Orphenadrine citrate ER is a prescription muscle relaxant that relieves muscle pain. Patients take a single tablet without regard to food twice daily. As with other muscle relaxants, side effects are common, particularly impairment that interferes with driving or other activities.
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Orphenadrine ER overview
BRAND NAMES:
No brand-name version
Generic Names:
Orphenadrine citrate ER
Uses:
Used with rest, physical therapy, and other measures to relieve muscle pain and discomfort
Therapeutic Classes:
Central-acting skeletal muscle relaxant, anticholinergic
Forms:
Extended-release tablet
How it’s taken:
By mouth
What is Orphenadrine ER used for?
Orphenadrine citrate ER is a muscle relaxant that treats muscle pain and discomfort caused by certain health problems or injuries, such as sprains.
What form(s) does Orphenadrine ER come in
Tablet
100 mg
What are common Orphenadrine ER doses?
For muscle pain: 100 mg tablet taken twice daily, once in the morning and once at night
Common Orphenadrine ER prescriptions
Orphenadrine Citrate ER
100mg tabletOrphenadrine Citrate ER
100mg tablet extended release 12 hour
How to take Orphenadrine ER
Follow all the prescriber’s instructions. Do not use more than directed.
Take two doses daily, once in the morning and once at night.
The tablets can be taken with or without food.
Swallow the extended-release tablet whole. Do not crush, break, or chew it.
Store orphenadrine extended-release tablets in a closed container at room temperature.
What to do if you miss a dose of Orphenadrine ER
Take a dose as soon as you remember.
If it is almost time for your next dose, wait until then and take a regular dose.
Do not take extra medicine to make up for a missed dose.
Orphenadrine ER contraindications
This medicine is not safe for everyone.
Do not take orphenadrine if you have had an allergic reaction to orphenadrine or have:
Glaucoma
Enlarged prostate
Bladder blockage
Stomach ulcer
Upper intestinal blockage
Cardio-spasm (inability of the esophagus to pass food to the stomach)
Orphenadrine ER warnings
Tell any doctor or other healthcare provider who treats you that you are using this medicine.
The prescriber will need regular visits to monitor the effects of this medicine. Long-term treatment will require regular blood tests. Keep all appointments.
Before starting orphenadrine, tell the prescriber if you are pregnant, breastfeeding, or if you have heart problems.
This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
Orphenadrine can lead to drug abuse. Do not exceed the prescribed dose or use orphenadrine for any other purpose than muscle pain.
Orphenadrine ER interactions
Before starting orphenadrine, tell the prescriber about all the prescription drugs, over-the-counter medications, and supplements you take, particularly:
Other muscle relaxants
Other anticholinergic drugs
The pain reliever propoxyphene
Tell the prescriber if you regularly use drugs that make you sleepy, such as opioid pain relievers, benzodiazepines, or sleeping pills.
Avoid alcohol and cannabis products when taking orphenadrine.
Tell other healthcare providers you are using this medicine before they prescribe new medications.
Orphenadrine ER side effects
Serious side effects
Talk to a healthcare provider if you notice any signs or symptoms of a possible serious side effect, including:
Weakness, tremors, or shaking.
Palpitations, racing heartbeats
Vision changes, eye pain, sensitivity to light
Trouble urinating, decreased urination
Tremor
Confusion, euphoria, agitation, hallucinations (seeing things that are not there).
Allergic reaction: Hives, itching, low blood pressure, swelling, faintness, dizziness
Less serious side effects
Dry mouth.
Dilated pupils
Nausea
Vomiting
Headache
Blurred vision
Constipation
Stomach irritation
Sources:
Norflex drug summary, Prescriber’s Digital Reference (PDR)
Orphenadrine, Memorial Sloan Kettering Cancer Center
Orphenadrine citrate extended-release tablet prescribing information, DailyMed (NIH National Library of Medicine)
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