What is Mucinex Sinus-Max: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Mucinex Sinus-Max overview

BRAND NAMES:

  • Alka-Seltzer Plus Day Severe Cold+Flu, Alka-Seltzer Plus Severe Cold+Flu, Alka-Seltzer Plus Severe Cough, Mucus & Congestion, Alka-Seltzer Plus Severe Sinus Cold & Cough, Cetafen Cough & Cold, Children's Mucinex Cold, Flu & Sore Throat, Children's Mucinex Cold & Sore Throat, Children's Mucinex Day/Night Freefrom, Children's Mucinex Multi-Symptom Cold Fever, Cold, Flu & Sore Throat, Cold & Cough Sinus Relief PE, Comtrex Deep Chest Cold, Daytime Head Congestion & Cold Relief, Decorel Forte Plus, Duraflu, Mucinex Sinus-Max Pressure & Pain, Mucinex Sinus-Max, Mucinex Sinus-Max Severe Congestion & Pain, Mucinex Sinus-Max Day/Night, Mucinex Sinus-Max Severe Congestion Relief, CCP, Daytime/Nighttime Sinus Relief, Good Neighbor Pharmacy Cold+Head Congestion Severe, Good Neighbor Pharmacy Sinus Relief, Good Neighbor Pharmacy Sinus Relief Day/Night, Good Neighbor Pharmacy Sinus Severe, Good Sense Mucus Relief Cold & Sinus, Good Sense Sinus Congestion & Pain Severe, Mucinex Fast-Max Cold & Sinus, Mucinex Fast-Max Congestion & Headache

Generic Names:

  • Mucinex Sinus-Max

Uses:

  • Treats fever, headache, sore throat, body aches, sneezing, runny and stuffy nose, and cough. May also help to loosen mucus in upper airways., Treats cold, flu, and allergy symptoms such as stuffy nose, fever, and mild aches, relieves sinus headaches, and helps loosen mucus.

Therapeutic Classes:

  • Analgesic/Antitussive/Decongestant/Expectorant Combination, Analgesic/Decongestant/Expectorant Combination

Forms:

  • Capsule, Tablet, Liquid Filled Capsule, Liquid, Chewable Tablet, Fizzy Tablet, Liquid, Long Acting Tablet, Tablet

How it’s taken:

  • By mouth, By mouth

What is Mucinex Sinus-Max used for?

What form(s) does Mucinex Sinus-Max come in

  • Capsule

  • Tablet

  • Liquid Filled Capsule

  • Liquid

  • Chewable Tablet

  • Fizzy Tablet

  • Liquid

  • Long Acting Tablet

  • Tablet

What are common Mucinex Sinus-Max doses?

  • Box 20 Tablets

  • Bottle 180ML of 10-650-400MG/20ML

How to take Mucinex Sinus-Max

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral routeIt is best to take this medicine with food or milk.

  • Swallow the tablet whole. Do not crush, break, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the tablet whole. Do not crush, break, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeIt is best to take this medicine with food or milk.

  • Avoid using the medicine at bedtime if it makes you restless.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Completely chew the chewable tablet before swallowing it.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • You may need to shake the liquid medicine container before opening it.

  • If the medicine is an effervescent tablet, carefully stir the tablet into at least 4 ounces (1/2 cup) of water. Drink all of it right away.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • You may need to shake the liquid medicine container before opening it.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Completely chew the chewable tablet before swallowing it.

  • If the medicine is an effervescent tablet, carefully stir the tablet into at least 4 ounces (1/2 cup) of water. Drink all of it right away.

  • Avoid using the medicine at bedtime if it makes you restless.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

What to do if you miss a dose of Mucinex Sinus-Max

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

Mucinex Sinus-Max contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to acetaminophen, guaifenesin, phenylephrine, or any other pain, cough, or cold medicines. Do not give any over-the-counter (OTC) cough and cold medicine to a child younger than 4 years.

  • You should not use this medicine if you have had an allergic reaction to acetaminophen (Tylenol®), or to any other ingredients in the medicine you are using. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects.

Mucinex Sinus-Max warnings

  • Children may be more sensitive to this medicine than adults, especially if they take too much of it. Always read the medicine label carefully so you give your child the right amount. Ask your pharmacist or doctor if you are not sure how much medicine to give your child.

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have heart disease, high blood pressure, diabetes, asthma, emphysema or other serious lung problems, an enlarged prostate gland that causes trouble passing urine, or thyroid problems.

  • Make sure your doctor knows if you drink alcohol often.

  • This medicine may make you nervous, dizzy, or unable to sleep. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have high blood pressure, diabetes, heart disease, an eye problem such as glaucoma, a thyroid, liver, or kidney problem, or an enlarged prostate.

  • Tell your doctor if your symptoms get worse after 2 or 3 days of treatment, or if they do not improve after 7 days.

  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.

  • This medicine may make you dizzy or drowsy. Do not drive or use machines if you are not alert.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Seizures or tremors

  • Severe headache

  • Trouble breathing

  • Unusual bleeding, bruising, or weakness

Mucinex Sinus-Max interactions

  • Do not take this medicine if you have taken an MAO inhibitor (MAOI) within the past 14 days.

  • Some medicines and foods can affect how this medicine works. Tell your doctor if you are taking any of the following: Digoxin, guanethidine, indomethacin, mecamylamine, methyldopa, reserpineBeta-blockers (such as atenolol, labetalol, metoprolol), medicine that contains acetaminophen, veratrum alkaloids

  • Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver, and alcohol can increase this risk. If you regularly drink 3 or more alcoholic drinks every day, do not take any medicines that contain acetaminophen without asking your doctor. A drink of alcohol is 12 ounces of beer, 4 ounces of wine, or 1 ounce of liquor.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • You should not use this medicine if you are using certain medicines for depression called MAO inhibitors, such as Nardil®, Marplan®, Eldepryl®, or Parnate®.

  • Do not use other medicines that contain acetaminophen, a cough suppressant, a decongestant, or an expectorant while taking this medicine. You may be getting more than a safe amount of these medicines.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver and alcohol can increase this risk. If you often drink three or more alcoholic drinks every day, do not take any medicines that contain acetaminophen without asking your doctor.

Mucinex Sinus-Max side effects

Serious Side Effects

  • Lightheadedness, dizziness, or fainting

  • Severe headache

  • Trouble breathing

  • Painful urination

  • Seizures or tremors

  • Unusual bleeding, bruising, or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Confusion, depression, fear, or anxiety

  • Fast, pounding, or uneven heartbeat

  • Hearing or seeing things that are not really there

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Fever that lasts for a long time or a fever that does not go away.

  • Trouble passing urine.

Less Serious Side Effects

  • Redness of your throat or swelling around your throat.

  • Trouble passing urine.

  • Cough that lasts for a long time or a cough that does not go away.

  • New symptoms.

  • Rash or pale skin

  • Trouble sleeping

  • Dry mouth or heavy sweating

  • Nausea or vomiting

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