What is Kerendia: Uses, Warnings & Interactions

Take one tablet of Kerendia per day.

Your healthcare provider will advise you on the correct dose and how much medicine to take. Do not use more than directed or prescribed.

Swallow the tablet whole. If you’re unable to swallow a whole tablet, Kerendia can be crushed and mixed with water or applesauce immediately before taking it.

Always follow the instructions from your healthcare provider or those found on the prescription label.

Maintain consistency in the timing of your dose. Taking it at the same time every day may help improve its effectiveness.

Store the medication at room temperature, away from light and heat.

Do not stop taking Kerendia before talking with your healthcare provider.

Take a missed dose of Kerendia as soon as you remember. If it's almost time for your next scheduled dose, wait until then and take the regular dose.

Do not take two doses of Kerendia on the same day to make up for a missed dose.

Kerendia should be avoided in people experiencing adrenal insufficiency, as it can affect aldosterone-related issues. Adrenal insufficiency is a condition in which the adrenal glands do not adequately produce certain hormones, including cortisol and aldosterone. 

Kerendia should not be used in combination with medications known as strong CYP3A4 inhibitors. Examples of strong CYP3A4 inhibitors include ketoconazole, itraconazole, ritonavir, and clarithromycin. These medications can increase the levels of Kerendia in the blood, which can cause an increased risk of adverse effects.

The use of Kerendia may increase the risk of high potassium levels, especially if you have kidney problems or already elevated potassium. Symptoms of high potassium levels may include muscle weakness, fatigue, difficulty breathing, irregular heartbeat, and chest pain. 

Regular blood tests to check your potassium levels are necessary if you're taking Kerendia.

Consult your doctor before using any potassium supplements or salt substitutes that contain potassium.

Avoid medications that are strong or moderate CYP3A4 inhibitors or inducers; ask your doctor for alternatives that don't affect Kerendia.

Do not consume grapefruit or grapefruit juice, as they can significantly increase Kerendia's effects on your body.

Breastfeeding is not recommended during Kerendia treatment and for one day after the last dose.

Avoid strong CYP3A4 inhibitors: These can increase the levels of Kerendia in your body, leading to possible adverse effects. Use of these medications with Kerendia is not recommended. Examples include:

• Certain antifungals (such as ketoconazole)

• Some antibiotics (like clarithromycin)

• Some HIV protease inhibitors (such as ritonavir)

Be cautious with moderate and weak CYP3A4 inhibitors: These may also increase Kerendia levels, so close monitoring is required. Dosage adjustments for Kerendia might also be necessary. These drugs may include:

• Certain calcium channel blockers (such as diltiazem)

• Some antidepressants (like fluoxetine)

Avoid strong and moderate CYP3A4 inducers: These can decrease the levels of Kerendia, reducing its effectiveness. Examples include:

• Some antiepileptics (like phenytoin)

• Certain antibiotics (such as rifampin)

• Some herbal supplements like St. John's Wort

Monitor potassium levels while taking drugs that affect potassium: Certain medications or supplements can increase potassium, which may require more frequent monitoring. These can include:

• Potassium supplements

• ACE inhibitors

• ARBs (angiotensin receptor blockers)

• Some diuretics

Grapefruit juice is known to inhibit CYP3A4 and may also increase the blood levels of Kerendia. Avoiding grapefruit juice while on this medication is recommended.