What is Protriptyline: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Protriptyline overview

BRAND NAMES:

Generic Names:

  • Protriptyline Hcl

Uses:

  • Treats depression. This medicine is a TCA.

Therapeutic Classes:

  • Antidepressant

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Protriptyline used for?

What form(s) does Protriptyline come in

  • Tablet

What are common Protriptyline doses?

  • Tablet 5MG

  • Tablet 10MG

Common Protriptyline prescriptions

  • Protriptyline HCl
    10mg tablet

  • Protriptyline HCl
    5mg tablet

How to take Protriptyline

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. You may need to take this medicine for a few weeks before you begin to feel better.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. You may need to take this medicine for a few weeks before you begin to feel better.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Protriptyline

Protriptyline contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to protriptyline, or you had a recent heart attack.

Protriptyline warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart or blood vessel disease, glaucoma, problems with urination, seizures, or thyroid disease.

  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • This medicine may raise or lower your blood sugar level.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Protriptyline interactions

  • Do not use this medicine together with cisapride. Do not use this medicine and an MAO inhibitor (MAOI) within 14 days of each other.

  • Some foods and medicines can affect protriptyline works. Tell your doctor if you are also using any of the following:Cimetidine, guanethidine, quinidine, tramadolThyroid medicine, a phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine), medicine for heart rhythm problems (propafenone, flecainide)

  • Tell your doctor if you are also using other medicine to treat depression, such as fluoxetine, paroxetine, or sertraline. You may need to wait at least 5 weeks before you begin using protriptyline.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • This medicine may raise or lower your blood sugar level.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Protriptyline side effects

Serious Side Effects

  • Feeling anxious, agitated, confused, restless, or irritable

  • Change in how much or how often you urinate, problems urinating

  • Chest pain or fast, pounding, or uneven heartbeat

  • Lightheadedness, dizziness, or fainting

  • Thoughts of hurting yourself or others, unusual behavior

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Eye pain, vision changes, seeing halos around lights

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