Opzelura is a prescription medication used to treat atopic dermatitis (eczema) and vitiligo. It is a brand-name topical medication containing ruxolitinib. Opzelura works as a Janus kinase inhibitor, targeting specific proteins to reduce inflammation and relieve symptoms. There is currently no generic version available. On average, Opzelura retails at $2,836.3 for 1, 60gm of 1.5% tube of cream. However, with a SingleCare Opzelura coupon, you may be able to save, reducing the price to just $1,835.86 for 1, 60gm of 1.5% tube of cream at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/18/2025
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Opzelura is a prescription medication used to treat atopic dermatitis (eczema) and vitiligo. It is a brand-name topical medication containing ruxolitinib. Opzelura works as a Janus kinase inhibitor, targeting specific proteins to reduce inflammation and relieve symptoms. There is currently no generic version available. On average, Opzelura retails at $2,836.3 for 1, 60gm of 1.5% tube of cream. However, with a SingleCare Opzelura coupon, you may be able to save, reducing the price to just $1,835.86 for 1, 60gm of 1.5% tube of cream at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Opzelura Retail Price | Opzelura SingleCare Price |
|---|---|---|
| CVS Pharmacy | $2466.00 | $1906.80 |
| Walmart | $2512.80 | $2325.00 |
| Walgreens | $2514.00 | $2032.20 |
| Kroger Pharmacy | $2512.80 | $1864.80 |
| Albertsons Pharmacy | $2311.80 | $2007.00 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Opzelura is a prescription medication used to treat atopic dermatitis (eczema) and vitiligo. It is a brand-name topical medication containing ruxolitinib. Opzelura works as a Janus kinase inhibitor, targeting specific proteins to reduce inflammation and relieve symptoms. There is currently no generic version available. On average, Opzelura retails at $2,836.3 for 1, 60gm of 1.5% tube of cream. However, with a SingleCare Opzelura coupon, you may be able to save, reducing the price to just $1,835.86 for 1, 60gm of 1.5% tube of cream at participating pharmacies.
If you don’t have insurance, the average cost of Opzelura is $2,836.3 for 1, 60gm of 1.5% tube of cream. Prices may vary based on location and pharmacy. Fortunately, SingleCare provides a solution for cash-paying patients and those without commercial prescription insurance. With a SingleCare Opzelura coupon, the cost may be lowered to just $1,835.86 for 1, 60gm of 1.5% tube of cream.
Some insurance plans may help cover Opzelura, including commercial insurance and government-funded prescription insurance programs. While many health plans may help cover Opzelura, copays and coinsurance may apply. It's recommended to consult your insurance plan or pharmacist for specific cost details. Sometimes, SingleCare coupons may offer more savings than your insurance plan, so it's worth comparing prices.
Medicare coverage for Opzelura depends on the specific Medicare Part D or Medicare Advantage plan. Some patients may find that a SingleCare card offers lower prices than Medicare, with the cost potentially dropping to $1,835.86 for 1, 60gm of 1.5% tube of cream. Always compare prices with your local pharmacy to ensure you're getting the best deal.
Currently, there are no generic alternatives for Opzelura. The patent for Opzelura is expected to expire in 2027, when a generic version may become available on the market. Consult a healthcare provider to determine the most cost-effective treatment options available.
Opzelura is a topical prescription therapy used to treat atopic dermatitis and vitiligo. It’s approved for short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis and nonsegmental vitiligo.
This drug is part of a class of medicines known as Janus kinase (JAK) inhibitors, which help reduce inflammation in affected areas of the skin. It interferes with the activity of certain enzymes in the immune system that are involved in the inflammatory process. By doing so, it helps relieve itching and redness in people with atopic dermatitis and restores pigment in those with vitiligo.
Opzelura is available as a 1.5% topical cream. The typical dosage is a thin layer applied to affected areas twice daily. The maximum dosage is one 60-gram tube per week or one 100-gram tube once every two weeks. It should not be applied to the eyes, mouth, or vagina. Consult a healthcare provider for the appropriate dosage and administration.
Common side effects of Opzelura may include:
Common cold symptoms
Diarrhea
Acne
Headaches
Application site reactions (e.g., itching, redness, or swelling at the area of application)
More serious adverse effects are possible, such as serious infections, an increased risk of cancer or immune system issues, blood clots (deep vein thrombosis or pulmonary embolism), and an increased risk of cardiovascular events, such as heart attack and stroke. Seek medical advice before starting treatment and consult a healthcare provider about potential side effects and precautions.
No, Opzelura is not available over the counter. It is a prescription medication that requires a consultation from a doctor or healthcare provider.
In most cases, a 60-gram tube should last no longer than one week, and a 100-gram tube should last no longer than two weeks. The duration a tube of Opzelura lasts depends on the frequency of use, where it’s applied, and what it’s used for, based on the prescription. Always follow the prescribed dosage and instructions from your doctor or healthcare provider.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
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© 2025 SingleCare Administrators. All rights reserved