Rifaximin Coupons & Prices

Rifaximin is a prescription drug approved by the FDA for the treatment of traveler's diarrhea. This medication can also be used to treat irritable bowel syndrome (IBS) and hepatic encephalopathy. There is no generic version of Rifaximin available on the market. Your Rifaximin prescription can be quite expensive with an average retail price of $491.76. Use a SingleCare Rifaximin coupon at any local CVS, Target, Longs Drugs, Walmart, Kroger, Fry's, Harris Teeter, Walgreens or Duane Reade to save significantly. Dosage can affect Rifaximin prices. SingleCare’s lowest price for Rifaximin is currently $451.88 for 0.12, 500gm of bottle.

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Rifaximin coupon at Kroger Pharmacy
$454.88
$ 451.88
$3 off with signupwith signup

Show this free card to your pharmacist.

This coupon is not insurance.
Rifaximin coupon at Harris Teeter Pharmacy
$454.88
$ 451.88
$3 off with signupwith signup
Rifaximin coupon at CVS Pharmacy
$464.14
$ 461.14
$3 off with signupwith signup
Rifaximin coupon at Publix Pharmacy
$482.72
$ 479.72
$3 off with signupwith signup
Rifaximin coupon at Walgreens Pharmacy
$484.23
$ 481.23
$3 off with signupwith signup
Rifaximin coupon at Walmart Neighborhood Market Pharmacy
$488.51
$ 485.51
$3 off with signupwith signup
$488.51
$ 485.51
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 09/23/2026

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About Rifaximin

Rifaximin is a prescription drug approved by the FDA for the treatment of traveler's diarrhea. This medication can also be used to treat irritable bowel syndrome (IBS) and hepatic encephalopathy. There is no generic version of Rifaximin available on the market. Your Rifaximin prescription can be quite expensive with an average retail price of $491.76. Use a SingleCare Rifaximin coupon at any local CVS, Target, Longs Drugs, Walmart, Kroger, Fry's, Harris Teeter, Walgreens or Duane Reade to save significantly. Dosage can affect Rifaximin prices. SingleCare’s lowest price for Rifaximin is currently $451.88 for 0.12, 500gm of bottle.

About Rifaximin

Rifaximin is a prescription drug approved by the FDA for the treatment of traveler's diarrhea. This medication can also be used to treat irritable bowel syndrome (IBS) and hepatic encephalopathy. There is no generic version of Rifaximin available on the market. Your Rifaximin prescription can be quite expensive with an average retail price of $491.76. Use a SingleCare Rifaximin coupon at any local CVS, Target, Longs Drugs, Walmart, Kroger, Fry's, Harris Teeter, Walgreens or Duane Reade to save significantly. Dosage can affect Rifaximin prices. SingleCare’s lowest price for Rifaximin is currently $451.88 for 0.12, 500gm of bottle.

Rifaximin FAQs

How much does Rifaximin cost without insurance?

Rifaximin is quite expensive without insurance coverage, costing around $491.76. Customers who use a SingleCare Rifaximin coupon can pay as low as $451.88 for their prescription. Use your free SingleCare coupon for your prescription at pharmacies near you such as Target, Kroger, and Fry's.

How much does Rifaximin cost with insurance?

The average copay for Rifaximin can vary depending on your type of health insurance plan and level of coverage. However, using a SingleCare discount card could save you significantly on your next prescription. Pay as low as $451.88 at pharmacies near you such as Walmart, Walgreens, and Longs Drugs.

Does Medicare cover Rifaximin and how much does it cost?

Rifaximin is often covered by your Medicare Part D and Medicare Advantage plans. The average Medicare copay can still be expensive with a range of about $95-$2724. However, using a SingleCare savings card could save you more than Medicare insurance. Ask your pharmacist at your local pharmacy to compare prices at checkout so that you can get the lowest price possible.

What is the brand name of Rifaximin?

Xifaxan is the brand name of Rifaximin.

What is Rifaximin?

Rifaximin (Xifaxan) is a generic prescription drug approved by the FDA in the treatment of diarrhea. This tablet can also be used to treat irritable bowel syndrome and hepatic encephalopathy. Hepatic encephalopathy is a brain disorder caused by a buildup of toxins in the brain due to liver disease. Rifaximin is an antibiotic that works against bacteria such as E. coli that cause diarrhea. This medication is meant for persons older than 12.

Always remember to read the instruction leaflet and to consult your healthcare provider about medical advice concerning the correct dosage and frequency for your medical condition. Rifaximin is meant to be taken 3 times a day for the treatment of diarrhea and irritable bowel syndrome. It is meant to be taken 2 times a day for the treatment of hepatic encephalopathy. The greatest effect is achieved when taken evenly apart. Rifaximin should not be shared even with persons experiencing the same conditions. Skipping doses and changing length or frequency of treatment can increase the risk of infection by a resistant bacterial strain.

What are the side effects of Rifaximin?

It is important to remember to consult your doctor on what medications and foods should be taken when using Rifaximin in order to avoid side effects. The most common side effects include flatulence, headache, and nausea. Consult your doctor for medical advice on how to treat side effects, especially if they persist or get worse.

Severe allergic reactions to Rifaximin are not common. However, immediately contact your healthcare professional should you experience stomach cramps, blood, or mucus in your stool or fainting. This is not a full list of possible side effects. Seek medical advice before using Rifaximin to determine if this drug is right for you.

Where are Rifaximin coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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