What is Metoprolol Tartrate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Metoprolol tartrate is the immediate-release version of metoprolol, a commonly prescribed cardioselective beta blocker. Used for blood pressure or heart problems, metoprolol tartrate works by slowing the heart and reducing the force of its contractions. This reduces blood pressure and relieves the stress on the heart muscle. Doses are taken twice daily. Healthcare professionals have the option of prescribing extended-release metoprolol succinate so that only one dose per day is required.

Metoprolol Tartrate overview

BRAND NAMES:

  • Lopressor

Generic Names:

  • Metoprolol tartrate

Uses:

  • Treats high blood pressure and angina (chest pain). Metoprolol tartrate injections and tablets also help reduce the risk of death after a heart attack.

Therapeutic Classes:

  • Beta blocker, antianginal, antiarrhythmic, antihypertensive, cardiovascular agent

Forms:

  • Tablet, injectable

How it’s taken:

  • By mouth, intravenous injection

What is Metoprolol Tartrate used for?

Healthcare providers use metoprolol tartrate to treat high blood pressure or chest pain (angina). Metoprolol is also an emergency and maintenance treatment that reduces the risk of death after a heart attack. Healthcare providers sometimes prescribe it off-label to treat heart rhythm problems (atrial fibrillation or fast heartbeats), relieve tremors, or prevent migraine headaches.

What form(s) does Metoprolol Tartrate come in

  • Tablet 

    • 25 mg

    • 37.5 mg

    • 50 mg

    • 75 mg

    • 100 mg

  • Vial 

    • 5 mg/5mL

What are common Metoprolol Tartrate doses?

  • For hypertension in adults: 100–450 mg daily taken by mouth in two divided doses

  • For chronic stable angina in adults: 100–400 mg taken orally in two divided doses

  • For heart attack: Three 5 mg intravenous injections given two minutes apart, followed by 25–50 mg taken by mouth every six hours for 48 hours, followed by 100 mg taken by mouth twice daily for three months to three years 

Find more information about metoprolol dosage, forms, and strengths here.

Common Metoprolol Tartrate prescriptions

  • Metoprolol Tartrate
    5ml of 5mg/5ml ampule

  • Metoprolol Tartrate
    30 tablets bottle

  • Metoprolol Tartrate
    100mg tablet

  • Metoprolol Tartrate
    25mg tablet

  • Metoprolol Tartrate
    37.5mg tablet

  • Metoprolol Tartrate
    50mg tablet

  • Metoprolol Tartrate
    75mg tablet

  • Metoprolol Tartrate
    5ml of 5mg/5ml vial

How to take Metoprolol Tartrate

  • Take your medicine as directed. Your dose may need to be changed several times to find the most effective dose.

  • Take this medicine with a meal or right after a meal. 

  • Always take it at the same time of day in the same way (either with a meal or on an empty stomach). 

  • Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

  • The tablet is scored to allow it to be divided into two doses. If the doctor asks you to take half a tablet, have a healthcare professional, such as a pharmacist, demonstrate how to do this.

  • Store metoprolol tartrate tablets at room temperature in a closed, light-resistant container. Keep the tablets protected from moisture.

What to do if you miss a dose of Metoprolol Tartrate

  • If a dose is missed, skip it. 

  • Take the next dose as scheduled. 

  • Do not take extra tablets to make up for a missed dose.

Metoprolol Tartrate contraindications

  • This medicine is not right for everyone. 

  • Healthcare providers never give metoprolol to anyone who has had an allergic reaction to metoprolol or has any of the following cardiovascular conditions:

    • Severely slow heart rate

    • Extremely low blood pressure

    • Heart block

    • Sick sinus syndrome (without a permanent pacemaker)

    • Sudden worsening of heart failure

  • Healthcare providers never use metoprolol tartrate when the heart is no longer functioning well enough to maintain life (cardiogenic shock).

Metoprolol Tartrate warnings

  • Tell any doctor or other healthcare provider who treats you that you are using this medicine. You may need to stop using this medicine several days before major surgery or certain medical tests.

  • The prescriber will need regular office visits and lab tests to monitor the effects of this medicine and make dose adjustments. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding.

  • Tell your doctor if you have:

    • Heart failure

    • Heart rhythm abnormalities

    • Slow heart rate

    • Circulation problems in the hands, arms, legs, or feet

    • Lung diseases such as asthma, bronchitis, or emphysema

    • Kidney disease

    • Liver disease

    • Diabetes

    • Thyroid disorders

    • Adrenal gland cancer 

  • This medicine may worsen the symptoms of heart failure or lower blood pressure too much, especially when metoprolol is first started.

  • Metoprolol can make it hard to spot low blood sugar (hypoglycemia) because it corrects many of the symptoms of low blood sugar.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that requires alertness until you know how this medicine affects you.

  • Do not stop using metoprolol suddenly. Talk to the prescriber first. The dose may need to be gradually reduced to prevent serious problems like chest pain or heart attack.

Metoprolol Tartrate interactions

  • To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use, particularly:

    • Heart rhythm medications, including digoxin, quinidine, and propafenone

    • Calcium channel blockers

    • Migraine treatments called ergots

    • HIV/AIDS drugs

    • Drugs that treat depression, psychosis, anxiety, or similar other mental health issues

    • MAO inhibitors (MAOIs)

    • The blood pressure drugs clonidine or reserpine

    • The blood thinner dipyridamole

  • Do not drink alcohol while being treated with metoprolol.

  • Tell other healthcare providers you are using this medicine before they prescribe new medications.

Find more detailed information about metoprolol interactions to avoid here.

Metoprolol Tartrate side effects

Serious side effects

Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Slow heartbeat

  • Palpitations

  • Worsening chest pain or new chest pain

  • Swelling in your hands, ankles, or feet, trouble breathing

  • Lightheadedness, dizziness, fainting

  • Trouble breathing, shortness of breath, asthma-like symptoms

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less serious side effects

  • Low blood pressure

  • Drowsiness

  • Dizziness

  • Fatigue

Find more detailed information about metoprolol side effects here.

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