What is Pre-Pen: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Pre-Pen overview

BRAND NAMES:

  • Pre-Pen

Generic Names:

  • Pre-Pen

Uses:

  • Used to test for penicillin allergy.

Therapeutic Classes:

  • Diagnostic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Pre-Pen used for?

Pre-Pen is used to determine a patient’s sensitivity to penicillin. Pre-Pen can be combined with other medications or used alone to treat or test other allergic reactions.

What form(s) does Pre-Pen come in

  • Injectable

What are common Pre-Pen doses?

  • Ampule 5ML of 0.25ML

How to take Pre-Pen

  • A nurse or other trained health professional will give you this medicine.

  • The nurse will make a small scratch on your arm and apply the medicine. If there is no reaction after 15 minutes, you will receive an injection under your skin. A reaction is any itching, redness, or swelling where the medicine was applied.

  • For the intradermal injection (under your skin), a small amount of medicine is injected into the skin on your forearm. A small bump should appear on your skin. If there is an allergy, you should see a reaction within 5 to 15 minutes.

  • A nurse or other trained health professional will give you this medicine.

  • For the intradermal injection (under your skin), a small amount of medicine is injected into the skin on your forearm. A small bump should appear on your skin. If there is an allergy, you should see a reaction within 5 to 15 minutes.

  • The nurse will make a small scratch on your arm and apply the medicine. If there is no reaction after 15 minutes, you will receive an injection under your skin. A reaction is any itching, redness, or swelling where the medicine was applied.

What to do if you miss a dose of Pre-Pen

Pre-Pen contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to a penicillin skin test.

Pre-Pen warnings

  • Tell your doctor if you are pregnant or breastfeeding.

Pre-Pen interactions

  • Tell your doctor if you are using medicine for allergies, such as diphenhydramine. Also tell your doctor if you are using an antiinflammatory medicine, such as aspirin, ibuprofen, or naproxen.

Pre-Pen side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Skin pain, redness, or itching at the site of the test

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