What is Repaglinide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Repaglinide overview

BRAND NAMES:

  • Prandin

Generic Names:

  • Repaglinide

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Repaglinide used for?

Prandin is a prescription-only medication that is used to control high blood sugar levels in patients diagnosed with type 2 diabetes. Prandin works by increasing insulin which is taken from the pancreas to regulate the movement of sugar into your cells.

What form(s) does Repaglinide come in

  • Tablet

What are common Repaglinide doses?

  • Tablet 0.5MG

  • Tablet 1MG

  • Tablet 2MG

Common Repaglinide prescriptions

  • Repaglinide
    0.5mg tablet

  • Repaglinide
    1mg tablet

  • Repaglinide
    2mg tablet

How to take Repaglinide

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take this medicine before each meal, up to 4 times per day. You make take it up to 30 minutes before the meal.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Do not take this medicine if you skip a meal.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Do not take this medicine if you skip a meal.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take this medicine before each meal, up to 4 times per day. You make take it up to 30 minutes before the meal.

What to do if you miss a dose of Repaglinide

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Do not take this medicine if you skip a meal.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Repaglinide contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to repaglinide.

Repaglinide warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or heart problems.

  • This medicine may cause low blood sugar levels.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Repaglinide interactions

  • Do not take gemfibrozil while you are using this medicine.

  • Some medicines can affect how repaglinide works. Tell your doctor if you are using any of the following:Albuterol, carbamazepine, clarithromycin, clonidine, clopidogrel, clozapine, cyclosporine, danazol, deferasirox, disopyramide, erythromycin, fluoxetine, guanethidine, isoniazid, itraconazole, ketoconazole, montelukast, niacin, octreotide, olanzapine, pentoxifylline, phenobarbital, pramlintide, reserpine, rifampin, somatropin, terbutaline, or trimethoprimBirth control pillBlood pressure medicineDiuretic (water pill)Insulin or other diabetes medicineMAO inhibitorMedicine to treat HIV infectionNSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Phenothiazine medicineSteroid medicineSulfa drugThyroid medicine

  • Tell your doctor if you are using medicine to treat an infection, such as chloramphenicol, clarithromycin, erythromycin (Ery-Tab®), trimethoprim (Trimpex®), itraconazole (Sporanox®), ketoconazole (Nizoral®), miconazole (Monistat®), or isoniazid (Nydrazid®).

  • Tell your doctor if you are also using NSAID pain or arthritis medicine (such as aspirin, celecoxib, ibuprofen, naproxen, Aleve®, Celebrex®, or Motrin®), an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®), a sulfa drug (such as sulfamethoxazole, sulfasalazine, Bactrim®, or Septra®), or a blood thinner (such as warfarin, Coumadin®). Make sure your doctor knows if you are also using a steroid medicine (such as dexamethasone, prednisolone, prednisone, or Medrol®), a phenothiazine medicine (such as prochlorperazine, Compazine®, Phenergan®, Thorazine®, or Trilafon®), thyroid medicine, or birth control pills.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will also need to check your blood sugar regularly at home.

Repaglinide side effects

Serious Side Effects

  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness or lightheadedness, hunger, confusion

  • Seizures

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

Less Serious Side Effects

  • Weight gain

  • Cough, runny or stuffy nose, sore throat

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