Pre-Pen Coupons & Prices

Pre-Pen is a brand-name drug that tests for penicillin allergy before administering a dose of penicillin. The active ingredient in Pre-Pen, benzylpenicilloyl polylysine, is injected on the skin and will elicit an allergic reaction on the skin if the patient is allergic to penicillin. Pre-Pen is injected by a healthcare provider and is not sold to patients in commercial pharmacies. On average, the retail price of Pre-Pen is $205.73. Ask the clinic or hospital where you receive Pre-Pen injections if they will accept a SingleCare Pre-Pen coupon; you could pay only $175.69.

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Pre-Pen coupon at Kroger Pharmacy
$178.69
$ 175.69
$3 off with signupwith signup

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Pre-Pen coupon at Harris Teeter Pharmacy
$178.69
$ 175.69
$3 off with signupwith signup

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Pre-Pen coupon at Walmart Neighborhood Market Pharmacy
$191.99
$ 188.99
$3 off with signupwith signup
Pre-Pen coupon at Walmart Pharmacy
$191.99
$ 188.99
$3 off with signupwith signup
Pre-Pen coupon at Costco Pharmacy
$192.55
$ 189.55
$3 off with signupwith signup
Pre-Pen coupon at Publix Pharmacy
$193.41
$ 190.41
$3 off with signupwith signup
$194.83
$ 191.83
$3 off with signupwith signup
$203.96
$ 200.96
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Pre-Pen

Pre-Pen is a brand-name drug that tests for penicillin allergy before administering a dose of penicillin. The active ingredient in Pre-Pen, benzylpenicilloyl polylysine, is injected on the skin and will elicit an allergic reaction on the skin if the patient is allergic to penicillin. Pre-Pen is injected by a healthcare provider and is not sold to patients in commercial pharmacies. On average, the retail price of Pre-Pen is $205.73. Ask the clinic or hospital where you receive Pre-Pen injections if they will accept a SingleCare Pre-Pen coupon; you could pay only $175.69.

About Pre-Pen

Pre-Pen is a brand-name drug that tests for penicillin allergy before administering a dose of penicillin. The active ingredient in Pre-Pen, benzylpenicilloyl polylysine, is injected on the skin and will elicit an allergic reaction on the skin if the patient is allergic to penicillin. Pre-Pen is injected by a healthcare provider and is not sold to patients in commercial pharmacies. On average, the retail price of Pre-Pen is $205.73. Ask the clinic or hospital where you receive Pre-Pen injections if they will accept a SingleCare Pre-Pen coupon; you could pay only $175.69.

Pre-Pen FAQs

How much does Pre-Pen cost without insurance?

Pre-Pen costs around $205.73 for uninsured customers, but dosages may vary. With a SingleCare Pre-Pen coupon, you will pay only $175.69 for the same prescription of Pre-Pen if the hospital or clinic where you receive Pre-Pen injections will accept SingleCare.

How much does Pre-Pen cost with insurance?

Your copay for Pre-Pen with insurance will vary depending on your plan and the dosage required. However, Pre-Pen may be covered by your health insurance as a medical benefit rather than a prescription drug benefit. Ask the clinic or hospital where you receive Pre-Pen injections if they will accept a SingleCare Pre-Pen coupon; you could pay only $175.69.

Does Medicare cover Pre-Pen and how much does it cost?

Pre-Pen is usually not covered under Medicare prescription drug plans, but is covered under Medicare Part B as a medical benefit. Ask the clinic or hospital where you receive Pre-Pen injections if they will accept a SingleCare Pre-Pen coupon; you could pay only $175.69.

What is Pre-Pen?

Pre-Pen is a brand-name drug skin injection used to test for penicillin allergy. A healthcare provider will perform a puncture or an intradermal test.

In a puncture test, the healthcare provider will apply a drop of Pre-Pen on the skin on the forearm. With a needle, the healthcare provider will create a very small puncture in the skin right below the drop.

For an intradermal test, the healthcare provider will inject Pre-Pen immediately below the skin surface on the upper arm and then inject saline solution.

For either method, signs of an allergic reaction, such as redness, swelling, or itching, will appear in five to 15 minutes.

What are the side effects of Pre-Pen?

The most common side effect of Pre-Pen is an allergic reaction at the test site: swelling, redness, and itching. More serious allergic reactions, such as trouble breathing, low blood pressure, and anaphylaxis, are very rare. The patient will be observed before and during the test. If there is a positive test, a tourniquet may be applied and epinephrine administered.

Where are Pre-Pen coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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