What is Oxymorphone ER: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Oxymorphone ER overview

BRAND NAMES:

  • oxyMORphone HCl, Opana, Opana ER

Generic Names:

  • Oxymorphone Hcl Er

Uses:

  • Treats moderate to severe pain. This medicine is a narcotic pain reliever.

Therapeutic Classes:

  • Analgesic

Forms:

  • Tablet, Long Acting Tablet

How it’s taken:

  • By mouth

What is Oxymorphone ER used for?

What form(s) does Oxymorphone ER come in

  • Tablet

  • Long Acting Tablet

What are common Oxymorphone ER doses?

  • Tablet 5mg

  • Tablet 7.5mg

  • Tablet 10mg

  • Tablet 15mg

  • Tablet 20mg

  • Tablet 30mg

  • Tablet 40mg

Common Oxymorphone ER prescriptions

  • oxyMORphone HCl ER
    10mg tablet

  • oxyMORphone HCl ER
    15mg tablet

  • oxyMORphone HCl ER
    20mg tablet

  • oxyMORphone HCl ER
    30mg tablet

  • oxyMORphone HCl ER
    40mg tablet

  • oxyMORphone HCl ER
    5mg tablet

  • oxyMORphone HCl ER
    7.5mg tablet

  • oxyMORphone HCl ER
    10mg tablet extended release 12 hour

  • oxyMORphone HCl ER
    15mg tablet extended release 12 hour

  • oxyMORphone HCl ER
    20mg tablet extended release 12 hour

  • oxyMORphone HCl ER
    30mg tablet extended release 12 hour

  • oxyMORphone HCl ER
    40mg tablet extended release 12 hour

  • oxyMORphone HCl ER
    5mg tablet extended release 12 hour

  • oxyMORphone HCl ER
    7.5mg tablet extended release 12 hour

How to take Oxymorphone ER

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

What to do if you miss a dose of Oxymorphone ER

Oxymorphone ER contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to oxymorphone, or if you have severe breathing problems or stomach or bowel blockage (including paralytic ileus).

Oxymorphone ER warnings

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung or breathing problems (such as COPD, sleep apnea), low blood pressure, Addison disease, an enlarged prostate, gallbladder problems, pancreas problems, trouble urinating, or stomach or digestion problems. Also tell your doctor if you have a history of depression, severe scoliosis, head injury, brain tumor, seizures, or drug or alcohol abuse.

  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome (when used with certain medicines)

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may make you dizzy, drowsy, or faint. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Oxymorphone ER interactions

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine may make you dizzy, drowsy, or faint. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • Do not drink alcohol while you are using this medicine.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer.

  • Some medicines can affect how oxymorphone works. Tell your doctor if you are also using any of the following: Cimetidine, cyclobenzaprine, metaxalone, mirtazapine, tramadol, trazodoneDiuretic (water pill)MAO inhibitor (MAOI) within the past 14 daysMedicine to treat depression, anxiety, or mental health problemsPhenothiazine medicineTriptan medicine to treat migraine headaches

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Oxymorphone ER side effects

Serious Side Effects

  • Severe confusion, lightheadedness, dizziness, fainting

  • Severe constipation, stomach pain

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Blue lips, fingernails, or skin

  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures

  • Trouble breathing or slow breathing

Less Serious Side Effects

  • Mild sleepiness or tiredness

  • Mild constipation, nausea, or vomiting

  • Mild sleepiness, drowsiness, or tiredness

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