Lybalvi Coupons & Prices

Lybalvi is a brand-name prescription drug used to treat schizophrenia and bipolar I disorder in adults. It is a combination drug that contains two active ingredients: olanzapine and samidorphan. The average retail price of Lybalvi is $2,281.65 for 30, 5-10mg tablets, but you may be able to use a free Lybalvi coupon from SingleCare’s discount program to reduce the price to $1,591.10 for 30, 5-10mg tablets.

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Lybalvi coupon at Walgreens Pharmacy
$1594.10
$ 1,591
$3 off with signupwith signup

Show this free card to your pharmacist.

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Lybalvi coupon at Kroger Pharmacy
$1615.95
$ 1,613
$3 off with signupwith signup

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Lybalvi coupon at Harris Teeter Pharmacy
$1615.95
$ 1,613
$3 off with signupwith signup
Lybalvi coupon at Food Lion Pharmacy
$ 1,688
Lybalvi coupon at CVS Pharmacy
$1693.09
$ 1,690
$3 off with signupwith signup
Lybalvi coupon at Publix Pharmacy
$1727.66
$ 1,725
$3 off with signupwith signup
$1735.05
$ 1,732
$3 off with signupwith signup
$1735.05
$ 1,732
$3 off with signupwith signup
$1744.43
$ 1,741
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/20/2025

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About Lybalvi

Lybalvi is a brand-name prescription drug used to treat schizophrenia and bipolar I disorder in adults. It is a combination drug that contains two active ingredients: olanzapine and samidorphan. The average retail price of Lybalvi is $2,281.65 for 30, 5-10mg tablets, but you may be able to use a free Lybalvi coupon from SingleCare’s discount program to reduce the price to $1,591.10 for 30, 5-10mg tablets.

Lybalvi Price History & Information

Price History for Lybalvi

30 count, tablet, 5-10mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Lybalvi

30 count, tablet, 5-10mg
PharmacyLybalvi Retail PriceLybalvi SingleCare Price
Walmart$1976.70$1735.20
Walgreens$1984.20$1591.80
Kroger Pharmacy$1976.40$1615.80

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Lybalvi

Lybalvi is a brand-name prescription drug used to treat schizophrenia and bipolar I disorder in adults. It is a combination drug that contains two active ingredients: olanzapine and samidorphan. The average retail price of Lybalvi is $2,281.65 for 30, 5-10mg tablets, but you may be able to use a free Lybalvi coupon from SingleCare’s discount program to reduce the price to $1,591.10 for 30, 5-10mg tablets.

Lybalvi FAQs

Medically reviewed by Ashley WongPharm. D.
Licensed Pharmacist

How much does Lybalvi cost without insurance?

The cost of Lybalvi depends on many factors, such as your dosage, quantity prescribed, and the pharmacy you purchase the medication from. The average retail price of Lybalvi without insurance is $2,281.65 for 30, 5-10mg tablets. 

How much does Lybalvi cost with insurance?

Copays vary depending on your health insurance plan. You can contact your pharmacist or insurance company to determine the exact cost of Lybalvi with insurance. The price may also depend on the quantity and dosage prescribed. Compare your cost with insurance to the cost with a SingleCare prescription discount, which could be as low as $1,591.10 for 30, 5-10mg tablets. You can choose to pay the retail price of Lybalvi with a SingleCare coupon rather than using your insurance coverage. 

Does Medicare cover Lybalvi and how much does it cost?

Lybalvi is covered by most Medicare plans. However, using Medicare coverage may not be the most affordable option. Ask your Medicare provider or pharmacist about the price of Lybalvi with Medicare. A SingleCare savings card may lower the cost to a more affordable price. For example, you could pay $1,591.10 for 30, 5-10mg tablets.

Is there a generic of Lybalvi?

No, a generic version of Lybalvi isn’t available at this time. 

What is Lybalvi?

Lybalvi is used to treat schizophrenia and bipolar I disorder in adults. It’s a combination medicine that contains olazanpine—an atypical antipsychotic—and samidorphan—an opioid antagonist. When used for bipolar disorder, Lybalvi may be taken alone or in combination with Lithobid (lithium) or Dekapote (valproic acid). 

What are the side effects of Lybalvi?

Common adverse effects of Lybalvi include:

  • Weight gain

  • Sleepiness

  • Dry mouth

  • Headache

  • Weakness

  • Constipation 

  • Dizziness

  • Back pain

Lybalvi may also cause serious side effects, such as:

  • Stroke in older adults

  • Neuroleptic malignant syndrome (a potentially life-threatening condition that can cause high fever, stiff muscles, and kidney problems)

  • Serious skin reactions

  • Metabolic changes, including high blood sugar levels, high cholesterol, and weight gain

  • Tardive dyskinesia (a syndrome characterized by involuntary movements)

  • Orthostatic hypotension (a drop in blood pressure upon standing up)

  • Low white blood cell count

  • Difficulty swallowing

  • Seizures

  • Serious allergic reactions

Ask a doctor about other possible side effects, warnings, precautions, and drug interactions. If you experience any signs or symptoms of an allergic reaction, such as severe rash, swelling, or trouble breathing, get help from a healthcare provider right away. 

Medically reviewed by Ashley WongPharm. D.
Licensed Pharmacist

Ashley Wong, Pharm.D., has worked for healthcare companies where she translated complex drug information into easy-to-understand language for patients. She also served as a Senior Medical Information Specialist at a medical communications company, where she delivered clinically accurate drug information to healthcare providers and patients and compiled adverse event reports in accordance with the FDA's reporting guidelines.

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Where are Lybalvi coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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