Neffy Coupons & Prices

Neffy is a nasal epinephrine spray used for the emergency treatment of type I allergic reactions. Neffy, which contains the active ingredient epinephrine, was approved by the U.S. Food and Drug Administration (FDA) in 2024. It is the first epinephrine product that is a needle-free device and the only one to date. The average retail price of Neffy is $949.70 per 1, 2 solution box, but you can pay just $695.09 for 1, 2 solution box of Neffy with a SingleCare prescription drug discount card.

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Neffy coupon at Walgreens Pharmacy
$698.09
$ 695.09
$3 off with signupwith signup

Show this free card to your pharmacist.

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Neffy coupon at Kroger Pharmacy
$699.38
$ 696.38
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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Neffy coupon at Harris Teeter Pharmacy
$699.38
$ 696.38
$3 off with signupwith signup
Neffy coupon at Food Lion Pharmacy
$ 732.20
Neffy coupon at CVS Pharmacy
$743.44
$ 740.44
$3 off with signupwith signup
Neffy coupon at Publix Pharmacy
$749.24
$ 746.24
$3 off with signupwith signup
$751.01
$ 748.01
$3 off with signupwith signup
$751.01
$ 748.01
$3 off with signupwith signup
$754.76
$ 751.76
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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4.8 average rating
About Neffy

Neffy is a nasal epinephrine spray used for the emergency treatment of type I allergic reactions. Neffy, which contains the active ingredient epinephrine, was approved by the U.S. Food and Drug Administration (FDA) in 2024. It is the first epinephrine product that is a needle-free device and the only one to date. The average retail price of Neffy is $949.70 per 1, 2 solution box, but you can pay just $695.09 for 1, 2 solution box of Neffy with a SingleCare prescription drug discount card.

Neffy Price History & Information

Price History for Neffy

1 count, box, 2 solution

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Neffy

1 count, box, 2 solution
PharmacyNeffy Retail PriceNeffy SingleCare Price
CVS Pharmacy$838.98$745.94
Walmart$852.00$751.02
Walgreens$853.10$754.40
Kroger Pharmacy$851.98$699.38
Albertsons Pharmacy$784.70$751.24

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Neffy

Neffy is a nasal epinephrine spray used for the emergency treatment of type I allergic reactions. Neffy, which contains the active ingredient epinephrine, was approved by the U.S. Food and Drug Administration (FDA) in 2024. It is the first epinephrine product that is a needle-free device and the only one to date. The average retail price of Neffy is $949.70 per 1, 2 solution box, but you can pay just $695.09 for 1, 2 solution box of Neffy with a SingleCare prescription drug discount card.

Neffy FAQs

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

How much does Neffy cost without insurance?

The standard out-of-pocket cost of Neffy without health insurance is $949.70 per 1, 2 solution box though you can save using a SingleCare Neffy coupon to pay only $695.09 for 1, 2 solution box of Neffy. If you don’t have access to an insurance plan, you can still use SingleCare for free Neffy savings. For eligible patients without insurance coverage or those with high out-of-pocket costs, ARS Pharma offers Neffy at a discounted cash price.

How much does Neffy cost with insurance?

Each insurance formulary is different and may or may not cover Neffy. The cost of Neffy with insurance coverage varies based on insurance plans. Check with your insurance provider for specific drug coverage and copay details. People with insurance that provides coverage for Neffy can check the manufacturer's website for more information about the copay program, which can help eligible patients save money on this medicine. Check the manufacturer's website for more information and eligibility requirements.

If your insurance does not cover Neffy, you can use SingleCare to get discounts on Neffy at your participating pharmacy. Additionally, you can also use SingleCare coupons if you have Medicare or Medicaid. If Medicare or Medicaid don’t cover your Neffy prescription, you can use SingleCare instead. Go to the SingleCare website or app to compare the lowest price of Neffy with SingleCare versus your copay with insurance or Medicare. You can also check the manufacturer's website for other savings options or information on financial assistance. 

