla is used to treat adults with human epidermal growth factor receptor 2 (HER-2) positive breast cancer that has spread. It is used after unsuccessful treatment with other anticancer medications. Kadcyla inhibits the growth of cancer cells. It is available as an injection.

What form(s) does Kadcyla come in

  • Injectable

What are common Kadcyla doses?

  • Solution Reconstituted 100MG

Common Kadcyla prescriptions

  • Kadcyla
    100mg solution reconstituted

  • Kadcyla
    160mg solution reconstituted

How to take Kadcyla

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be given slowly, so the needle will have to stay in place for at least 30 to 90 minutes.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be given slowly, so the needle will have to stay in place for at least 30 to 90 minutes.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

What to do if you miss a dose of Kadcyla

Kadcyla contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to trastuzumab or ado-trastuzumab, or if you are pregnant.

Kadcyla warnings

  • Injection routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Female patients should use an effective form of birth control during treatment and for 7 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 4 months after the last dose.

  • Do not breastfeed during treatment with this medicine and for 7 months after the last dose.

  • Tell your doctor if you have liver disease, kidney disease, heart disease, lung disease, heart failure, or bleeding problems.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • This medicine may cause the following problems:Liver problemsLung problemsNew or worsening heart failureInfusion reactionsIncreased risk of bleeding problemsBrain or nerve problems, including peripheral neuropathy

  • Injection routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual bleeding, bruising, or weakness, nosebleeds

Kadcyla interactions

  • Some medicines can affect how ado-trastuzumab works. Tell your doctor if you are using any of the following: Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazoleBlood thinner (including warfarin)

  • Tell your doctor if you are breastfeeding, or if you have liver disease, bleeding problems, heart disease, heart failure, or lung disease.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • This medicine may cause the following problems:Serious liver problemsLung problemsNew or worsening heart failureInfusion reactionsIncreased risk of bleeding problemsNerve problems, including peripheral neuropathy

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Kadcyla side effects

Serious Side Effects

  • Pain, redness, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet

  • Unusual bleeding, bruising, or weakness, nosebleeds

  • Dizziness, lightheadedness, or fainting

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, trouble breathing, cough, uneven heartbeat

  • Chills, fever, fast heartbeat, warmth or redness of the skin

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

Less Serious Side Effects

  • Headache

  • Constipation, mild nausea or vomiting

  • Tiredness

  • Muscle, joint, or bone pain