What is Memantine ER: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Memantine ER overview

BRAND NAMES:

  • Namenda XR Titration Pack, Namenda, Namenda Titration Pack, Namenda XR

Generic Names:

  • Memantine Hcl Er

Uses:

  • Treats dementia associated with Alzheimer disease.

Therapeutic Classes:

  • Central Nervous System Agent

Forms:

  • Long Acting Capsule, Liquid, Tablet

How it’s taken:

  • By mouth

What is Memantine ER used for?

What form(s) does Memantine ER come in

  • Long Acting Capsule

  • Liquid

  • Tablet

What are common Memantine ER doses?

  • Capsule Extended Release 24 Hour 7MG

  • Capsule Extended Release 24 Hour 14MG

  • Capsule Extended Release 24 Hour 21MG

  • Capsule Extended Release 24 Hour 28MG

Common Memantine ER prescriptions

  • Memantine HCl ER
    14mg capsule extended release 24 hour

  • Memantine HCl ER
    21mg capsule extended release 24 hour

  • Memantine HCl ER
    28mg capsule extended release 24 hour

  • Memantine HCl ER
    7mg capsule extended release 24 hour

How to take Memantine ER

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Most people need to wait at least one week between dose changes.

  • Oral routeYou may take this medicine with or without food.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.

  • Oral routeIf you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing.

  • For the liquid and extended-release capsule form: Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • For the liquid and extended-release capsule form: Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Oral routeYou may take this medicine with or without food.

  • Oral routeIf you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing.

  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Most people need to wait at least one week between dose changes.

What to do if you miss a dose of Memantine ER

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Memantine ER contraindications

  • You should not use this medicine if you have had an allergic reaction to memantine.

Memantine ER warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bladder problems or difficulty with urination, or epilepsy or seizures.

  • Check with your doctor right away if you get a urinary tract infection. This includes any infection in your bladder or kidneys. Your dose of this medicine might need to be changed while you have an infection.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Lightheadedness, dizziness, or fainting.

  • Seeing or hearing things that are not there.

  • Severe sleepiness, restlessness, or confusion.

  • Sudden or severe headache.

Memantine ER interactions

  • Make sure your doctor knows if you are also using amantadine (Symmetrel®), cimetidine (Tagamet®), ketamine (Ketalar®), metformin (Glucophage®), quinidine (Cardioquin®, Quinaglute®, Quinidex®), or ranitidine (Zantac®).

  • Tell your doctor if you are also using a diuretic or "water pill" (such as acetazolamide, hydrochlorothiazide [HCTZ], methazolamide, triamterene, Diamox®, Dyazide®, Dyrenium®, Maxzide®, or Neptazane®) or an antacid or laxative that contains sodium bicarbonate, baking soda, or bicarbonate of soda (such as Alka-Seltzer®).

  • Tell your doctor if you smoke or if you are using a stop-smoking aid that contains nicotine (such as Nicoderm®, Nicorette®, or Nicotrol®) or a cold or cough medicine that contains dextromethorphan (DayQuil®, NyQuil®, Robitussin® DM, or TheraFlu®).

Memantine ER side effects

Serious Side Effects

  • Sudden or severe headache.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate.

  • Chest pain.

  • Lightheadedness, dizziness, or fainting.

  • Seeing or hearing things that are not there.

  • Severe sleepiness, restlessness, or confusion.

Less Serious Side Effects

  • Feeling aggressive or depressed.

  • Weight gain.

  • Constipation, diarrhea, vomiting, or stomach pain.

  • Tiredness or weakness.

  • Back pain.

  • Mild headache.