Pylera is a Ulcer Anti-Infective w/ Bismuth Combinations class medication produced by H2 Pharma. It is used (usually in combination with omeprazole) to treat peptic ulcers caused by Helicobacter pylori bacteria. Each Pylera capsule contains three ingredients: bismuth subcitrate potassium (140 mg), metronidazole (125 mg), and tetracycline (125 mg). The average retail price of Pylera is $397.55 per 1, 120 capsules box, but you can pay just $193.44 for 120, 140-125-125mg capsules of Pylera with a SingleCare prescription drug discount card. Pylera is a brand-name drug.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/20/2025
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Pylera is a Ulcer Anti-Infective w/ Bismuth Combinations class medication produced by H2 Pharma. It is used (usually in combination with omeprazole) to treat peptic ulcers caused by Helicobacter pylori bacteria. Each Pylera capsule contains three ingredients: bismuth subcitrate potassium (140 mg), metronidazole (125 mg), and tetracycline (125 mg). The average retail price of Pylera is $397.55 per 1, 120 capsules box, but you can pay just $193.44 for 120, 140-125-125mg capsules of Pylera with a SingleCare prescription drug discount card. Pylera is a brand-name drug.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Pylera Retail Price | Bismuth/Metronidaz/Tetracyclin Retail Price | Bismuth/Metronidaz/Tetracyclin SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $362.40 | $855.60 | $226.80 |
| Walmart | $364.80 | - | - |
| Walgreens | $364.80 | $642.00 | $331.20 |
| Kroger Pharmacy | $364.80 | $994.80 | $750.00 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Pylera is a Ulcer Anti-Infective w/ Bismuth Combinations class medication produced by H2 Pharma. It is used (usually in combination with omeprazole) to treat peptic ulcers caused by Helicobacter pylori bacteria. Each Pylera capsule contains three ingredients: bismuth subcitrate potassium (140 mg), metronidazole (125 mg), and tetracycline (125 mg). The average retail price of Pylera is $397.55 per 1, 120 capsules box, but you can pay just $193.44 for 120, 140-125-125mg capsules of Pylera with a SingleCare prescription drug discount card. Pylera is a brand-name drug.
The standard out-of-pocket cost of Pylera without health insurance is $397.55 per 1, 120 capsules box though you can save using a SingleCare Pylera coupon to pay only $193.44 for 120, 140-125-125mg capsules of Pylera. If you don’t have access to an insurance plan, you can still use SingleCare for free Pylera savings.
Each insurance formulary is different and may or may not cover Pylera. The cost of Pylera with insurance coverage varies depending on your plan - check with your insurance provider for specific drug coverage and copay details. If your insurance does not cover Pylera, you can use SingleCare to get discounts on Pylera at your participating pharmacy. You can also use SingleCare coupons if you have Medicare or Medicaid. If Medicare or Medicaid don’t cover your Pylera prescription, you can use SingleCare instead. Go to the SingleCare website or app to compare the lowest price of Pylera with SingleCare versus your copay with insurance or Medicare.
In addition to Pylera coupons, there may be Pylera coupons and patient assistance programs available from H2 Pharma or other organizations. However, these programs may have eligibility requirements. Instead, you can use a SingleCare Pylera savings card to get a great price of $193.44 per 120, 140-125-125mg capsules of Pylera. If you have a valid prescription, anyone in the United States or Puerto Rico can use free Pylera coupons from SingleCare.
Pylera costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Pylera and how much the copay or coinsurance is. If Pylera is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full price of $397.55 for 1, 120 capsules box. In that case, using a SingleCare coupon for Pylera could save you more money than Medicare. Our lowest price for Pylera is currently $193.44 for 120, 140-125-125mg capsules.
Pylera is a brand name drug made by H2 Pharma. The generic version of Pylera is Bismuth Subcitrate Potassium-Metronidazole-Tetracycline and is less costly than the price of Pylera, which is $397.55 per 1, 120 capsules box, but uses the same active ingredients as Pylera. Use a SingleCare prescription drug discount card to pay $193.44 for 120, 140-125-125mg capsules.
Pylera is a prescription medicine used (generally in combination with the drug omeprazole) to treat peptic ulcer caused by Helicobacter pylori infection. It is a combination medicine. Each Pylera capsule contains three ingredients: bismuth subcitrate potassium, metronidazole, and tetracycline.
Take your medicine with a full glass of water. Swallow the Pylera capsule whole. Do not chew or crush. Do not take Pylera with milk or antacids.
Take this medicine for the full length of treatment, even if you start to feel better. If you skip doses, your infection could become resistant to medication.
Store Pylera at room temperature. Keep away from direct light, heat, and moisture. Keep each capsule in the blister pack until you are ready to take it.
If you miss a dose of Pylera, take it as soon as you can. However, if it’s almost time for the next dose, skip the missed dose. Do not take two doses at once. If you miss more than 4 doses, consult your health care provider for guidance.
Common side effects of Pylera may include discolored feces, nausea, diarrhea, stomach pain, headache, indigestion, altered taste, weakness, dizziness, black tongue, and tooth discoloration, among others. Tell your doctor if you have diarrhea that is watery or bloody. Pylera can also cause sun sensitivity, so avoid sunlight and tanning beds, and wear protective clothing and sunscreen while outdoors.
Serious side effects can occur, too. If you have any symptoms that indicate a skin or allergic reaction, you should get emergency medical help. These symptoms may include hives, difficulty breathing, swelling, fever, sore throat, burning eyes, skin pain, red or purple rash, blistering, or peeling skin.
This is not a full list of side effects, and others may occur. Consult your healthcare professional for more information and a full list of adverse effects that may occur with Pylera.
Pylera is not safe for everyone. Before taking Pylera, tell your healthcare provider about any medical conditions you have. You should not take Pylera if you are allergic to any of the ingredients in this medication or similar drugs. Others who should not take Pylera include:
Anyone under eight years old
People who use alcohol
People who have taken disulfiram within 14 days
People with severe kidney or liver problems
Individuals who are pregnant
People with Cockayne syndrome
Many other medical conditions would require the prescriber and patient to weigh risks and benefits, such as older adults or people with heart problems. Consult your healthcare provider for professional medical advice.
Metronidazole, an ingredient in Pylera, has caused cancer in animal studies. It is not known if this applies to humans.
Before taking Pylera, tell your healthcare provider about all the medications you take, including prescription and over-the-counter (OTC) medicines, vitamins, and supplements.
Some substance and drug interactions include:
Alcohol: Avoid alcohol while taking Pylera and for at least three days after your last dose of Pylera. Combining alcohol with Pylera can cause you to become very sick with stomach cramps, nausea, vomiting, headaches, and flushing. Also, check alcohol content in products such as sauces, cough syrups, and mouthwashes. Do not use any products that contain alcohol or propylene glycol while you take Pylera.
Disulfiram
Oral birth control pills (ask your healthcare provider about a different form of birth control such as condoms or a vaginal ring)
Blood thinners
Lithium
Antacids
Other drug interactions may occur. Talk to your healthcare provider about drug interactions and how they might affect you.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved