Myrbetriq dosage, forms, and strengths
Myrbetriq is a brand-name prescription drug used to treat overactive bladder in adults and pediatric neurogenic detrusor overactivity (NDO) in children. Mirabegron, the active ingredient in Myrbetriq, relaxes the muscle that is responsible for squeezing urine out of the bladder. This allows the bladder to fill with more urine, reducing the symptoms of an overactive bladder. Myrbetriq is taken once per day as a tablet or oral suspension with or without food. It is sometimes used in combination with VESIcare (solifenacin succinate), a drug that also relaxes bladder muscles. Both Myrbetriq and solifenacin must be taken once per day at the same time.
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Myrbetriq forms and strengths
Myrbetriq comes in two forms: extended-release tablets and extended-release granules. The granules are mixed to form a liquid suspension when the prescription is picked up from a pharmacy.
Tablets: 25 milligrams (mg), 50 mg
Oral suspension: 8 mg/ml
Myrbetriq dosage for adults
The U.S. Food and Drug Administration (FDA) has approved Myrbetriq to treat overactive bladder in adults either as monotherapy (one drug only) or as part of combination therapy with VESIcare (solifenacin). The starting dose is 25 mg and may be increased after four to eight weeks.
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Myrbetriq dosage chart |
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|---|---|---|---|
| Indication | Starting dosage | Standard dosage | Maximum dosage |
| Overactive bladder monotherapy | 25 mg dose taken once per day | 25–50 mg dose taken once per day | 50 mg per day |
| Overactive bladder combination therapy with solifenacin | 25 mg dose taken once per day | 25–50 mg dose taken once per day | 50 mg per day |
Source: Epocrates
Myrbetriq dosage for overactive bladder (OAB)
People with an overactive bladder experience frequent and urgent needs to urinate as well as urine leakage. When the bladder fills with urine, the muscles stretch and then tighten, creating an urgent need to urinate. With an overactive bladder, the muscles in the bladder start squeezing too early, before the bladder has completely filled.
Myrbetriq is a beta-3 adrenergic agonist. It attaches to a protein on the cells of the bladder muscles and lets the bladder fill with more urine before the muscles contract. By relaxing bladder muscles, Myrbetriq decreases the symptoms of OAB such as urinating too often, too urgently, or leaking urine.
Standard dosage for overactive bladder in adults: 25–50 mg once daily
Maximum dosage for overactive bladder in adults: 50 mg once daily
Myrbetriq dosage for children
Myrbetriq is FDA-approved to treat pediatric neurogenic detrusor overactivity (NDO) in children 3 years of age and older. The detrusor muscle is a muscle in the bladder wall that squeezes urine out of the bladder. NDO is typically caused by conditions that cause intermittent contraction of this muscle before the bladder has filled. As with adult overactive bladder, Myrbetriq works by relaxing the detrusor muscle so the bladder can fill with more urine.
Children weighing less than 35 kilograms (kg) are given oral suspension Myrbetriq. Children who weigh 35 kg or more can take either Myrbetriq tablets or oral suspension. Dosing for pediatric patients is based on body weight. The recommended starting dose is always the lowest dose in the dosing range for that weight.
Myrbetriq dosage by weight |
||
|---|---|---|
| Weight | Recommended dosage (tablet) | Recommended dosage (liquid) |
| 11–21 kg (>3 years) | -- | 3–6 mL (24–48 mg) taken once daily |
| 22–34 kg (>3 years) | -- | 4–8 mL (32–64 mg) taken once daily |
| >35 kg | 25–50 mg tablet taken once daily | 6–10 mL (48–80 mg) taken once daily |
One kilogram = 2.2 pounds
Myrbetriq dosage restrictions
Like all prescription drugs, Myrbetriq is not right for everyone. People with certain health conditions including severe, uncontrolled high blood pressure (hypertension), allergic reactions to mirabegron or the other ingredients in this medication, or advanced kidney disease should not take Myrbetriq
People with bladder obstruction should be careful when taking Myrbetriq because they are at a higher risk of urinary retention.
People with moderate kidney problems and liver problems will need to take a lower dose. This is because Myrbetriq is broken down by the liver and removed from the body by the kidneys.
How to take Myrbetriq
Each dose of Myrbetriq is taken once per day. If Myrbetriq is prescribed with solifenacin, both tablets should be taken once per day at the same time.
Take Myrbetriq as directed. Do not take more or less medication without talking to your healthcare provider.This medicine comes with a medication guide. If the medication guide is missing, ask a pharmacist for a copy.
Myrbetriq and solifenacin tablets can be taken with or without food
.Children should take Myrbetriq with food.