Does Medicare cover Neffy, and how much does it cost?

Neffy costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Neffy and how much the copay or coinsurance is. If Neffy is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full price of $949.70 for 1, 2 solution box. In that case, using a SingleCare coupon for Neffy could save you more money than Medicare. Our lowest price for Neffy is currently $695.09 for 1, 2 solution box.

Is there a generic of Neffy?

Neffy is a brand name drug made by Ars Pharmaceuticals Operations. There is no generic version of Neffy at this time. Use a SingleCare prescription drug discount card to pay $695.09 for 1, 2 solution box.

What is Neffy? 

Neffy is a prescription nasal spray that contains the active ingredient epinephrine. It is the first and only needle-free epinephrine treatment approved by the FDA for severe allergic reactions, which may be especially helpful for those with a fear of needle-based injections. Neffy, made by the company ARS Pharmaceuticals, is classified as an alpha and beta-adrenergic receptor agonist. It is FDA-approved to treat type I allergic reactions, including the treatment of anaphylaxis, in adults and children weighing 66 pounds or more. 

Type I allergic reactions, also called immediate hypersensitivity reactions, happen quickly, usually within minutes after coming into contact with an allergen. This reaction is caused by the release of chemicals like histamine from cells in the body, leading to symptoms such as itching, swelling, and hives. Treatment typically includes antihistamines, corticosteroids, and, in severe cases, epinephrine.

Each Neffy has one dose of medicine for a one-time use. Do not test spray the device before using. Administer one spray of Neffy into one nostril, aiming straight up, and press the plunger firmly to activate. Do not sniff during or after using Neffy. If any liquid drips from your nose, you might not get the full dose. If symptoms worsen or do not improve, a second dose can be administered in the same nostril, but with a new nasal spray, 5 minutes later. Patients who are prescribed Neffy should always carry two Neffy nasal sprays with them.

Before giving you a prescription for Neffy, your healthcare provider will talk to you about when to get emergency help. If you have an allergic emergency, you should use Neffy right away. You should get emergency medical help for further treatment if needed after using Neffy. If you are not sure whether you need emergency medical help, it is best to err on the side of caution and call 911 for emergency medical assistance. 

If you have certain medical conditions or take specific medicines, using Neffy might make your condition worse or cause more severe or longer-lasting side effects. Before using Neffy, tell your healthcare provider about all of your medical conditions, including if you are pregnant or breastfeeding. Be sure to mention if you have any problems with the nose, including nasal polyps or past nasal surgery. 

Store Neffy at room temperature. Do not freeze, as freezing will prevent the device from working. Replace Neffy before the expiration date.

What are the side effects of Neffy?

The most common side effects of Neffy are:

  • Throat irritation

  • Nasal tingling, itching, or discomfort

  • Runny nose

  • Stuffy nose (nasal congestion)

  • Headache

  • Excitement, nervousness, or anxiety

  • Tingling sensation

  • Fatigue or shaking

  • Sneezing

  • Abdominal pain, nausea, or vomiting

  • Dizziness

  • Gum pain or numbness in the mouth

What other drugs will affect Neffy? 

Before using Neffy, tell your doctor about all the medicines you take, including prescription and OTC drugs, vitamins, and supplements. Be sure to mention if you are taking any of the following medicines.

  • Any nasal spray (Neffy may change the nasal mucosa for up to 2 weeks after use, which can increase how much other nasal products, including Neffy, are absorbed. This could raise the risk of side effects from these products.)

  • Diuretics (water pills)

  • Certain antidepressants (tricyclic antidepressants or MAOIs)

  • Medicines for heart disease or heart rhythm, including beta blockers such as propranolol

  • Medicines for Parkinson’s disease

  • Ergots for migraine

  • Thyroid medications, such as levothyroxine

  • Antihistamine allergy medications like Benadryl (diphenhydramine)

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.

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Where are Neffy coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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