What is Nebivolol: Uses, Warnings & Interactions

Follow all the prescriber’s directions. Doses will change during treatment to find the most effective dose. 

Please read the Patient Information sheet that comes with the medicine.

Take only one dose daily.

Take nebivolol tablets with or without food. 

Swallow the tablet whole with a drink of water. 

Please follow any diet recommended by the health care team.

Do not stop taking nebivolol doses until talking to the prescriber.

Store nebivolol tablets at room temperature

If a dose is missed, take it as soon as you remember.

If it’s nearly time for the next dose, skip the missed dose.

Take the next dose as scheduled.

Do not take two doses to make up for a missed dose.

This medicine is not right for everyone. 

Do not use it if you have had an allergic reaction to nebivolol or have been diagnosed with:

• Severe liver impairment

• A very slow heart rate (severe bradycardia)

• Heart failure that requires hospitalization or medicines to maintain adequate blood flow (decompensated heart failure)

• Moderate or severe heart block

• A heart rhythm problem called sick sinus syndrome (unless a permanent pacemaker is in place)

Nebivolol is contraindicated in anyone with cardiogenic shock, an immediately life-threatening condition in which the heart no longer functions well enough to maintain life.

Tell any doctor or other healthcare provider who treats you that you are using this medicine. You may need to stop taking nebivolol before major surgery or certain medical tests.

The prescriber will need regular office visits and lab tests to adjust doses and monitor for side effects. Keep all appointments.

Tell your doctor if you are pregnant, breastfeeding, or have:

• Asthma or other obstructive lung diseases, such as bronchitis or emphysema

• Heart failure

• Heart rhythm abnormalities

• Slow heart rate

• Blood flow problems in your legs or feet

• Liver problems

• Kidney problems

• Diabetes

• Thyroid disorders

• Adrenal gland cancer (pheochromocytoma)

• A history of drug allergies or severe allergic reactions (anaphylactic reactions)

Nebivolol masks the symptoms of low blood sugar (hypoglycemia), so it should be used cautiously in people being treated for diabetes or people who are fasting. Ask the prescriber about the signs of low blood sugar that are not masked by nebivolol.

This medicine may cause impairment. Before driving, operating machinery, or doing anything else that requires alertness, you should know how this medicine affects you. 

Do not stop taking nebivolol suddenly. The dose may need to be gradually reduced to prevent serious problems like chest pain or a heart attack.

Nebivolol has some significant drug interactions, so the prescriber should know about all the medications you’re taking, particularly: 

• Other beta blockers

• Blood pressure drugs called calcium channel blockers

• Drugs that treat heart rhythm problems, including digoxin, quinidine, and propafenone

• The blood pressure drugs guanethidine, clonidine, or reserpine

• Drugs that treat depression, psychosis, anxiety, or similar mental health issues

• Paxlovid, rifampin, ritonavir

Do not drink alcohol while using nebivolol.

Tell other healthcare providers you are using this medicine before they prescribe new medications or use general anesthetics.