Tablets
Take only one Myrbetriq tablet one time each day.
If Myrbetriq is prescribed with solifenacin, take both the Myrbetriq tablet and solifenacin tablet at the same time.
Swallow the Myrbetriq tablet whole with a glass of water. Do not crush, break, or chew the tablet.
Store this medicine at room temperature (68°F to 77°F) in a closed container.
Oral suspension
When ready to administer a dose, shake the bottle vigorously for one minute.
After shaking the bottle, allow it to sit for one to two minutes to allow the foam to settle.
Use the dosing device provided with the medicine to measure out the dose. Do not use a spoon. If the dosing device is missing, a pharmacist can provide a new one.
Give the dose with food within one hour of shaking the bottle.
Wash and rinse the dosing device after each use and let it air dry.
Store this medicine at room temperature (68°F to 77°F) in a closed bottle.
The oral suspension must be used within 28 days after being prepared by the pharmacist.
Myrbetriq dosage FAQs
How long does it take Myrbetriq to work?
It typically takes four to eight weeks of daily dosing for symptoms to improve. Symptoms may continue to improve for up to 12 weeks after starting Myrbetriq.
How long does Myrbetriq stay in your system?
With a terminal half-life of 50 hours, it takes about 10 days for Myrbetriq to be fully eliminated from the body.
What happens if I miss a dose of Myrbetriq?
Take a missed dose as soon as you remember. However, if more than 12 hours have passed since the missed dose, skip it and take the next scheduled dose at its usual time.
How long can you take Myrbetriq?
Myrbetriq is typically prescribed as a long-term treatment.
How do I stop taking Myrbetriq?
Myrbetriq can be safely stopped at any time without causing withdrawal symptoms.
Myrbetriq may need to be stopped for any number of reasons. It may not improve symptoms for some people. Others may need to stop Myrbetriq because of an allergic reaction or serious side effects like very high blood pressure, hallucinations, or not being able to urinate. Some people taking Myrbetriq may not be able to live with more common side effects like urinary tract infections (UTIs), dry mouth, headache, fast heart rate (tachycardia), stuffy nose and sore throat (nasopharyngitis), or constipation.
If an adult or child with bladder problems cannot take Myrbetriq, there are other kinds of medication that can be used.
What is the maximum dosage for Myrbetriq?
The maximum dose for Myrbetriq tablets is 50 mg per day, but the maximum dose for Myrbetriq oral suspension is 80 mg per day (10 mL) depending on the child’s body weight.
Can you overdose on Myrbetriq?
A Myrbetriq overdose can cause high blood pressure and a fast heart rate. If too much Myrbetriq has been taken, call a poison helpline or get immediate medical attention.
What interacts with Myrbetriq?
Drug interactions may cause problems in people taking Myrbetriq. Tell your healthcare provider about all prescription drugs, over-the-counter drugs, vitamins, and herbal supplements you are taking, especially thioridazine, flecainide, Lanoxin (digoxin), Rythmol (propafenone), isocarboxazid, eliglustat, phenelzine, or tranylcypromine. .
Myrbetriq interferes with a liver enzyme called CYP2D6 that breaks down other drugs, increasing the risk of adverse reactions from those drugs. Tell your healthcare provider about all medications you take because some doses may need to be adjusted.
What happens when you mix Myrbetriq and alcohol?
The FDA and Astellas Pharma, the manufacturer of Myrbetriq, do not advise or warn people not to drink when taking Myrbetriq. Still, the healthcare professional prescribing Myrbetriq might advise against drinking for other reasons. Follow any instructions given by the prescribing healthcare provider regarding food and drink when taking this medication.
Is it safe to take Myrbetriq during pregnancy?
There are no human studies concerning the use of Myrbetriq during pregnancy, but there is no evidence that Myrbetriq causes birth defects or miscarriage based on animal studies. Women who become pregnant while taking Myrbetriq should consult with their healthcare provider.
It is believed that the amount of mirabegron in breast milk is low but talk to a healthcare provider about safer medications to use while breastfeeding.
Related resources for Myrbetriq dosages:
Adrenergic drugs
, StatPearlsMirabegron
, Drugs and Lactation DatabaseMirabegron compound information
, U.S. National Library of MedicineMyrbetriq
, EpocratesMyrbetriq drug summary
, Prescriber’s Digital ReferenceMyrbetriq prescribing information
, U.S. National Library of MedicineMyrbetriq HCP
, Astellas PharmaMyrbetriq
, Astellas PharmaPharmacotherapy for pediatric neurogenic detrusor overactivity
, Pediatric Drugs
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