What is Methotrexate (Anti-Rheumatic)? Uses, warnings & side effects

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you use this medicine only once a week and you miss a dose or forget to use your medicine, skip the missed dose and use your medicine as soon as possible. Return to your regular schedule the following week. Do not use extra medicine to make up for a missed dose.

You may store this medicine in the refrigerator or at room temperature. If stored at room temperature, throw it away after 60 days. Do not freeze or expose this medicine to high temperatures.

Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

If you use this medicine only once a week and you miss a dose or forget to use your medicine, skip the missed dose and use your medicine as soon as possible. Return to your regular schedule the following week. Do not use extra medicine to make up for a missed dose.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to methotrexate, or if you are pregnant or breastfeeding.

This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Women should use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Men should use an effective form of birth control during treatment and for at least 3 months after the last dose.

This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Tell your doctor if you have kidney disease, liver disease, bone marrow problems (including anemia), diabetes, a weak immune system, any type of infection, stomach ulcers, or a history of alcohol abuse.

This medicine may cause the following problems:Serious infections, which may be life-threateningKidney problemsStomach or bowel problems, including ulcer or perforationLiver problemsLung or breathing problemsSerious skin reactionsIncreased risk of other cancers

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Do not drink alcohol while you are using this medicine.

This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Tell your doctor if you have used methotrexate before for any reason.

Talk to your doctor before getting flu shots or other vaccines while you are receiving methotrexate. Vaccines may not work as well while you are using this medicine.

Some medicines can affect how methotrexate works. Tell your doctor if you are using any of the following:Azathioprine, cisplatin, nitrous oxide, phenytoin, probenecid, sulfasalazine, theophyllineMedicine to treat an infection (including penicillin, sulfamethoxazole, trimethoprim/sulfamethoxazole)NSAIDs or pain medicine (including aspirin, diclofenac, ibuprofen, naproxen)Other cancer medicines, including radiation treatmentRetinoid medicineSteroid medicineVitamin supplements containing folic acid

Make sure your doctor knows about any cancer treatments you are using, including cisplatin (Platinol®) or radiation.